Detail Information

Basic Information:


  VIRBase ID:  

HHID00019482

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-378a-5p:           IFNB1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-378a-5p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0000731 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-378a-5p
rs1195025900 chr5:149732846    T/A
rs1329713344 chr5:149732828    GC/G
rs1361372361 chr5:149732844    C/T
rs1457638573 chr5:149732841    GGTCCTGT/G
rs781166851 chr5:149732847    G/T
rs951679960 chr5:149732840    A/T
rs1375418377 chr5:149732827    GGCTCCTGACTCCAGGT/G
rs1387429942 chr5:149732833    T/A
rs376185067 chr5:149732836    C/G
rs979812780 chr5:149732831    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-378a-5p
Exosome Plasma     29323722
Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Serum     24797360
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-378a-5p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence RT-PCR
Weak-Evidence Microarray
Support Database VIRmiRNA

References:


PMID 20969775 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Con1 cells Interactor2 expression None
Description The result was that the expression level of 3 miRNAs (miR-27b, miR-378, miR-422b) in SVR was significantly higher than that in NR, whereas the expression level of 5 miRNAs (miR-34b, miR-145, miR-143, miR-652, and miR-18a) in SVR was significantly lower than that in NR.

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