Detail Information

Basic Information:


  VIRBase ID:  

HHID00019481

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-370-3p:           IFNB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-370-3p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0000722 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-370-3p
rs1351716221 chr14:100911196    G/T
rs200587431 chr14:100911201    A/G
rs200587431 chr14:100911201    A/T
rs745369283 chr14:100911206    G/A
rs757753232 chr14:100911199    G/T
rs775455617 chr14:100911205    GGTCT/G
rs978822198 chr14:100911203    C/G
rs978822198 chr14:100911203    C/T
rs1215671560 chr14:100911189    T/C
rs751960148 chr14:100911188    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-370-3p
Cytoplasm Cervical cancer cell lines (HeLa|SiHa)     31703640
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Follicular fluid     23666971
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-370-3p
8-Aminoadenosine 96851 Drug resistant
Actinomycin X4357G methoxime 9573583 Drug sensitive
Tetraethyleniminobenzo-quinone 95735 Drug resistant
Redoxal 72571 Drug sensitive
Verrucarin A 6326658 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
2,3-Diphenyl-1,4-naphthoquinone 555037 Drug sensitive
2-Azaadenine 5480214 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Tetrocarcin A, sodium salt 54724658 Drug sensitive
Austocystin D 5470400 Drug resistant
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Simvastatin 54454 Drug resistant
Indanthren Corinth RK 5351878 Drug sensitive
Centaureidin 5315773 Drug sensitive
Chartreusin 5281394 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Isobrucein A 441802 Drug sensitive
Glaucarubinone 441796 Drug sensitive
Antibiotic X-14766A 434840 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
Lapachol 3884 Drug sensitive
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
N-(2-Bromo-5-methoxybenzylidene)-6,7-dimethoxy-1-naphthalenamine 387181 Drug sensitive
3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Jasplakinolide epoxide C 372550 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
Antimycin A3 245869 Drug sensitive
Sarcoviolin 24202820 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Kinetin riboside 20345 Drug resistant
Actinomycin VII 20055431 Drug sensitive
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
Erlotinib 176870 Drug resistant
(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(3S)-5-[(2S,3S,5R,6R)-6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid 152743331 Drug sensitive
1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug sensitive
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
Tannic acid, 95% 134129492 Drug resistant
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
Unii-C616DV5Y11 117587576 Drug sensitive
Unii-9JU14BJ5QG 109374088 Drug sensitive
Perillyl alcohol 10819 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
(Z)-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)-5-methoxyindolin-2-one - Drug sensitive
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
cis-difluorobis(1-phenylhexane-1,3-dionato)titanium(iv) - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug sensitive
roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
5-methoxy camptothecin - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
antineoplastic-615538 - Drug sensitive
arylmethylene-f - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
phosphocitrate penta sodium salt - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-370-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00004131
Gemcitabine 60750 Drug interaction    RC00004130
Progesterone 5994 Drug interaction    RC00004127
Sunitinib 5329102 Drug interaction    RC00004135
Diethylstilbestrol 448537 Drug interaction    RC00004134
5-Fluorouracil 3385 Drug interaction    RC00004126
Doxorubicin 31703 Drug interaction    RC00004129
Omacetaxine mepesuccinate 285033 Drug interaction    RC00004133
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00004125
Verapamil 2520 Drug interaction    RC00004124
Acetaminophen 1983 Drug interaction    RC00004123
Ginsenoside Rh2 119307 Drug interaction    RC00004132
Hesperidin 10621 Drug interaction    RC00004128
Chemotherapy - Drug interaction    RC00008856
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-370-3p
Temozolomide 5394       27595933
Doxorubicin 31703       29242506
Rituximab -       29242506

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-370-3p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence RT-PCR
Weak-Evidence Microarray
Support Database VIRmiRNA

References:


PMID 20969775 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Con1 cells Interactor2 expression None
Description The result was that the expression level of 3 miRNAs (miR-27b, miR-378, miR-422b) in SVR was significantly higher than that in NR, whereas the expression level of 5 miRNAs (miR-34b, miR-145, miR-143, miR-652, and miR-18a) in SVR was significantly lower than that in NR.

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