Detail Information

Basic Information:


  VIRBase ID:  

HHID00019479

  Virus:  

Hepacivirus C (Hepatitis C virus subtype 1b,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-145-5p:           IFNB1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-145-5p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0000437 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-145-5p
rs1191199140 chr5:149430675    G/A
rs1394460469 chr5:149430676    G/A
rs1402883964 chr5:149430671    C/G
rs934436084 chr5:149430661    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-145-5p
Cytoplasm Human colon cancer cell line (HCT-116)     28964256
Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Serum     25135963
Exosome Cerebrospinal fluid     25420022
Exosome Peripheral blood     32785072
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Nucleus Myoepithelial cells     29073169

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-145-5p
Tetraethyleniminobenzo-quinone 95735 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Fludarabine 657237 Drug resistant
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
[(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant
Sirolimus 5284616 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Aminopyrimidine-F 406276 Drug sensitive
Lapachol 3884 Drug sensitive
Ellipticine 3213 Drug sensitive
Estramustine 259331 Drug sensitive
5-Nitroso-8-hydroxyquinoline 19103 Drug sensitive
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
Formycin b 135449281 Drug resistant
Abiraterone 132971 Drug sensitive
15-Deacetylsergeolide 125729 Drug sensitive
3-(4-(5-Methoxy-1H-benzo[d]imidazol-2-yl)phenyl)-5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole 118624714 Drug sensitive
4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug resistant
viridomycin - Drug resistant
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
naphtho[1,2-b]quinolizinium, 10,13-dimethyl- chloride - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
ambrosin piperidine diadduct di-n-oxide - Drug sensitive
pancratium littorale - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-145-5p
Azacitidine 9444 Drug interaction    RC00002904
Hyaluronidase 91820602 Drug interaction    RC00002927
Rosiglitazone 77999 Drug interaction    RC00002912
Oxaliplatine 6857599 Drug interaction    RC00002924
Irinotecan 60838 Drug interaction    RC00002911
Gemcitabine 60750 Drug interaction    RC00002910
Phenylephrine 6041 Drug interaction    RC00002903
Cholesterol 5997 Drug interaction    RC00002902
Vincristine 5978 Drug interaction    RC00002901
Serine 5951 Drug interaction    RC00002900
Mitomycin 5746 Drug interaction    RC00002899
Temozolomide 5394 Drug interaction    RC00002898
Sunitinib 5329102 Drug interaction    RC00002923
Eloxatine 5310940 Drug interaction    RC00002922
Sodium butyrate 5222465 Drug interaction    RC00002921
2-{[2-Ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 46843772 Drug interaction    RC00002926
Decitabine 451668 Drug interaction    RC00002920
Tretinoin 444795 Drug interaction    RC00002918
Staurosporine 44259 Drug interaction    RC00002909
Vemurafenib 42611257 Drug interaction    RC00002925
Epirubicin 41867 Drug interaction    RC00002908
Ribavirin 37542 Drug interaction    RC00002907
Paclitaxel 36314 Drug interaction    RC00002906
5-Fluorouracil 3385 Drug interaction    RC00002897
Doxorubicin 31703 Drug interaction    RC00002905
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002896
Verapamil 2520 Drug interaction    RC00002895
Lenalidomide 216326 Drug interaction    RC00002917
Docetaxel 148124 Drug interaction    RC00002916
Pemetrexed 135410875 Drug interaction    RC00002919
Gefitinib 123631 Drug interaction    RC00002915
7-Ethyl-10-hydroxycamptothecin 104842 Drug interaction    RC00002914
Fulvestrant 104741 Drug interaction    RC00002913
Peginterferon alfa-2b - Drug interaction    RC00002928
5-aza-2'-deoxycytidine (5-Aza-CdR) + Doxorubicin - Drug interaction    RC00002929
Genistein + 5-AzaC - Drug interaction    RC00002930
Genistein + 5-AzaC + Trichostatin A(TSA) - Drug interaction    RC00002931
Glucocorticoid - Drug interaction    RC00002932
Interleukin 13 (IL-13) - Drug interaction    RC00002933
Olea europaea leaf extract - Drug interaction    RC00002934
Chemotherapy - Drug interaction    RC00008846
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-145-5p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-145-5p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence RT-PCR
Weak-Evidence Microarray
Support Database VIRmiRNA

References:


PMID 20969775 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Con1 cells Interactor2 expression None
Description The result was that the expression level of 3 miRNAs (miR-27b, miR-378, miR-422b) in SVR was significantly higher than that in NR, whereas the expression level of 5 miRNAs (miR-34b, miR-145, miR-143, miR-652, and miR-18a) in SVR was significantly lower than that in NR.

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