Basic Information:

  VIRBase ID:  

HHID00019422

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-431-5p:  MIMAT0001625          IFNB1:  NM_002176     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-431-5p	IFNB1
miRBase Accession/Entrez ID	MIMAT0001625	3456
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-431-5p	rs1174427606 chr14:100881041    C/T rs1309976089 chr14:100881036    G/C rs1478302726 chr14:100881040    T/C rs199509151 chr14:100881038    C/T rs749060583 chr14:100881039    G/A rs768621020 chr14:100881044    G/A rs774140527 chr14:100881046    A/G rs1238626395 chr14:100881032    G/A rs1458881469 chr14:100881033    C/T rs940385288 chr14:100881029    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNB1	chr9:21077198-21077199(-) m6A 3'UTR       27773535 chr9:21077273-21077274(-) m6A 3'UTR       27773535 chr9:21077278-21077279(-) m6A 3'UTR       27773535 chr9:21077308-21077309(-) m6A CDS       27773535 chr9:21077328-21077329(-) m6A CDS       27773535 chr9:21077347-21077348(-) m6A CDS       27773535 chr9:21077375-21077376(-) m6A CDS       27773535 chr9:21077592-21077593(-) m6A CDS       27773535 chr9:21077611-21077612(-) m6A CDS       27773535 chr9:21077695-21077696(-) m6A CDS       27773535 chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-431-5p	Exosome Serum     18589210 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Endothelial cells     - Microvesicle Fibroblasts|Mesenchymal stem cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-431-5p	Dichloroallyl lawsone 277767 Drug sensitive 1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-431-5p	Topotecan 60700 Drug interaction    RC00005069 Doxorubicin 31703 Drug interaction    RC00005068 Verapamil 2520 Drug interaction    RC00005067 Docetaxel 148124 Drug interaction    RC00005070 Chemotherapy - Drug interaction    RC00008866

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-431-5p
Interactor2: IFNB1

Evidence Support:

Strong-Evidence	RT-PCR
Weak-Evidence	Microarray
Support Database	VIRmiRNA

References:

PMID	17943132	Target region	None
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Huh7 cells	Interactor2 expression	None
Description	Transfection of the eight candidate miRNAs individually revealed that miRNAs miR-196, miR-296, miR-351, miR-431 and miR-448 were indeed able to substantially attenuate viral replication, whereas miRNAs miR-1, miR-30 and miR-128 were without effect (Fig. 2a). Transfection of a mixture of the five functional miRNA-mimics yielded a >80% reduction in viral RNA load. As IFNbeta induces miRNAs miR-196, miR-296, miR-351, miR-431 and miR-448 but downregulates miR-122, we decided to imitate this cellular response by transfecting the mix of miRNA-mimics in combination with anti-miR-122.