Basic Information:

  VIRBase ID:  

HHID00019374

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9751

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      NORAD:  NR_027451          WEE1:  NM_003390     

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Interactor Information:

	Interactor1	Interactor2
Symbol	NORAD	WEE1
miRBase Accession/Entrez ID	647979	7465
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	mRNA
Alias	LINC00657	WEE1A//WEE1hu

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt	PMID
LincSNP 3.0	NORAD	rs1204552 chr20:36050981 T/A         18488026 rs6142495 chr20:36047299 C/T         20881960 rs7265718 chr20:36047519 G/T         20881960 rs3171389 chr20:36048359 A/G         23474282

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WEE1	chr11:9606475(+) A-I      intronic chr11:9605083(+) A-I      intronic chr11:9606462(+) A-I      intronic chr11:9604300(+) A-I      intronic chr11:9613696(+) A-I      intronic chr11:9605000(+) A-I      intronic chr11:9604314(+) A-I      intronic chr11:9613706(+) A-I      intronic chr11:9613708(+) A-I      intronic chr11:9613740(+) A-I      intronic chr11:9613711(+) A-I      intronic chr11:9613720(+) A-I      intronic chr11:9613727(+) A-I      intronic chr11:9613689(+) A-I      intronic chr11:9606526(+) A-I      intronic chr11:9606469(+) A-I      intronic chr11:9605558(+) A-I      intronic chr11:9604279(+) A-I      intronic chr11:9604599(+) A-I      intronic chr11:9613653(+) A-I      intronic chr11:9604263(+) A-I      intronic chr11:9604679(+) A-I      intronic chr11:9604255(+) A-I      intronic chr11:9604214(+) A-I      intronic chr11:9604682(+) A-I      intronic chr11:9604749(+) A-I      intronic chr11:9604213(+) A-I      intronic chr11:9604684(+) A-I      intronic chr11:9604704(+) A-I      intronic chr11:9604708(+) A-I      intronic chr11:9605015(+) A-I      intronic chr11:9604739(+) A-I      intronic chr11:9603528(+) A-I      intronic chr11:9604907(+) A-I      intronic chr11:9605051(+) A-I      intronic chr11:9604915(+) A-I      intronic chr11:9605097(+) A-I      intronic chr11:9603485(+) A-I      intronic chr11:9604280(+) A-I      intronic chr11:9605122(+) A-I      intronic chr11:9605127(+) A-I      intronic chr11:9605576(+) A-I      intronic chr11:9606512(+) A-I      intronic chr11:9605451(+) A-I      intronic chr11:9604700(+) A-I      intronic chr11:9603472(+) A-I      intronic chr11:9605958(+) A-I      intronic chr11:9605573(+) A-I      intronic chr11:9605493(+) A-I      intronic chr11:9605529(+) A-I      intronic chr11:9604183(+) A-I      intronic chr11:9605640(+) A-I      intronic chr11:9605812(+) A-I      intronic chr11:9605824(+) A-I      intronic chr11:9605828(+) A-I      intronic chr11:9605844(+) A-I      intronic chr11:9605921(+) A-I      intronic chr11:9605927(+) A-I      intronic chr11:9605940(+) A-I      intronic chr11:9603466(+) A-I      intronic chr11:9606392(+) A-I      intronic chr11:9604585(+) A-I      intronic chr11:9606404(+) A-I      intronic chr11:9606409(+) A-I      intronic chr11:9611970(+) A-I      intronic chr11:9611966(+) A-I      intronic chr11:9604295(+) A-I      intronic chr11:9605627(+) A-I      intronic chr11:9606414(+) A-I      intronic chr11:9606488(+) A-I      intronic chr11:9604976(+) A-I      intronic chr11:9605954(+) A-I      intronic chr11:9611755(+) A-I      intronic chr11:9611769(+) A-I      intronic chr11:9611781(+) A-I      intronic chr11:9611965(+) A-I      intronic chr11:9605005(+) A-I      intronic chr11:9604175(+) A-I      intronic chr11:9604324(+) A-I      intronic chr11:9604695(+) A-I      intronic chr11:9605702(+) A-I      intronic chr11:9611989(+) A-I      intronic chr11:9611992(+) A-I      intronic chr11:9612004(+) A-I      intronic chr11:9613752(+) A-I      intronic chr11:9613754(+) A-I      intronic chr11:9604243(+) A-I      intronic chr11:9605822(+) A-I      intronic chr11:9604253(+) A-I      intronic chr11:9605009(+) A-I      intronic chr11:9605876(+) A-I      intronic chr11:9606563(+) A-I      intronic chr11:9605878(+) A-I      intronic chr11:9605655(+) A-I      intronic chr11:9611624(+) A-I      intronic chr11:9605041(+) A-I      intronic chr11:9604946(+) A-I      intronic chr11:9605967(+) A-I      intronic chr11:9604737(+) A-I      intronic chr11:9605882(+) A-I      intronic chr11:9606504(+) A-I      intronic chr11:9604374(+) A-I      intronic chr11:9606377(+) A-I      intronic chr11:9605734(+) A-I      intronic chr11:9604699(+) A-I      intronic chr11:9604643(+) A-I      intronic chr11:9605731(+) A-I      intronic chr11:9603462(+) A-I      intronic chr11:9605757(+) A-I      intronic chr11:9604843(+) A-I      intronic chr11:9606558(+) A-I      intronic chr11:9605654(+) A-I      intronic chr11:9604698(+) A-I      intronic chr11:9605628(+) A-I      intronic chr11:9605667(+) A-I      intronic chr11:9605932(+) A-I      intronic