Detail Information

Basic Information:


  VIRBase ID:  

HHID00019425

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-99a-3p:           SREBF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-99a-3p SREBF1
miRBase
Accession/Entrez ID		 MIMAT0004511 6720
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bHLHd1//HMD//IFAP2//SREBP1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-99a-3p
rs1214222916 chr21:16539147    T/C
rs1419616925 chr21:16539158    T/A
rs763134262 chr21:16539151    A/G
rs766428664 chr21:16539153    G/A
rs774748688 chr21:16539159    G/C
rs950382507 chr21:16539154    G/A
rs1271070422 chr21:16539142    C/T
rs913397001 chr21:16539145    G/A

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SREBF1
chr17:17729134(-) A-I      intronic
chr17:17729157(-) A-I      intronic
chr17:17737618(-) A-I      intronic
chr17:17737668(-) A-I      intronic
chr17:17737623(-) A-I      intronic
chr17:17736233(-) A-I      intronic
chr17:17729123(-) A-I      intronic
chr17:17729133(-) A-I      intronic
chr17:17737064(-) A-I      intronic
chr17:17733573(-) A-I      intronic
chr17:17732045(-) A-I      intronic
chr17:17732115(-) A-I      intronic
chr17:17732194(-) A-I      intronic
chr17:17732423(-) A-I      intronic
chr17:17733035(-) A-I      intronic
chr17:17733575(-) A-I      intronic
chr17:17737069(-) A-I      intronic
chr17:17737087(-) A-I      intronic
chr17:17737279(-) A-I      intronic
chr17:17737534(-) A-I      intronic
chr17:17737609(-) A-I      intronic
chr17:17737629(-) A-I      intronic
chr17:17737642(-) A-I      intronic
chr17:17738094(-) A-I      intronic
chr17:17738147(-) A-I      intronic
chr17:17738170(-) A-I      intronic
chr17:17738180(-) A-I      intronic
chr17:17737556(-) A-I      intronic
chr17:17736135(-) A-I      intronic
chr17:17736085(-) A-I      intronic
chr17:17737587(-) A-I      intronic
chr17:17732116(-) A-I      intronic
chr17:17732265(-) A-I      intronic
chr17:17736067(-) A-I      intronic
chr17:17736013(-) A-I      intronic
chr17:17732104(-) A-I      intronic
chr17:17729059(-) A-I      intronic
chr17:17733021(-) A-I      intronic
chr17:17737632(-) A-I      intronic
chr17:17733097(-) A-I      intronic
chr17:17737202(-) A-I      intronic
chr17:17729203(-) A-I      intronic
chr17:17735991(-) A-I      intronic
chr17:17738206(-) A-I      intronic
chr17:17729124(-) A-I      intronic
chr17:17736045(-) A-I      intronic
chr17:17732228(-) A-I      intronic
chr17:17737584(-) A-I      intronic
chr17:17737184(-) A-I      intronic
chr17:17737575(-) A-I      intronic
chr17:17737143(-) A-I      intronic
chr17:17737209(-) A-I      intronic
chr17:17737222(-) A-I      intronic
chr17:17737651(-) A-I      intronic
chr17:17733013(-) A-I      intronic
chr17:17733056(-) A-I      intronic
chr17:17732084(-) A-I      intronic
chr17:17737520(-) A-I      intronic
chr17:17737142(-) A-I      intronic
chr17:17737679(-) A-I      intronic
chr17:17737527(-) A-I      intronic
chr17:17732182(-) A-I      intronic
chr17:17732012(-) A-I      intronic
chr17:17732133(-) A-I      intronic
chr17:17733172(-) A-I      intronic
chr17:17731973(-) A-I      intronic
chr17:17732327(-) A-I      intronic
chr17:17732385(-) A-I      intronic
chr17:17733615(-) A-I      intronic
chr17:17737473(-) A-I      intronic
chr17:17733019(-) A-I      intronic
chr17:17737650(-) A-I      intronic
chr17:17732996(-) A-I      intronic
chr17:17737475(-) A-I      intronic
chr17:17737238(-) A-I      intronic
chr17:17737472(-) A-I      intronic
chr17:17736112(-) A-I      intronic
