Basic Information:

  VIRBase ID:  

HHID00019450

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Mus musculus

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-122-3p:  MIMAT0017005          Hnf4a:  NM_008261     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-122-3p	Hnf4a
miRBase Accession/Entrez ID	MIMAT0017005	15378
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	Hnf//HNF-//HNF-4//Hnf4//Hnf4alpha//MODY//MODY1//Nr//Nr2a1//TCF-14//Tcf14

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Hnf4a	chr2:163552647-163552648(+) m1A CDS//exon       26863196 chr2:163570187-163570188(+) m6A 3'UTR       26404942//22575960 chr2:163570229-163570230(+) m6A 3'UTR       26404942//22575960 chr2:163570301-163570302(+) m6A 3'UTR       25456834//25569111//26404942//22575960 chr2:163570313-163570314(+) m6A 3'UTR       25456834//25569111//26404942//22575960 chr2:163570332-163570333(+) m6A 3'UTR       25456834//25569111//26404942//22575960 chr2:163570430-163570431(+) m6A 3'UTR       25456834//25569111//22575960 chr2:163570507-163570508(+) m6A 3'UTR       25456834//22575960 chr2:163570956-163570957(+) m6A 3'UTR       26404942 chr2:163570972-163570973(+) m6A 3'UTR       26404942 chr2:163570981-163570982(+) m6A 3'UTR       26404942 chr2:163571070-163571071(+) m6A 3'UTR       26404942 chr2:163571085-163571086(+) m6A 3'UTR       26404942 chr2:163571262-163571263(+) m6A 3'UTR       26404942 chr2:163571281-163571282(+) m6A 3'UTR       26404942 chr2:163571299-163571300(+) m6A 3'UTR       26404942 chr2:163571986-163571987(+) m6A 3'UTR       26404942 chr2:163572002-163572003(+) m6A 3'UTR       26404942 chr2:163572011-163572012(+) m6A 3'UTR       26404942 chr2:163572054-163572055(+) m6A 3'UTR       26404942 chr2:163572315-163572316(+) m6A 3'UTR       26404942 chr2:163572353-163572354(+) m6A 3'UTR       26404942

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-122-3p
Interactor2: Hnf4a

Evidence Support:

Strong-Evidence	qPCR
Support Database	ViRBase

References:

PMID	31363036	Target region	None
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	Mouse liver tissue	Interactor2 expression	None
Description	Effect of HCV infection on HNF4A mRNA expression in the livers of Alb-uPA/Scid mice.