chr11:9604710(+) A-I      intronic chr11:9611942(+) A-I      intronic chr11:9606440(+) A-I      intronic chr11:9611943(+) A-I      intronic chr11:9605945(+) A-I      intronic chr11:9604240(+) A-I      intronic chr11:9604298(+) A-I      intronic chr11:9606562(+) A-I      intronic chr11:9605808(+) A-I      intronic chr11:9605714(+) A-I      intronic chr11:9605554(+) A-I      intronic chr11:9603475(+) A-I      intronic chr11:9606479(+) A-I      intronic chr11:9604177(+) A-I      intronic chr11:9606369(+) A-I      intronic chr11:9604373(+) A-I      intronic chr11:9606457(+) A-I      intronic chr11:9604835(+) A-I      intronic chr11:9604713(+) A-I      intronic chr11:9605931(+) A-I      intronic chr11:9605784(+) A-I      intronic chr11:9605593(+) A-I      intronic chr11:9604906(+) A-I      intronic chr11:9604717(+) A-I      intronic chr11:9605676(+) A-I      intronic chr11:9606583(+) A-I      intronic chr11:9614066(+) A-I      intronic chr11:9604630(+) A-I      intronic chr11:9606368(+) A-I      intronic chr11:9606446(+) A-I      intronic chr11:9604997(+) A-I      intronic chr11:9603540(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WEE1	chr11:9603462(+) A-I intron -    21960545 chr11:9605876(+) A-I intron -    21960545 chr11:9605882(+) A-I intron -    21960545 chr11:9606461(+) A-I intron -    21960545 chr11:9606488(+) A-I intron -    21960545 chr11:9606512(+) A-I intron -    21960545 chr11:9606562(+) A-I intron -    21960545 chr11:9606563(+) A-I intron -    21960545 chr11:9604183(+) A-G intron -    22484847 chr11:9604835(+) A-G intron -    22484847 chr11:9605882(+) A-G intron -    22484847 chr11:9606377(+) A-G intron -    22484847 chr11:9606440(+) A-G intron -    22484847 chr11:9606479(+) A-G intron -    22484847 chr11:9606512(+) A-G intron -    22484847 chr11:9606562(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WEE1	chr11:9595232-9595233(+) m6A 5'UTR       24209618//25456834//24981863 chr11:9595237-9595238(+) m6A 5'UTR       24209618//25456834//24981863 chr11:9595247-9595248(+) m6A 5'UTR       24209618//25456834//24981863 chr11:9595402-9595403(+) m6A 5'UTR       24209618 chr11:9595430-9595431(+) m6A 5'UTR       24209618 chr11:9595592-9595593(+) m1A CDS       26863196//26863410 chr11:9595634-9595635(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:9595754-9595755(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr11:9595985-9595986(+) m6A CDS       24209618 chr11:9596011-9596012(+) m6A CDS       24209618 chr11:9596262-9596263(+) m6A 5'UTR//intron       25456834 chr11:9608286-9608287(+) m6A 3'UTR//CDS//exon       24981863 chr11:9608349-9608350(+) m6A 3'UTR//CDS//exon       24981863 chr11:9609998-9609999(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr11:9610092-9610093(+) m6A 3'UTR//CDS//intron       24284625//22608085 chr11:9610120-9610121(+) m6A 3'UTR//CDS//intron       24284625//22608085 chr11:9610175-9610176(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr11:9610268-9610269(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr11:9610500-9610501(+) m6A 3'UTR//intron       24284625//24981863 chr11:9610523-9610524(+) m6A 3'UTR//intron       24284625//24981863 chr11:9610535-9610536(+) m6A 3'UTR//intron       24284625//24981863 chr11:9610608-9610609(+) m6A 3'UTR//intron       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NORAD	Cytoplasm EC tissues     32555178 Cytoplasm Human colon carcinoma-derived cell line (HCT-116)     26724866 Cytosol HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -
	WEE1	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	NORAD	6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide       9956222 Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-       9952773 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride       9938202 1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-, monohydrochloride       9926054 Tivozanib       9911830 Zibotentan       9910224 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide       9903786 PI-103       9884685 Osi-930       9868037 2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine       9858940 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-YL)-3-methyl-1H-pyrazol-5-YL]-6-ethylbenzene-1,3-diol       984170 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide       9826528 8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid       92577 Phenformin       8249 Bexarotene       82146 (E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one       78243717 N-(3-Methylphenyl)-4-pyridin-4-yl-1,3-thiazol-2-amine       704473 (S)-N-Hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide       6918848 Belinostat       6918638 Temsirolimus       6918289 Daporinad       6914657 N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide       6852167 AICA ribonucleotide       65110 Tanespimycin       6505803 Ispinesib mesylate       