Detail Information

Basic Information:


  VIRBase ID:  

HHID00019487

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-34b-3p:           IFNB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-34b-3p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0004676 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-34b-3p
rs1196309691 chr11:111513001    A/G
rs1259490946 chr11:111513005    C/T
rs1316950494 chr11:111512995    A/G
rs1264066527 chr11:111512989    A/G
rs376886963 chr11:111512988    A/C
rs376886963 chr11:111512988    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-34b-3p
Exosome Serum     18589210
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-34b-3p
Formaldehyde 712 Drug interaction    RC00007046
Topotecan 60700 Drug interaction    RC00007053
Epinephrine 5816 Drug interaction    RC00007050
Estradiol 5757 Drug interaction    RC00007049
Eloxatine 5310940 Drug interaction    RC00007056
Sirolimus 5284616 Drug interaction    RC00007055
Ribavirin 37542 Drug interaction    RC00007052
Doxorubicin 31703 Drug interaction    RC00007051
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00007048
Verapamil 2520 Drug interaction    RC00007047
Docetaxel 148124 Drug interaction    RC00007054
Estrogen - Drug interaction    RC00007061
Anthranilamide-pyrazolo[1,5-a]pyrimidine - Drug interaction    RC00007060
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00007059
platinum-based doublet chemotherapy - Drug interaction    RC00007058
Peginterferon alfa-2b - Drug interaction    RC00007057
Chemotherapy - Drug interaction    RC00008883
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-34b-3p
Cisplatin 5702198       30778022
(7S,9S)-7-[(2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydron;chloride 53630345       30778022
Paclitaxel 36314       30778022
Doxorubicin 31703       30778022
(9S)-7-[(2R)-4-Amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione 137704806       30778022

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-34b-3p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence RT-PCR
Weak-Evidence Microarray
Support Database VIRmiRNA

References:


PMID 20969775 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Con1 cells Interactor2 expression None
Description The result was that the expression level of 3 miRNAs (miR-27b, miR-378, miR-422b) in SVR was significantly higher than that in NR, whereas the expression level of 5 miRNAs (miR-34b, miR-145, miR-143, miR-652, and miR-18a) in SVR was significantly lower than that in NR.

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