Detail Information

Basic Information:


  VIRBase ID:  

HHID00019439

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           ATG5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p ATG5
miRBase
Accession/Entrez ID		 MIMAT0004593 9474
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - APG5//APG5-LIKE//APG5L//ASP//hAPG5//SCAR25

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ATG5
chr6:106691471(-) A-I      intronic
chr6:106672717(-) A-I      intronic
chr6:106672628(-) A-I      intronic
chr6:106669911(-) A-I      intronic
chr6:106655936(-) A-I      intronic
chr6:106650804(-) A-I      intronic
chr6:106650787(-) A-I      intronic
chr6:106650726(-) A-I      intronic
chr6:106648627(-) A-I      intronic
chr6:106648581(-) A-I      intronic
chr6:106646604(-) A-I      intronic
chr6:106646569(-) A-I      intronic
chr6:106646528(-) A-I      intronic
chr6:106646472(-) A-I      intronic
chr6:106646449(-) A-I      intronic
chr6:106725498(-) A-I      intronic
chr6:106725541(-) A-I      intronic
chr6:106744606(-) A-I      intronic
chr6:106744571(-) A-I      intronic
chr6:106725651(-) A-I      intronic
chr6:106726015(-) A-I      intronic
chr6:106726048(-) A-I      intronic
chr6:106726029(-) A-I      intronic
chr6:106746344(-) A-I      intronic
chr6:106746343(-) A-I      intronic
chr6:106746340(-) A-I      intronic
chr6:106746331(-) A-I      intronic
chr6:106744567(-) A-I      intronic
chr6:106744636(-) A-I      intronic
chr6:106744610(-) A-I      intronic
chr6:106699885(-) A-I      intronic
chr6:106699856(-) A-I      intronic
chr6:106669461(-) A-I      intronic
chr6:106738311(-) A-I      intronic
chr6:106691699(-) A-I      intronic
chr6:106725567(-) A-I      intronic
chr6:106646460(-) A-I      intronic
chr6:106648560(-) A-I      intronic
chr6:106669504(-) A-I      intronic
chr6:106646395(-) A-I      intronic
chr6:106725606(-) A-I      intronic
chr6:106650665(-) A-I      intronic
chr6:106691698(-) A-I      intronic
chr6:106691922(-) A-I      intronic
chr6:106745780(-) A-I      intronic
chr6:106646530(-) A-I      intronic
chr6:106650675(-) A-I      intronic
chr6:106669840(-) A-I      intronic
chr6:106637308(-) A-I      intronic
chr6:106648532(-) A-I      intronic
chr6:106725445(-) A-I      intronic
chr6:106745774(-) A-I      intronic
chr6:106648488(-) A-I      intronic
chr6:106642590(-) A-I      intronic
chr6:106755584(-) A-I      intronic
chr6:106738058(-) A-I      intronic
chr6:106726075(-) A-I      intronic
chr6:106744577(-) A-I      intronic
chr6:106670043(-) A-I      intronic
chr6:106646540(-) A-I      intronic
chr6:106745689(-) A-I      intronic
chr6:106725655(-) A-I      intronic
chr6:106746382(-) A-I      intronic
chr6:106642605(-) A-I      intronic
chr6:106755604(-) A-I      intronic
chr6:106725521(-) A-I      intronic
chr6:106650765(-) A-I      intronic
chr6:106645162(-) A-I      intronic
chr6:106755549(-) A-I      intronic
chr6:106646486(-) A-I      intronic
chr6:106669449(-) A-I      intronic
chr6:106755579(-) A-I      intronic
chr6:106646595(-) A-I      intronic
chr6:106743531(-) A-I      intronic
chr6:106655819(-) A-I      intronic
chr6:106646594(-) A-I      intronic
chr6:106655782(-) A-I      intronic
chr6:106669864(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ATG5
chr6:106646383(-) T-C intron -    22484847
chr6:106669449(-) A-G intron -    22484847
chr6:106669461(-) A-G intron -    22484847
chr6:106669582(-) C-T intron -    22484847
chr6:106669586(-) C-T intron -    22484847
chr6:106669840(-) A-G intron -    22484847
chr6:106669864(-) A-G intron -    22484847
chr6:106691698(-) A-G intron -    22484847
chr6:106691699(-) A-G intron -    22484847
chr6:106691892(-) A-G intron -    22484847
chr6:106691922(-) A-G intron -    22484847
chr6:106725606(-) A-G intron -    22484847
chr6:106725655(-) A-G intron -    22484847
chr6:106726075(-) A-G intron -    22484847
chr6:106744577(-) A-G intron -    22484847
chr6:106744581(-) A-G intron -    22484847
chr6:106745695(-) A-G intron -    22484847
chr6:106745774(-) A-G intron -    22484847
chr6:106745780(-) A-G intron -    22484847
chr6:106746382(-) A-G intron -    22484847
chr6:106755579(-) A-G intron -    22484847
chr6:106755584(-) A-G intron -    22484847
chr6:106755593(-) A-G intron -    22484847
chr6:106755599(-) A-G intron -    22484847
chr6:106755604(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ATG5
chr6:106633841-106633842(-) m6A 3'UTR//exon       27773535
chr6:106633918-106633919(-) m6A 3'UTR//exon       27773535
chr6:106634016-106634017(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr6:106634038-106634039(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr6:106634070-106634071(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:106634135-106634136(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:106634173-106634174(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:106634182-106634183(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:106634203-106634204(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:106634288-106634289(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:106634310-106634311(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:106634393-106634394(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr6:106634474-106634475(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr6:106634497-106634498(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
ATG5
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: ATG5

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 30974864 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh7.5.1 cells//Huh7.5.1 cells//JFH1 cells Interactor2 expression None
Description The four downregulated genes following miR-130a overexpression were confirmed by qPCR: (A) ATG5; These findings indicate that ATG5 is a target gene for miR-130a.

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