Detail Information

Basic Information:


  VIRBase ID:  

HHID00019440

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           PYCARD:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p PYCARD
miRBase
Accession/Entrez ID		 MIMAT0004593 29108
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ASC//CARD5//TMS//TMS-1//TMS1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PYCARD
chr16:31212921-31212922(-) m6A CDS//exon       25456834//24981863
chr16:31212969-31212970(-) m6A CDS//exon       25456834//24981863
chr16:31212979-31212980(-) m6A CDS//exon       25456834//24981863
chr16:31212984-31212985(-) m6A CDS//exon       25456834//24981863
chr16:31213146-31213147(-) m6A CDS//exon       -
chr16:31213582-31213583(-) m6A CDS//exon//intron       -
chr16:31213824-31213825(-) m6A CDS       27371828
chr16:31213859-31213860(-) m6A CDS       27371828
chr16:31213970-31213971(-) m6A CDS       27371828
chr16:31214120-31214121(-) m6A 5'UTR       25456834
chr16:31214141-31214142(-) m6A 5'UTR       25456834
chr16:31214185-31214186(-) m6A 5'UTR       25456834
chr16:31214316-31214317(-) m6A 5'UTR       25456834
chr16:31214372-31214373(-) m6A 5'UTR       25456834
chr16:31214430-31214431(-) m6A 5'UTR       -
chr16:31214575-31214576(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PYCARD
Exosome Blood     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: PYCARD

Evidence Support:


Strong-Evidence qRT-PCR
Support Database ViRBase

References:


PMID 30974864 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh7.5.1 cells Interactor2 expression None
Description The selected six upregulated genes following miR-130a overexpression: (E) DHX58; (F) CD86; (G) IL6; (H) MX1; (I) PYCARD; and (J) TLR7.

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