Detail Information

Basic Information:


  VIRBase ID:  

HHID00019437

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7802

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           IL18:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p IL18
miRBase
Accession/Entrez ID		 MIMAT0004593 3606
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IGIF//IL-18//IL-1g//IL1F4

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL18
chr11:112017188(-) A-I      intronic
chr11:112017172(-) A-I      intronic
chr11:112015080(-) A-I      intronic
chr11:112024780(-) A-I      intronic
chr11:112025166(-) A-I      intronic
chr11:112028812(-) A-I      intronic
chr11:112029935(-) A-I      intronic
chr11:112032460(-) A-I      intronic
chr11:112017336(-) A-I      intronic
chr11:112017266(-) A-I      intronic
chr11:112017251(-) A-I      intronic
chr11:112033235(-) A-I      intronic
chr11:112032466(-) A-I      intronic
chr11:112016228(-) A-I      intronic
chr11:112016340(-) A-I      intronic
chr11:112016350(-) A-I      intronic
chr11:112019811(-) A-I      intronic
chr11:112020003(-) A-I      intronic
chr11:112033218(-) A-I      intronic
chr11:112014064(-) A-I      3'UTR
chr11:112014187(-) A-I      3'UTR
chr11:112014294(-) A-I      3'UTR
chr11:112014132(-) A-I      3'UTR
chr11:112014127(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL18
chr11:112013997-112013998(-) m6A 3'UTR//exon       24981863//27773535
chr11:112014029-112014030(-) m6A 3'UTR//exon       24981863//27773535
chr11:112014197-112014198(-) m6A 3'UTR//exon       24981863//27773535
chr11:112014220-112014221(-) m6A 3'UTR//exon       24981863//27773535
chr11:112014322-112014323(-) m6A CDS//exon       24981863//26404942//27773535
chr11:112014387-112014388(-) m6A CDS//exon       24981863//26404942//27773535
chr11:112014397-112014398(-) m6A CDS//exon       24981863//26404942//27773535
chr11:112014468-112014469(-) m6A CDS//exon       26404942//27773535
chr11:112021170-112021171(-) m6A exon//intron       27773535
chr11:112021186-112021187(-) m6A exon//intron       27773535
chr11:112021217-112021218(-) m6A exon//intron       27773535
chr11:112021243-112021244(-) m6A exon//intron       27773535
chr11:112021317-112021318(-) m6A exon//intron       27773535
chr11:112021326-112021327(-) m6A exon//intron       27773535
chr11:112021366-112021367(-) m6A exon//intron       27773535
chr11:112023923-112023924(-) m1A exon//intron       26863196
chr11:112024064-112024065(-) m6A exon//intron       27773535
chr11:112024130-112024131(-) m6A exon//intron       24284625//24981863//27773535
chr11:112024182-112024183(-) m6A exon//intron       24284625//24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
IL18
Cytosol K562 cells     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: IL18

Evidence Support:


Strong-Evidence qRT-PCR
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 30974864 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh7.5.1 cells Interactor2 expression None
Description The four downregulated genes following miR-130a overexpression were confirmed by qPCR: (A) ATG5; (B) CASP1; (C) CD80; and (D) IL18.

Starting a new search, please wait ...