chr17:17733561(-) A-I      intronic
chr17:17732264(-) A-I      intronic
chr17:17736123(-) A-I      intronic
chr17:17737571(-) A-I      intronic
chr17:17732444(-) A-I      intronic
chr17:17733093(-) A-I      intronic
chr17:17733618(-) A-I      intronic
chr17:17737608(-) A-I      intronic
chr17:17738216(-) A-I      intronic
chr17:17733073(-) A-I      intronic
chr17:17737241(-) A-I      intronic
chr17:17738228(-) A-I      intronic
chr17:17737135(-) A-I      intronic
chr17:17732176(-) A-I      intronic
chr17:17733129(-) A-I      intronic
chr17:17733226(-) A-I      intronic
chr17:17732106(-) A-I      intronic
chr17:17733027(-) A-I      intronic
chr17:17737578(-) A-I      intronic
chr17:17738204(-) A-I      intronic
chr17:17733173(-) A-I      intronic
chr17:17732165(-) A-I      intronic
chr17:17737034(-) A-I      intronic
chr17:17732226(-) A-I      intronic
chr17:17736151(-) A-I      intronic
chr17:17737683(-) A-I      intronic
chr17:17737676(-) A-I      intronic
chr17:17732379(-) A-I      intronic
chr17:17736652(-) A-I      intronic
chr17:17728994(-) A-I      intronic
chr17:17733235(-) A-I      intronic
chr17:17733089(-) A-I      intronic
chr17:17736110(-) A-I      intronic
chr17:17737685(-) A-I      intronic
chr17:17737180(-) A-I      intronic
chr17:17733051(-) A-I      intronic
chr17:17735990(-) A-I      intronic
chr17:17735978(-) A-I      intronic
chr17:17737544(-) A-I      intronic
chr17:17733186(-) A-I      intronic
chr17:17737041(-) A-I      intronic
chr17:17737654(-) A-I      intronic
chr17:17737579(-) A-I      intronic
chr17:17737574(-) A-I      intronic
chr17:17733227(-) A-I      intronic
chr17:17737677(-) A-I      intronic
chr17:17729196(-) A-I      intronic
chr17:17729046(-) A-I      intronic
chr17:17738220(-) A-I      intronic
chr17:17738265(-) A-I      intronic
chr17:17731985(-) A-I      intronic
chr17:17718737(-) A-I      intronic
chr17:17724651(-) A-I      intronic
chr17:17738139(-) A-I      intronic
chr17:17732181(-) A-I      intronic
chr17:17737581(-) A-I      intronic
chr17:17733601(-) A-I      intronic
chr17:17733200(-) A-I      intronic
chr17:17732287(-) A-I      intronic
chr17:17737577(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SREBF1
chr17:17735978(-) A-I intron -    22028664
chr17:17735990(-) A-I intron -    22028664
chr17:17735991(-) A-I intron -    22028664
chr17:17736013(-) A-I intron -    22028664
chr17:17736045(-) A-I intron -    22028664
chr17:17736067(-) A-I intron -    22028664
chr17:17736123(-) A-I intron -    22028664
chr17:17736135(-) A-I intron -    22028664
chr17:17732226(-) A-I intron -    21960545
chr17:17733601(-) A-I intron -    21960545
chr17:17737608(-) A-I intron -    21960545
chr17:17716496(-) G-A intron -    22484847
chr17:17732106(-) A-G intron -    22484847
chr17:17732265(-) A-G intron -    22484847
chr17:17737677(-) A-G intron -    22484847
chr17:17737679(-) A-G intron -    22484847
chr17:17737683(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SREBF1
chr17:17714664-17714665(-) m6A 3'UTR       27773535
chr17:17714677-17714678(-) m6A 3'UTR       27773535
chr17:17714757-17714758(-) m6A 3'UTR       27773535
chr17:17715059-17715060(-) m6A 3'UTR//intron       24284625//27773535
chr17:17715072-17715073(-) m6A 3'UTR//intron       24284625//27773535
chr17:17715449-17715450(-) m6A 3'UTR//intron       -
chr17:17715573-17715574(-) m6A 3'UTR//intron       24284625//24981863
chr17:17715752-17715753(-) m6A 3'UTR//intron       24284625//25456834//24981863//22575960
