Basic Information:

  VIRBase ID:  

HHID00019480

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-126-3p:  MIMAT0000445          IFNB1:  NM_002176     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-126-3p	IFNB1
miRBase Accession/Entrez ID	MIMAT0000445	3456
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-126-3p	rs1037814508 chr9:136670673    C/T rs1298052992 chr9:136670670    A/C rs556742905 chr9:136670667    A/G rs760999709 chr9:136670674    G/A rs760999709 chr9:136670674    G/T rs955612972 chr9:136670671    T/C rs1028572211 chr9:136670660    G/A rs1554752671 chr9:136670659    C/A rs759310336 chr9:136670659    CGTGA/C rs772277946 chr9:136670654    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNB1	chr9:21077198-21077199(-) m6A 3'UTR       27773535 chr9:21077273-21077274(-) m6A 3'UTR       27773535 chr9:21077278-21077279(-) m6A 3'UTR       27773535 chr9:21077308-21077309(-) m6A CDS       27773535 chr9:21077328-21077329(-) m6A CDS       27773535 chr9:21077347-21077348(-) m6A CDS       27773535 chr9:21077375-21077376(-) m6A CDS       27773535 chr9:21077592-21077593(-) m6A CDS       27773535 chr9:21077611-21077612(-) m6A CDS       27773535 chr9:21077695-21077696(-) m6A CDS       27773535 chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-126-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human umbilical vein endothelial cells|Serum     29127370 Exosome B cell line (Raji)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Blood|Endothelial cells|Epithelial cells|Mast cells     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-126-3p	Iodine Green 9956454 Drug sensitive Actinomycin X4357G methoxime 9573583 Drug sensitive 4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Tolonium chloride 7083 Drug sensitive Azure B 68275 Drug sensitive Neocuproine 65237 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive Verrucarin A 6326658 Drug sensitive 3-Deazauridine 54684286 Drug sensitive Cuspidatin C 5459164 Drug sensitive Vorinostat 5311 Drug sensitive Kekule 499328 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Propyl gallate 4947 Drug resistant Ossirene 451379 Drug sensitive Mycophenolic acid 446541 Drug sensitive Isopinnatal 44558939 Drug sensitive 2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive beta-Lapachone 3885 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive 4-Phenacyloxychromen-2-one 386272 Drug resistant 2-Ethylaminoestradiol 384235 Drug sensitive 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Sanguilutine pseudobase 371258 Drug sensitive Rocaglamide 331783 Drug sensitive Phomazarin 318385 Drug resistant 2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive Flurocitabine 3034016 Drug sensitive Phenanthrene-9,10-diimine 2981 Drug sensitive Dichloroallyl lawsone 277767 Drug sensitive (15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive 4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive Hydrazine sulfate 24842 Drug sensitive Antimycin A3 245869 Drug sensitive 4-[[(8-Hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid 219564 Drug sensitive 8-Hydroxyquinoline 1923 Drug sensitive 8-Chloro-cyclicamp 17856967 Drug sensitive Ammonium tetrathiomolybdate 15251598 Drug sensitive Raltitrexed 135400182 Drug sensitive (2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive Gentian violet 11057 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive tp4ek - Drug resistant 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-methyl- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug sensitive 2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive antineoplastic-641296 - Drug sensitive antineoplastic-641297 - Drug sensitive arylmethylene-f - Drug sensitive Tetraplatin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-126-3p	10-Hydroxycamptothecin 97226 Drug interaction    RC00003058 Hyaluronidase 91820602 Drug interaction    RC00003076 Formaldehyde 712 Drug interaction    RC00003041 Oxaliplatine 6857599 Drug interaction    RC00003070 (-)-Epigallocatechin gallate 65064 Drug interaction    RC00003057 Cytarabine 6253 Drug interaction    RC00003050 Capecitabine 60953 Drug interaction    RC00003056 Gemcitabine 60750 Drug interaction    RC00003055 Vincristine 5978 Drug interaction    RC00003049 Estradiol 5757 Drug interaction    RC00003048 Prednisolone 5755 Drug interaction    RC00003047 Alpelisib 56649450 Drug interaction    RC00003075 Bleomycin a2 5360373 Drug interaction    RC00003069 Vorinostat 5311 Drug interaction    RC00003046 Eloxatine 5310940 Drug interaction    RC00003068 Imatinib 5291 Drug interaction    RC00003045 Calcitriol 5280453 Drug interaction    RC00003067 Decitabine 451668 Drug interaction    RC00003065 Diethylstilbestrol 448537 Drug interaction    RC00003064 Ribociclib 44631912 Drug interaction    RC00003074 Trichostatin A 444732 Drug interaction    RC00003063 Cyclopamine 442972 Drug interaction    RC00003062 Paclitaxel 36314 Drug interaction    RC00003054 Enoxacin 3229 Drug interaction    RC00003044 Doxorubicin 31703 Drug interaction    RC00003053 Daunorubicin 30323 Drug interaction    RC00003052 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003043 Tamoxifen 2733526 Drug interaction    RC00003066 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol 25262965 Drug interaction    RC00003073 Capivasertib 25227436 Drug interaction    RC00003072 Sorafenib 216239 Drug interaction    RC00003061 Arsenic trioxide 14888 Drug interaction    RC00003051 Docetaxel 148124 Drug interaction    RC00003060 Gefitinib 123631 Drug interaction    RC00003059 Urea 1176 Drug interaction    RC00003042 Trametinib 11707110 Drug interaction    RC00003071 Asparaginase Escherichia coli - Drug interaction    RC00003077 GSK1070916 - Drug interaction    RC00003078 SCH772984 - Drug interaction    RC00003079 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00003080 Aidi injection - Drug interaction    RC00003081 Glucocorticoid - Drug interaction    RC00003082 Mistletoe lectin-I - Drug interaction    RC00003083

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-126-3p	Temozolomide 5394       30980849 Dabrafenib 44462760       31227006

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-126-3p
Interactor2: IFNB1

Evidence Support:

Strong-Evidence	RT-PCR
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	20969775	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Con1 cells	Interactor2 expression	None
Description	The result was that the expression level of 3 miRNAs (miR-27b, miR-378, miR-422b) in SVR was significantly higher than that in NR, whereas the expression level of 5 miRNAs (miR-34b, miR-145, miR-143, miR-652, and miR-18a) in SVR was significantly lower than that in NR.