Basic Information:

  VIRBase ID:  

HHID00019370

  Virus:  

Hepacivirus C (Hepatitis C virus JFH-1,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      GCSIR:  NR_038238          IFITM1:  NM_003641     

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Interactor Information:

	Interactor1	Interactor2
Symbol	GCSIR	IFITM1
miRBase Accession/Entrez ID	151484	8519
Organism	Homo sapiens	Homo sapiens
Category	lncRNA	mRNA
Alias	Lnc-ITM2C-1	9-27//CD225//DSPA2a//IFI17//LEU13

RNA Editing:

Resource	Symbol	Editing Position
Lncediting	GCSIR	chr22: 17134415     chr22: 17134007     chr22: 17134421     chr22: 17134422     chr22: 17134380     chr22: 17134379     chr22: 17134376     chr22: 17134365     chr22: 17134069     chr22: 17134066     chr22: 17134057     chr22: 17134046     chr22: 17134033     chr22: 17134363     chr22: 17134006     chr22: 17134331     chr22: 17134321     chr22: 17134312     chr22: 17134286     chr22: 17134285     chr22: 17134141     chr22: 17134131     chr22: 17134105     chr22: 17134089     chr22: 17134088     chr22: 17134070     chr22: 17129576     chr22: 17133999     chr22: 17129648     chr22: 17129631     chr22: 17129630     chr22: 17129625     chr22: 17129617     chr22: 17129605     chr22: 17134411     chr22: 17129598     chr22: 17129593     chr22: 17129579     chr22: 17129459     chr22: 17129561     chr22: 17129545     chr22: 17129535     chr22: 17129526     chr22: 17129525     chr22: 17129522     chr22: 17129513     chr22: 17129500     chr22: 17129476     chr22: 17129470     chr22: 17129460     chr22: 17129457     chr22: 17129452     chr22: 17134364     chr22: 17134427     chr22: 17134334     chr22: 17134431     chr22: 17134438     chr22: 17134448     chr22: 17134463     chr22: 17134467     chr22: 17134470     chr22: 17134492     chr22: 17134497     chr22: 17134395     chr22: 17134391     chr22: 17134390     chr22: 17134389     chr22: 17134385

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFITM1	chr11:315267(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFITM1	chr11:313992-313993(+) m6A 5'UTR//intron       25456834//24981863 chr11:314008-314009(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314036-314037(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314088-314089(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314120-314121(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314134-314135(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314184-314185(+) m6A CDS       24284625//25456834//24981863 chr11:314260-314261(+) m6A CDS       - chr11:314928-314929(+) m6A CDS//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IFITM1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: GCSIR
Interactor2: IFITM1

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	31200545	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	Huh7.5 cells	Interactor2 expression	Downregulation
Description	Figure 5.LncR 8 negatively regulates ISGs expression.