Basic Information:

  VIRBase ID:  

HHID00019367

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-4716-5p:  MIMAT0019826          NFKBIA:  NM_020529     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-4716-5p	NFKBIA
miRBase Accession/Entrez ID	MIMAT0019826	4792
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EDAID2//IKBA//MAD-3//NFKBI

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-4716-5p	rs1321858629 chr15:49169126    G/C rs187781917 chr15:49169133    G/A rs543052084 chr15:49169121    A/AGGAG

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NFKBIA	chr14:35870732-35870733(-) m6A 3'UTR       27773535 chr14:35870932-35870933(-) m6A 3'UTR       24981863//26404942//27773535 chr14:35870984-35870985(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535 chr14:35870995-35870996(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr14:35871038-35871039(-) m6A 3'UTR       24284625//25456834//24981863//26404942//27773535//22608085 chr14:35871128-35871129(-) Y 3'UTR       26075521 chr14:35871192-35871193(-) m6A 3'UTR//exon       24284625//24981863//28052920//26404942//27773535//27371828//22608085 chr14:35871198-35871199(-) m6A 3'UTR//exon       24284625//24981863//28052920//26404942//27773535//27371828//22608085 chr14:35871678-35871679(-) m6A 3'UTR//CDS//exon       24284625//26404942//27773535//22575960 chr14:35871828-35871829(-) m6A 3'UTR//CDS//exon//intron       27773535 chr14:35871850-35871851(-) m6A 3'UTR//CDS//exon//intron       27773535 chr14:35872480-35872481(-) m6A 3'UTR//CDS//exon       24284625//27773535//22575960 chr14:35872565-35872566(-) m6A CDS//exon       27773535//22575960 chr14:35872623-35872624(-) m6A exon//intron       27773535 chr14:35872908-35872909(-) m6A CDS//exon//intron       27773535 chr14:35872932-35872933(-) m6A CDS//exon//intron       27773535 chr14:35873151-35873152(-) m6A 5'UTR//intron       - chr14:35873626-35873627(-) m6A CDS//exon       27371828 chr14:35873746-35873747(-) m6A CDS//exon       24284625//26404942//27371828//27773536 chr14:35873786-35873787(-) m1A CDS//exon       26863196//26863410

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-4716-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NFKBIA	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-4716-5p
Interactor2: NFKBIA

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	miRNA array
Prediction-Evidence	miRanda//PicTar//RNAHybrid//Targetscan
Support Database	VIRmiRNA

References:

PMID	23418453	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Huh7.5 cells	Interactor2 expression	None
Description	Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.