Basic Information:

  VIRBase ID:  

HHID00019213

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          WWP1:  NM_007013     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	WWP1
miRBase Accession/Entrez ID	MIMAT0000245	11059
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIP5//hSDRP1//Tiul1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WWP1	chr8:87415586(+) A-I      intronic chr8:87476035(+) A-I      intronic chr8:87399845(+) A-I      intronic chr8:87476050(+) A-I      intronic chr8:87476043(+) A-I      intronic chr8:87394824(+) A-I      intronic chr8:87415573(+) A-I      intronic chr8:87370805(+) A-I      intronic chr8:87394837(+) A-I      intronic chr8:87394839(+) A-I      intronic chr8:87476040(+) A-I      intronic chr8:87477690(+) A-I      intronic chr8:87399987(+) A-I      intronic chr8:87387104(+) A-I      intronic chr8:87414534(+) A-I      intronic chr8:87476028(+) A-I      intronic chr8:87475732(+) A-I      intronic chr8:87475697(+) A-I      intronic chr8:87475685(+) A-I      intronic chr8:87363626(+) A-I      intronic chr8:87363624(+) A-I      intronic chr8:87399982(+) A-I      intronic chr8:87363611(+) A-I      intronic chr8:87387131(+) A-I      intronic chr8:87475653(+) A-I      intronic chr8:87463358(+) A-I      intronic chr8:87463264(+) A-I      intronic chr8:87463263(+) A-I      intronic chr8:87415556(+) A-I      intronic chr8:87463262(+) A-I      intronic chr8:87459535(+) A-I      intronic chr8:87442767(+) A-I      intronic chr8:87387177(+) A-I      intronic chr8:87388669(+) A-I      intronic chr8:87421537(+) A-I      intronic chr8:87421592(+) A-I      intronic chr8:87421602(+) A-I      intronic chr8:87421855(+) A-I      intronic chr8:87394766(+) A-I      intronic chr8:87399975(+) A-I      intronic chr8:87399962(+) A-I      intronic chr8:87399872(+) A-I      intronic chr8:87399854(+) A-I      intronic chr8:87476848(+) A-I      intronic chr8:87406775(+) A-I      intronic chr8:87406758(+) A-I      intronic chr8:87395851(+) A-I      intronic chr8:87476815(+) A-I      intronic chr8:87476163(+) A-I      intronic chr8:87476159(+) A-I      intronic chr8:87476128(+) A-I      intronic chr8:87399926(+) A-I      intronic chr8:87421969(+) A-I      intronic chr8:87442565(+) A-I      intronic chr8:87421970(+) A-I      intronic chr8:87421995(+) A-I      intronic chr8:87476034(+) A-I      intronic chr8:87421947(+) A-I      intronic chr8:87421943(+) A-I      intronic chr8:87421940(+) A-I      intronic chr8:87421939(+) A-I      intronic chr8:87476884(+) A-I      intronic chr8:87476849(+) A-I      intronic chr8:87477702(+) A-I      intronic chr8:87399805(+) A-I      intronic chr8:87395860(+) A-I      intronic chr8:87394877(+) A-I      intronic chr8:87477704(+) A-I      intronic chr8:87394856(+) A-I      intronic chr8:87394787(+) A-I      intronic chr8:87394775(+) A-I      intronic chr8:87409064(+) A-I      intronic chr8:87421543(+) A-I      intronic chr8:87405657(+) A-I      intronic chr8:87442697(+) A-I      intronic chr8:87421516(+) A-I      intronic chr8:87422009(+) A-I      intronic chr8:87463385(+) A-I      intronic chr8:87371006(+) A-I      intronic chr8:87476824(+) A-I      intronic chr8:87376888(+) A-I      intronic chr8:87442639(+) A-I      intronic chr8:87398545(+) A-I      intronic chr8:87463186(+) A-I      intronic chr8:87399871(+) A-I      intronic chr8:87399936(+) A-I      intronic chr8:87399881(+) A-I      intronic chr8:87372024(+) A-I      intronic chr8:87451685(+) A-I      intronic chr8:87476205(+) A-I      intronic chr8:87442596(+) A-I      intronic chr8:87376924(+) A-I      intronic chr8:87475616(+) A-I      intronic chr8:87476928(+) A-I      intronic chr8:87477703(+) A-I      intronic chr8:87476125(+) A-I      intronic chr8:87476277(+) A-I      intronic chr8:87451686(+) A-I      intronic chr8:87451318(+) A-I      intronic chr8:87376885(+) A-I      intronic chr8:87399868(+) A-I      intronic chr8:87442359(+) A-I      intronic chr8:87475636(+) A-I      