Detail Information

Basic Information:


  VIRBase ID:  

HHID00019435

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           CD86:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p CD86
miRBase
Accession/Entrez ID		 MIMAT0004593 942
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - B7-2//B7.2//B70//CD28LG2//LAB72

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CD86
chr3:121805311(+) A-I      intronic
chr3:121805340(+) A-I      intronic
chr3:121804361(+) A-I      intronic
chr3:121805433(+) A-I      intronic
chr3:121832936(+) A-I      intronic
chr3:121831309(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CD86
chr3:121782441(+) T-A intron -    22484847
chr3:121832917(+) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CD86
chr3:121839128-121839129(+) m6A 3'UTR       -
chr3:121839137-121839138(+) m6A 3'UTR       -
chr3:121839161-121839162(+) m6A 3'UTR       -
chr3:121839180-121839181(+) m6A 3'UTR       -
chr3:121839217-121839218(+) m6A 3'UTR       -
chr3:121839328-121839329(+) m6A 3'UTR       -
chr3:121839360-121839361(+) m6A 3'UTR       -
chr3:121839367-121839368(+) m6A 3'UTR       -
chr3:121839503-121839504(+) m6A 3'UTR       -
chr3:121839552-121839553(+) m6A 3'UTR       -
chr3:121839558-121839559(+) m6A 3'UTR       -
chr3:121839677-121839678(+) m6A 3'UTR       -
chr3:121839691-121839692(+) m6A 3'UTR       -
chr3:121839721-121839722(+) m6A 3'UTR       -
chr3:121839770-121839771(+) m6A 3'UTR       -
chr3:121839781-121839782(+) m6A 3'UTR       -
chr3:121839827-121839828(+) m6A 3'UTR       -
chr3:121839844-121839845(+) m6A 3'UTR       -
chr3:121839857-121839858(+) m6A 3'UTR       -
chr3:121839912-121839913(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
CD86
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: CD86

Evidence Support:


Strong-Evidence qRT-PCR
Support Database ViRBase

References:


PMID 30974864 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh7.5.1 cells Interactor2 expression None
Description The selected six upregulated genes following miR-130a overexpression: (E) DHX58; (F) CD86; (G) IL6; (H) MX1; (I) PYCARD; and (J) TLR7.

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