Basic Information:

  VIRBase ID:  

HHID00019356

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-3p:  MIMAT0004551          VAV3:  NM_006113     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-3p	VAV3
miRBase Accession/Entrez ID	MIMAT0004551	10451
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-3p	rs1315913671 chr8:134804890    C/G rs1444509052 chr8:134804884    A/G rs1447612668 chr8:134804889    T/C rs185802410 chr8:134804886    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VAV3	chr1:108399545(-) A-I      intronic chr1:108122971(-) A-I      intronic chr1:108116568(-) A-I      intronic chr1:108488405(-) A-I      intronic chr1:108398043(-) A-I      intronic chr1:108488264(-) A-I      intronic chr1:108402923(-) A-I      intronic chr1:108398047(-) A-I      intronic chr1:108487406(-) A-I      intronic chr1:108487279(-) A-I      intronic chr1:108398181(-) A-I      intronic chr1:108398095(-) A-I      intronic chr1:108398094(-) A-I      intronic chr1:108402922(-) A-I      intronic chr1:108398014(-) A-I      intronic chr1:108401892(-) A-I      intronic chr1:108492180(-) A-I      intronic chr1:108121241(-) A-I      intronic chr1:108402921(-) A-I      intronic chr1:108401896(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	VAV3	chr1:108326519(-) T-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VAV3	chr1:108138861-108138862(-) m6A 3'UTR//CDS//exon       27773535 chr1:108138873-108138874(-) m6A 3'UTR//CDS//exon       27773535 chr1:108138914-108138915(-) m6A 3'UTR//CDS//exon       27773535 chr1:108138960-108138961(-) m6A 3'UTR//CDS//exon       24981863 chr1:108145745-108145746(-) m6A 3'UTR//CDS//exon       27773535 chr1:108145750-108145751(-) m6A 3'UTR//CDS//exon       27773535 chr1:108152086-108152087(-) m6A 3'UTR//intron       27773535 chr1:108211818-108211819(-) m6A 3'UTR//exon//intron       - chr1:108211870-108211871(-) m6A 3'UTR//exon//intron       - chr1:108231011-108231012(-) m6A CDS//exon//intron       24981863//27773535 chr1:108231019-108231020(-) m6A CDS//exon//intron       24981863//27773535 chr1:108231026-108231027(-) m6A CDS//exon//intron       24981863//27773535 chr1:108231074-108231075(-) m6A 5'UTR//exon//intron       24981863//27773535 chr1:108231127-108231128(-) m6A exon//intron       24981863 chr1:108247197-108247198(-) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	VAV3	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-3p
Interactor2: VAV3

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	miRNA array
Prediction-Evidence	miRanda//PicTar//RNAHybrid//Targetscan
Support Database	VIRmiRNA

References:

PMID	23418453	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Huh7.5 cells	Interactor2 expression	None
Description	Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.