intronic chr8:87421888(+) A-I      intronic chr8:87399958(+) A-I      intronic chr8:87476179(+) A-I      intronic chr8:87476219(+) A-I      intronic chr8:87365986(+) A-I      intronic chr8:87451689(+) A-I      intronic chr8:87405555(+) A-I      intronic chr8:87475796(+) A-I      intronic chr8:87475665(+) A-I      intronic chr8:87477824(+) A-I      intronic chr8:87477782(+) A-I      intronic chr8:87434047(+) A-I      intronic chr8:87405497(+) A-I      intronic chr8:87399792(+) A-I      intronic chr8:87451608(+) A-I      intronic chr8:87376921(+) A-I      intronic chr8:87476874(+) A-I      intronic chr8:87475735(+) A-I      intronic chr8:87360577(+) A-I      intronic chr8:87476830(+) A-I      intronic chr8:87463386(+) A-I      intronic chr8:87476278(+) A-I      intronic chr8:87475715(+) A-I      intronic chr8:87414615(+) A-I      intronic chr8:87451317(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WWP1	chr8:87476277(+) A-I intron -    22327324 chr8:87394744(+) A-I intron -    21960545 chr8:87394766(+) A-I intron -    21960545 chr8:87395824(+) A-I intron -    21960545 chr8:87405606(+) A-I intron -    21960545 chr8:87406737(+) A-I intron -    21960545 chr8:87406812(+) A-I intron -    21960545 chr8:87407791(+) A-I intron -    21960545 chr8:87407811(+) A-I intron -    21960545 chr8:87407836(+) A-I intron -    21960545 chr8:87407851(+) A-I intron -    21960545 chr8:87408881(+) A-I intron -    21960545 chr8:87448407(+) A-I intron -    21960545 chr8:87449171(+) A-I intron -    21960545 chr8:87449217(+) A-I intron -    21960545 chr8:87451622(+) A-I intron -    21960545 chr8:87475653(+) A-I intron -    21960545 chr8:87475665(+) A-I intron -    21960545 chr8:87476824(+) A-I intron -    21960545 chr8:87476874(+) A-I intron -    21960545 chr8:87477704(+) A-I intron -    21960545 chr8:87477708(+) A-I intron -    21960545 chr8:87477724(+) A-I intron -    21960545 chr8:87371006(+) A-G intron -    22484847 chr8:87394751(+) A-G intron -    22484847 chr8:87395745(+) C-G intron -    22484847 chr8:87400497(+) C-T intron -    22484847 chr8:87414615(+) A-G intron -    22484847 chr8:87442301(+) A-G intron -    22484847 chr8:87442359(+) A-G intron -    22484847 chr8:87442411(+) T-C intron -    22484847 chr8:87442596(+) A-G intron -    22484847 chr8:87442697(+) A-G intron -    22484847 chr8:87444917(+) A-G intron -    22484847 chr8:87473059(+) G-T intron -    22484847 chr8:87473092(+) G-A intron -    22484847 chr8:87475567(+) A-G intron -    22484847 chr8:87475636(+) A-G intron -    22484847 chr8:87475665(+) A-G intron -    22484847 chr8:87475723(+) T-C intron -    22484847 chr8:87476125(+) A-G intron -    22484847 chr8:87476205(+) A-G intron -    22484847 chr8:87476277(+) A-G intron -    22484847 chr8:87476824(+) A-G intron -    22484847 chr8:87476830(+) A-G intron -    22484847 chr8:87477786(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WWP1	chr8:87410586-87410587(+) m6A CDS//exon       24981863 chr8:87410595-87410596(+) m6A CDS//exon       24981863 chr8:87410609-87410610(+) m6A CDS//exon       24981863 chr8:87410629-87410630(+) m6A CDS//exon       24981863 chr8:87410687-87410688(+) m6A CDS//exon       24981863 chr8:87447906-87447907(+) m6A CDS//exon       - chr8:87450827-87450828(+) m6A CDS//exon       - chr8:87479229-87479230(+) m6A 3'UTR//intron       22608085 chr8:87479273-87479274(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr8:87479362-87479363(+) m6A 3'UTR//intron       24981863//22608085 chr8:87479394-87479395(+) m6A 3'UTR//intron       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	WWP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: WWP1

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	miRNA array
Prediction-Evidence	miRanda//PicTar//RNAHybrid//Targetscan
Support Database	VIRmiRNA

References:

PMID	23418453	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Huh7.5 cells	Interactor2 expression	None
Description	Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.