Basic Information:

  VIRBase ID:  

HHID00019438

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:  MIMAT0004593          MX1:  NM_001178046     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-130a-5p	MX1
miRBase Accession/Entrez ID	MIMAT0004593	4599
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFI-78K//IFI78//lncMX1-215//MX//MxA

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-130a-5p	rs746985078 chr11:57641223    A/G rs779670380 chr11:57641222    C/T rs758215186 chr11:57641219    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MX1	chr21:42801795(+) A-I      intronic chr21:42830098(+) A-I      intronic chr21:42828874(+) A-I      intronic chr21:42828825(+) A-I      intronic chr21:42828042(+) A-I      intronic chr21:42827914(+) A-I      intronic chr21:42820654(+) A-I      intronic chr21:42820641(+) A-I      intronic chr21:42820606(+) A-I      intronic chr21:42820581(+) A-I      intronic chr21:42820578(+) A-I      intronic chr21:42820575(+) A-I      intronic chr21:42820553(+) A-I      intronic chr21:42820547(+) A-I      intronic chr21:42820545(+) A-I      intronic chr21:42820521(+) A-I      intronic chr21:42819927(+) A-I      intronic chr21:42819916(+) A-I      intronic chr21:42819831(+) A-I      intronic chr21:42819737(+) A-I      intronic chr21:42799998(+) A-I      intronic chr21:42799926(+) A-I      intronic chr21:42799912(+) A-I      intronic chr21:42828091(+) A-I      intronic chr21:42828854(+) A-I      intronic chr21:42828032(+) A-I      intronic chr21:42801714(+) A-I      intronic chr21:42801785(+) A-I      intronic chr21:42799962(+) A-I      intronic chr21:42828092(+) A-I      intronic chr21:42799978(+) A-I      intronic chr21:42828067(+) A-I      intronic chr21:42828818(+) A-I      intronic chr21:42820469(+) A-I      intronic chr21:42801724(+) A-I      intronic chr21:42799907(+) A-I      intronic chr21:42827930(+) A-I      intronic chr21:42820483(+) A-I      intronic chr21:42828948(+) A-I      intronic chr21:42826908(+) A-I      intronic chr21:42828752(+) A-I      intronic chr21:42828872(+) A-I      intronic chr21:42820554(+) A-I      intronic chr21:42801646(+) A-I      intronic chr21:42799950(+) A-I      intronic chr21:42827991(+) A-I      intronic chr21:42819684(+) A-I      intronic chr21:42799897(+) A-I      intronic chr21:42801661(+) A-I      intronic chr21:42828011(+) A-I      intronic chr21:42819787(+) A-I      intronic chr21:42819854(+) A-I      intronic chr21:42830033(+) A-I      intronic chr21:42800035(+) A-I      intronic chr21:42819939(+) A-I      intronic chr21:42801780(+) A-I      intronic chr21:42828068(+) A-I      intronic chr21:42819899(+) A-I      intronic chr21:42820678(+) A-I      intronic chr21:42819686(+) A-I      intronic chr21:42823582(+) A-I      intronic chr21:42819763(+) A-I      intronic chr21:42819837(+) A-I      intronic chr21:42819798(+) A-I      intronic chr21:42799902(+) A-I      intronic chr21:42828961(+) A-I      intronic chr21:42800033(+) A-I      intronic chr21:42819758(+) A-I      intronic chr21:42819930(+) A-I      intronic chr21:42827891(+) A-I      intronic chr21:42819756(+) A-I      intronic chr21:42828048(+) A-I      intronic chr21:42819780(+) A-I      intronic chr21:42820715(+) A-I      intronic chr21:42828758(+) A-I      intronic chr21:42819795(+) A-I      intronic chr21:42819767(+) A-I      intronic chr21:42828886(+) A-I      intronic chr21:42828021(+) A-I      intronic chr21:42820478(+) A-I      intronic chr21:42827913(+) A-I      intronic chr21:42799974(+) A-I      intronic chr21:42827895(+) A-I      intronic chr21:42799982(+) A-I      intronic chr21:42801654(+) A-I      intronic chr21:42828891(+) A-I      intronic chr21:42828944(+) A-I      intronic chr21:42820525(+) A-I      intronic chr21:42801784(+) A-I      intronic chr21:42799980(+) A-I      intronic chr21:42801817(+) A-I      intronic chr21:42820477(+) A-I      intronic chr21:42819857(+) A-I      intronic chr21:42819814(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MX1	chr21:42799962(+) A-I intron -    22327324 chr21:42799972(+) A-I intron -    22327324 chr21:42799978(+) A-I intron -    22327324 chr21:42801714(+) A-I intron -    22327324 chr21:42801784(+) A-I intron -    22327324 chr21:42801785(+) A-I intron -    22327324 chr21:42819694(+) A-I intron -    22327324 chr21:42819756(+) A-I intron -    22327324 chr21:42819763(+) A-I intron -    22327324 chr21:42819767(+) A-I intron -    22327324 chr21:42819798(+) A-I