Detail Information

Basic Information:


  VIRBase ID:  

HHID00019433

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7802

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-130a-5p:           CASP1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-130a-5p CASP1
miRBase
Accession/Entrez ID		 MIMAT0004593 834
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ICE//IL1BC//P45

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-130a-5p
rs746985078 chr11:57641223    A/G
rs779670380 chr11:57641222    C/T
rs758215186 chr11:57641219    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CASP1
chr11:104899857(-) A-I      NonSyn:Thr->Ala
chr11:104906536(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CASP1
chr11:104905101-104905102(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:104905114-104905115(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:104905204-104905205(-) m6A 5'UTR//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-130a-5p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
CASP1
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-130a-5p
Eloxatine 5310940 Drug interaction    RC00006934
5-Fluorouracil 3385 Drug interaction    RC00006933
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-130a-5p
Tamoxifen 2733526       30840279

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-130a-5p
Interactor2: CASP1

Evidence Support:


Strong-Evidence qRT-PCR
Prediction-Evidence miRanda
Support Database ViRBase

References:


PMID 30974864 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Huh7.5.1 cells Interactor2 expression None
Description The four downregulated genes following miR-130a overexpression were confirmed by qPCR: (A) ATG5; (B) CASP1; (C) CD80; and (D) IL18.

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