6450816 Axitinib       6450551 Piperlongumine       637858 (2-(Phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)       57339144 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea       56962337 2-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid       54685215 Lfm-a13       54676905 Temozolomide       5394 N-[4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide       53340664 Vorinostat       5311 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one       5278396 Bis(2-hydroxy-1-naphthyl) disulfide       521106 2-{[4-(5-Ethylpyrimidin-4-Yl)piperazin-1-Yl]methyl}-5-(Trifluoromethyl)-1h-Benzimidazole       51371303 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide       5113032 Tubastatin A       49850262 Alectinib       49806720 2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide       46943432 (S)-(+)-Tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate       46907787 3-(4-(4-(2-(3-((Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea       46885626 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine       46224516 N-(6,6-Dimethyl-5-(1-methylpiperidine-4-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-3-methylbutanamide       46191454 N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}benzenesulfonamide       447912 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine       44551660 Tretinoin       444795 Refametinib       44182295 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid       44137675 Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide       42640 Etoposide       36462 5-Fluorouracil       3385 Tamoxifen       2733526 [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol       25262965 2-(4-Methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide       25257557 Ruxolitinib       25126798 Navitoclax       24978538 MK-2206       24964624 Tert-Butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate       24951314 Quizartinib       24889392 Ponatinib       24826799 Bms-754807       24785538 Vismodegib       24776445 4-(6,6-Dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide       24772860 Cudc-101       24756910 Bicalutamide       2375 Olaparib       23725625 Lenalidomide       216326 Gsk-690693       16725726 Fedratinib       16722836 Docetaxel       148124 1-(Tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea       1401 (Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide       135659062 Pac-1       135421197 Osi-027       135398516 Akt inhibitor VIII       135398501 Methotrexate       126941 Lestaurtinib       126565 Veliparib       11960529 BAY 61-3606 dihydrochloride       11784504 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-YL)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide       11754511 Trametinib       11707110 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine       11647372 Idelalisib       11625818 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine       11617559 Benzamide, 4-((1R)-1-aminoethyl)-N-1H-pyrrolo(2,3-b)pyridin-4-yl-, hydrochloride (1:1)       11507964 5-(2-Phenylpyrazolo[1,5-A]pyridin-3-YL)-1H-pyrazolo[3,4-C]pyridazin-3-amine       11493598 Linifanib       11485656 N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide       11373846 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide       11338033 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one       11327430 Amuvatinib       11282283 (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide       11152667 7-Ethyl-10-hydroxycamptothecin       104842 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4h-Chromen-3-Yl 3,4-Di-O-Acetyl-6-Deoxy-alpha-L-Mannopyranoside       10459196 VX-702       10341154 Afatinib       10184653 Selumetinib       10127622 N-(3-{[5-Iodo-4-({3-[(Thiophen-2-Ylcarbonyl)amino]propyl}amino)pyrimidin-2-Yl]amino}phenyl)pyrrolidine-1-Carboxamide       10077147 Masitinib       10074640 Cetuximab       - Cisplatin       - Genentech Cpd 10       - JW-7-24-1       - KIN001-236       - KIN001-244       - KIN001-260       - KIN001-270       - NPK76-II-72-1       - Nutlin-3a (-)       - QL-X-138       - QL-XI-92       - QL-XII-47       - THZ-2-102-1       - THZ-2-49       - TL-1-85       - TL-2-105       - VNLG/124       - WZ3105       - XMD13-2       - XMD14-99       - XMD15-27       -

Interaction Network (The top 100 interactions):

Interactor1: NORAD
Interactor2: WEE1

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence	RNA-Seq
Support Database	ViRBase

References:

PMID	30089699	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Huh7.5 cells	Interactor2 expression	Upregulation
Description	Our study demonstrated several important findings: (i) Wee1 is a common target of both miR-373 and NORAD; (ii) Wee1 expression and NORAD expression are significantly upregulated in HCV-infected hepatocytes;.