intron -    22327324 chr21:42819857(+) A-I intron -    22327324 chr21:42819908(+) A-I intron -    22327324 chr21:42820469(+) A-I intron -    22327324 chr21:42820478(+) A-I intron -    22327324 chr21:42827913(+) A-I intron -    22327324 chr21:42828092(+) A-I intron -    22327324 chr21:42828818(+) A-I intron -    22327324 chr21:42828886(+) A-I intron -    22327324 chr21:42828891(+) A-I intron -    22327324 chr21:42828948(+) A-I intron -    22327324 chr21:42799864(+) A-G intron -    22484847 chr21:42799962(+) A-G intron -    22484847 chr21:42799972(+) A-G intron -    22484847 chr21:42799978(+) A-G intron -    22484847 chr21:42800022(+) A-G intron -    22484847 chr21:42801654(+) A-G intron -    22484847 chr21:42801714(+) A-G intron -    22484847 chr21:42801724(+) A-G intron -    22484847 chr21:42801784(+) A-G intron -    22484847 chr21:42801785(+) A-G intron -    22484847 chr21:42801831(+) C-A intron -    22484847 chr21:42803240(+) A-T intron -    22484847 chr21:42819694(+) A-G intron -    22484847 chr21:42819756(+) A-G intron -    22484847 chr21:42819763(+) A-G intron -    22484847 chr21:42819767(+) A-G intron -    22484847 chr21:42819780(+) A-G intron -    22484847 chr21:42819798(+) A-G intron -    22484847 chr21:42819837(+) A-G intron -    22484847 chr21:42819854(+) A-G intron -    22484847 chr21:42819857(+) A-G intron -    22484847 chr21:42819866(+) A-G intron -    22484847 chr21:42819908(+) A-G intron -    22484847 chr21:42819930(+) A-G intron -    22484847 chr21:42820469(+) A-G intron -    22484847 chr21:42820477(+) A-G intron -    22484847 chr21:42820478(+) A-G intron -    22484847 chr21:42820555(+) A-G intron -    22484847 chr21:42820642(+) A-G intron -    22484847 chr21:42820645(+) A-G intron -    22484847 chr21:42820715(+) A-G intron -    22484847 chr21:42827891(+) A-G intron -    22484847 chr21:42827895(+) A-G intron -    22484847 chr21:42827913(+) A-G intron -    22484847 chr21:42827991(+) A-G intron -    22484847 chr21:42827993(+) A-G intron -    22484847 chr21:42828068(+) A-G intron -    22484847 chr21:42828083(+) A-G intron -    22484847 chr21:42828092(+) A-G intron -    22484847 chr21:42828720(+) A-G intron -    22484847 chr21:42828752(+) A-G intron -    22484847 chr21:42828788(+) A-G intron -    22484847 chr21:42828789(+) A-G intron -    22484847 chr21:42828818(+) A-G intron -    22484847 chr21:42828872(+) A-G intron -    22484847 chr21:42828886(+) A-G intron -    22484847 chr21:42828891(+) A-G intron -    22484847 chr21:42828948(+) A-G intron -    22484847 chr21:42828949(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MX1	chr21:42795028-42795029(+) m6A exon//intron       - chr21:42795042-42795043(+) m6A exon//intron       - chr21:42795052-42795053(+) m6A exon//intron       25456834 chr21:42795119-42795120(+) m6A exon//intron       25456834 chr21:42795145-42795146(+) m6A exon//intron       25456834 chr21:42795175-42795176(+) m6A exon//intron       25456834 chr21:42795185-42795186(+) m6A exon//intron       25456834 chr21:42798186-42798187(+) m6A 5'UTR//exon//intron       - chr21:42799138-42799139(+) m6A 5'UTR//exon//intron       - chr21:42799176-42799177(+) m6A 5'UTR//exon//intron       - chr21:42821486-42821487(+) m6A exon//intron       - chr21:42821506-42821507(+) m6A exon//intron       - chr21:42821556-42821557(+) m6A exon//intron       - chr21:42821564-42821565(+) m6A exon//intron       - chr21:42830560-42830561(+) m6A CDS       - chr21:42830566-42830567(+) m6A CDS       - chr21:42830752-42830753(+) m6A 3'UTR       24981863 chr21:42830780-42830781(+) m6A 3'UTR       24981863 chr21:42830863-42830864(+) m6A 3'UTR       24981863 chr21:42830992-42830993(+) m6A 3'UTR       - chr21:42831007-42831008(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-130a-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	MX1	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-130a-5p	Eloxatine 5310940 Drug interaction    RC00006934 5-Fluorouracil 3385 Drug interaction    RC00006933

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-130a-5p	Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-130a-5p
Interactor2: MX1

Evidence Support:

Strong-Evidence	qRT-PCR
Support Database	ViRBase

References:

PMID	30974864	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Huh7.5.1 cells	Interactor2 expression	None
Description	The selected six upregulated genes following miR-130a overexpression: (E) DHX58; (F) CD86; (G) IL6; (H) MX1; (I) PYCARD; and (J) TLR7.