chr17:17715833-17715834(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773536//22575960
chr17:17715934-17715935(-) m6A 3'UTR//intron       24284625//27773536
chr17:17715955-17715956(-) m6A 3'UTR//CDS//intron       24284625//27773536
chr17:17716296-17716297(-) m6A 3'UTR//intron       27773536
chr17:17716316-17716317(-) m6A 3'UTR//intron       27773536
chr17:17716580-17716581(-) m6A 3'UTR//intron       -
chr17:17716738-17716739(-) m6A 3'UTR//CDS//intron       24284625//27773536//22575960
chr17:17716934-17716935(-) m6A 3'UTR//CDS       24284625//27773536//22575960
chr17:17717598-17717599(-) m6A 3'UTR//CDS       27773536//22575960
chr17:17719552-17719553(-) m6A 3'UTR//CDS//exon       22575960
chr17:17719632-17719633(-) m6A 3'UTR//CDS//exon       27773536//22575960
chr17:17719853-17719854(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17719928-17719929(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17719952-17719953(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720027-17720028(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720281-17720282(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720505-17720506(-) m6A exon//intron       24284625
chr17:17720724-17720725(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720904-17720905(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//22575960
chr17:17720935-17720936(-) m6A 3'UTR//exon//intron       24284625//24981863//27371828//22575960
chr17:17721016-17721017(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr17:17721145-17721146(-) m6A CDS//exon       24284625//27371828//22575960
chr17:17721155-17721156(-) Gm CDS//exon       -
chr17:17721158-17721159(-) m6A CDS//exon       24284625//27371828//22575960
chr17:17721187-17721188(-) m6A CDS//exon       24284625//27371828//22575960
chr17:17721817-17721818(-) m6A exon//intron       -
chr17:17722018-17722019(-) m6A exon//intron       27773535
chr17:17722047-17722048(-) m6A exon//intron       27773535
chr17:17722647-17722648(-) m6A CDS//exon       22575960
chr17:17722710-17722711(-) m6A CDS//exon       22575960
chr17:17722736-17722737(-) m6A 5'UTR//CDS//exon       22575960
chr17:17723023-17723024(-) m6A 5'UTR//CDS//intron       24284625
chr17:17723106-17723107(-) m6A 5'UTR//intron       24284625
chr17:17723526-17723527(-) m6A 5'UTR//CDS//exon//intron       24284625//24981863//27773535//22575960
chr17:17723747-17723748(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828//22575960
chr17:17723807-17723808(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr17:17723834-17723835(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr17:17740246-17740247(-) m6A 5'UTR       24209618//25456834//24981863//27371828//27773536
chr17:17740287-17740288(-) m6A 5'UTR       24209618//25456834//24981863//27371828//27773536
chr17:17740303-17740304(-) m6A 5'UTR       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-99a-3p
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
SREBF1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-99a-3p
Interactor2: SREBF1

Evidence Support:


Strong-Evidence RT-qPCR//Western blot
Support Database ViRBase

References:


PMID 32605105 Target region None
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line Huh-7 cells Interactor2 expression Upregulation
Description We confirmed that the expression levels of both mRNA and protein of SREBP-1c were significantly down-regulated in FGR cells that were transfected with miR-99a-5p mimics (Figure 3A).

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