Detail Information

Basic Information:


  VIRBase ID:  

HHID00019423

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9797

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-193b-3p:           MCL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-193b-3p MCL1
miRBase
Accession/Entrez ID		 MIMAT0002819 4170
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bcl2-L-3//BCL2L3//EAT//Mcl-1//MCL1-ES//mcl1/EAT//MCL1L//MCL1S//TM

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-193b-3p
rs1442910742 chr16:14304030    A/T
rs371777083 chr16:14304035    C/T
rs760322270 chr16:14304034    C/T
rs776664516 chr16:14304037    C/T
rs1291785852 chr16:14304022    G/T
rs775353503 chr16:14304018    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MCL1
chr1:150547166-150547167(-) Y 3'UTR       25219674
chr1:150547424-150547425(-) m6A 3'UTR       24981863//26404942
chr1:150547472-150547473(-) m6A 3'UTR       26404942
chr1:150547590-150547591(-) Y 3'UTR       25219674
chr1:150547632-150547633(-) m6A 3'UTR       26404942
chr1:150547747-150547748(-) m6A 3'UTR       26404942
chr1:150547800-150547801(-) m6A 3'UTR       26404942
chr1:150547820-150547821(-) m6A 3'UTR       26404942
chr1:150547851-150547852(-) m6A 3'UTR       26404942
chr1:150547875-150547876(-) m6A 3'UTR       26404942
chr1:150547902-150547903(-) m6A 3'UTR       26404942
chr1:150547985-150547986(-) m6A 3'UTR       26404942
chr1:150548068-150548069(-) m6A 3'UTR       26404942
chr1:150548154-150548155(-) m6A 3'UTR       26404942
chr1:150548172-150548173(-) m6A 3'UTR       26404942
chr1:150548209-150548210(-) m6A 3'UTR       26404942
chr1:150548222-150548223(-) m6A 3'UTR       26404942
chr1:150548589-150548590(-) m6A 3'UTR       24981863//26404942
chr1:150548638-150548639(-) m6A 3'UTR       26404942
chr1:150549312-150549313(-) m6A 3'UTR       26404942
chr1:150549407-150549408(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:150549533-150549534(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549538-150549539(-) Y 3'UTR//exon       25219674
chr1:150549553-150549554(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549588-150549589(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549619-150549620(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549692-150549693(-) Tm 3'UTR//exon       -
chr1:150549779-150549780(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549797-150549798(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:150549935-150549936(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550731-150550732(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550744-150550745(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550754-150550755(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550791-150550792(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550810-150550811(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550817-150550818(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550827-150550828(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550876-150550877(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550948-150550949(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550953-150550954(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150550989-150550990(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551007-150551008(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551235-150551236(-) m6A exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551372-150551373(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551422-150551423(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150551449-150551450(-) Y CDS       26075521
chr1:150551791-150551792(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:150551973-150551974(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:150552109-150552110(-) m6A 5'UTR       -
chr1:150552124-150552125(-) m6A 5'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-193b-3p
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Plasma     24683445
Exosome B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Myotube     27396686
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Neural progenitor cells     21363885
MCL1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-193b-3p
S-Decyl p-toluenethiosulfonate 97461 Drug resistant
Benzethonium chloride 8478 Drug resistant
Jacaranone 73307 Drug resistant
(2S)-N-[(E,2S,4S,7S)-7-[[(2R)-2-Aminopropanoyl]amino]-4-formyl-5-(3-hydroxy-4-methoxyphenyl)-2-[[(Z)-3-(4-methoxyphenyl)-2-(methylamino)prop-2-enoyl]amino]-3,6,10-trioxodec-8-en-4-yl]-3-(4-hydroxyphenyl)-N-methyl-2-(methylamino)propanamide 6444175 Drug resistant
Xestin A 5352066 Drug resistant
Cyclosporin A 5284373 Drug resistant
4-Quinazolinamine, 2-[2-(1-pyrrolidinylazo)phenyl]- 424332 Drug resistant
Cbz-[Lys3]-Didemnin B 398464 Drug resistant
1H-Benz[g]indol-5-ol, 2-phenyl 371327 Drug resistant
Janus Red 3081985 Drug resistant
Tamoxifen 2733526 Drug resistant
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
Methyl (7E,9Z,11S,12R,13S,14R,15R,17R,18S,19S,20E)-2,16-diacetyloxy-11,12,14,18,19,31-hexahydroxy-3,7,11,13,17,19,21,27-octamethyl-6,28-dioxo-23,25-dioxa-5-azatetracyclo[20.7.1.14,29.026,30]hentriaconta-1,3,7,9,20,22(30),26,29(31)-octaene-15-carboxylate 138319233 Drug resistant
Triethyltin chloride 13820 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Berberine chloride 12456 Drug resistant
Litmomycin 12310334 Drug resistant
(1S,3R,7Z,9R,12S,13R,15S)-13-Butan-2-yl-13-hydroxy-3,7,12-trimethyl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 11972510 Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
1-o-octadecyl-2-methoxy-glycero-3-phosphocarnitine - Drug resistant
bafilomycin deriv - Drug resistant
michicarcin - Drug resistant
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-193b-3p
Hyaluronidase 91820602 Drug interaction    RC00005459
Oxaliplatine 6857599 Drug interaction    RC00005457
Gemcitabine 60750 Drug interaction    RC00005447
Progesterone 5994 Drug interaction    RC00005442
Vincristine 5978 Drug interaction    RC00005441
Estradiol 5757 Drug interaction    RC00005440
Mitomycin 5746 Drug interaction    RC00005439
Temozolomide 5394 Drug interaction    RC00005438
Eloxatine 5310940 Drug interaction    RC00005456
Imatinib 5291 Drug interaction    RC00005437
Decitabine 451668 Drug interaction    RC00005454
Docosahexaenoic acid 445580 Drug interaction    RC00005453
Cyclopamine 442972 Drug interaction    RC00005452
Carboplatinum 38904 Drug interaction    RC00005446
Paclitaxel 36314 Drug interaction    RC00005445
5-Fluorouracil 3385 Drug interaction    RC00005436
Enoxacin 3229 Drug interaction    RC00005435
Doxorubicin 31703 Drug interaction    RC00005444
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00005434
Tamoxifen 2733526 Drug interaction    RC00005455
Sorafenib 216239 Drug interaction    RC00005451
Arsenic trioxide 14888 Drug interaction    RC00005443
Docetaxel 148124 Drug interaction    RC00005450
Leucovorin 135403648 Drug interaction    RC00005460
Methotrexate 126941 Drug interaction    RC00005449
Ginsenoside Rh2 119307 Drug interaction    RC00005448
Abt-737 11228183 Drug interaction    RC00005458
Urokinase - Drug interaction    RC00005461
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00005462
Bio-Oss - Drug interaction    RC00005463
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-193b-3p
Cisplatin 5702198       25356050
5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-193b-3p
Interactor2: MCL1

Evidence Support:


Strong-Evidence Luciferase reporter assay//qPCR//Western blot
Weak-Evidence Microarray
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 20103677 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line Hep-394 cells//HepG2 cells//Huh7 cells Interactor2 expression Downregulation
Description Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes.Of these, miR-193b was over-expressed by 5-fold in Hep-394 cells. miR-193b was predicted to target Mcl-1, an anti-apoptotic protein that can modulate the response to sorafenib. The expression of Mcl-1 expression was decreased and basal caspase-3/7 activity and PARP cleavage were increased in Hep-394 cells compared to controls. Moreover, transfection with precursors to miR-193b decreased both Mcl-1 expression and the IC50 to sorafenib.

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