Basic Information:

  VIRBase ID:  

HHID00019441

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          TLR7:  NM_016562     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	TLR7
miRBase Accession/Entrez ID	MIMAT0004593	51284
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD74//TLR7-like

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR7	chrX:12894099(+) A-I      intronic chrX:12892292(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR7	chrX:12895719-12895720(+) m6A exon//intron       - chrX:12903645-12903646(+) m6A CDS       - chrX:12903656-12903657(+) m6A CDS       - chrX:12903695-12903696(+) m6A CDS       - chrX:12903723-12903724(+) m6A CDS       - chrX:12903760-12903761(+) m6A CDS       - chrX:12903775-12903776(+) m6A CDS       - chrX:12903784-12903785(+) m6A CDS       - chrX:12903823-12903824(+) m6A CDS       - chrX:12903832-12903833(+) m6A CDS       - chrX:12903862-12903863(+) m6A CDS       - chrX:12903887-12903888(+) m6A CDS       - chrX:12903892-12903893(+) m6A CDS       - chrX:12903952-12903953(+) m6A CDS       - chrX:12903983-12903984(+) m6A CDS       - chrX:12904001-12904002(+) m6A CDS       - chrX:12904036-12904037(+) m6A CDS       - chrX:12904136-12904137(+) m6A CDS       - chrX:12904171-12904172(+) m6A CDS       - chrX:12904231-12904232(+) m6A CDS       - chrX:12904313-12904314(+) m6A CDS       - chrX:12904561-12904562(+) m6A CDS       - chrX:12904571-12904572(+) m6A CDS       - chrX:12904580-12904581(+) m6A CDS       - chrX:12904597-12904598(+) m6A CDS       - chrX:12904682-12904683(+) m6A CDS       - chrX:12904880-12904881(+) m6A CDS       - chrX:12904892-12904893(+) m6A CDS       - chrX:12904974-12904975(+) m6A CDS       - chrX:12904994-12904995(+) m6A CDS       - chrX:12905009-12905010(+) m6A CDS       - chrX:12905062-12905063(+) m6A CDS       - chrX:12905115-12905116(+) m6A CDS       - chrX:12905220-12905221(+) m6A CDS       - chrX:12905269-12905270(+) m6A CDS       - chrX:12905327-12905328(+) m6A CDS       - chrX:12905395-12905396(+) m6A CDS       - chrX:12905407-12905408(+) m6A CDS       - chrX:12905426-12905427(+) m6A CDS       - chrX:12905469-12905470(+) m6A CDS       - chrX:12905493-12905494(+) m6A CDS       - chrX:12905593-12905594(+) m6A CDS       - chrX:12905708-12905709(+) m6A CDS       - chrX:12905725-12905726(+) m6A CDS       - chrX:12905733-12905734(+) m6A CDS       - chrX:12905740-12905741(+) m6A CDS       - chrX:12905919-12905920(+) m6A CDS       - chrX:12906289-12906290(+) m6A CDS       - chrX:12906328-12906329(+) m6A CDS       - chrX:12906371-12906372(+) m6A CDS       - chrX:12906379-12906380(+) m6A CDS       - chrX:12906392-12906393(+) m6A CDS       - chrX:12906421-12906422(+) m6A CDS       - chrX:12906451-12906452(+) m6A CDS       - chrX:12906483-12906484(+) m6A CDS       - chrX:12906502-12906503(+) m6A CDS       - chrX:12906516-12906517(+) m6A CDS       - chrX:12907879-12907880(+) m6A 3'UTR       - chrX:12907958-12907959(+) m6A 3'UTR       - chrX:12907971-12907972(+) m6A 3'UTR       - chrX:12908075-12908076(+) m6A 3'UTR       - chrX:12908089-12908090(+) m6A 3'UTR       - chrX:12908119-12908120(+) m6A 3'UTR       - chrX:12908141-12908142(+) m6A 3'UTR       - chrX:12908153-12908154(+) m6A 3'UTR       - chrX:12908159-12908160(+) m6A 3'UTR       - chrX:12908218-12908219(+) m6A 3'UTR       - chrX:12908283-12908284(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TLR7	Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: TLR7

Evidence Support:

Strong-Evidence	qRT-PCR
Support Database	ViRBase

References:

PMID	30974864	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Huh7.5.1 cells	Interactor2 expression	None
Description	The selected six upregulated genes following miR-130a overexpression: (E) DHX58; (F) CD86; (G) IL6; (H) MX1; (I) PYCARD; and (J) TLR7.