Detail Information

Basic Information:


  VIRBase ID:  

HHID00019211

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           VAV3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p VAV3
miRBase
Accession/Entrez ID		 MIMAT0000245 10451
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VAV3
chr1:108399545(-) A-I      intronic
chr1:108122971(-) A-I      intronic
chr1:108116568(-) A-I      intronic
chr1:108488405(-) A-I      intronic
chr1:108398043(-) A-I      intronic
chr1:108488264(-) A-I      intronic
chr1:108402923(-) A-I      intronic
chr1:108398047(-) A-I      intronic
chr1:108487406(-) A-I      intronic
chr1:108487279(-) A-I      intronic
chr1:108398181(-) A-I      intronic
chr1:108398095(-) A-I      intronic
chr1:108398094(-) A-I      intronic
chr1:108402922(-) A-I      intronic
chr1:108398014(-) A-I      intronic
chr1:108401892(-) A-I      intronic
chr1:108492180(-) A-I      intronic
chr1:108121241(-) A-I      intronic
chr1:108402921(-) A-I      intronic
chr1:108401896(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED VAV3
chr1:108326519(-) T-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VAV3
chr1:108138861-108138862(-) m6A 3'UTR//CDS//exon       27773535
chr1:108138873-108138874(-) m6A 3'UTR//CDS//exon       27773535
chr1:108138914-108138915(-) m6A 3'UTR//CDS//exon       27773535
chr1:108138960-108138961(-) m6A 3'UTR//CDS//exon       24981863
chr1:108145745-108145746(-) m6A 3'UTR//CDS//exon       27773535
chr1:108145750-108145751(-) m6A 3'UTR//CDS//exon       27773535
chr1:108152086-108152087(-) m6A 3'UTR//intron       27773535
chr1:108211818-108211819(-) m6A 3'UTR//exon//intron       -
chr1:108211870-108211871(-) m6A 3'UTR//exon//intron       -
chr1:108231011-108231012(-) m6A CDS//exon//intron       24981863//27773535
chr1:108231019-108231020(-) m6A CDS//exon//intron       24981863//27773535
chr1:108231026-108231027(-) m6A CDS//exon//intron       24981863//27773535
chr1:108231074-108231075(-) m6A 5'UTR//exon//intron       24981863//27773535
chr1:108231127-108231128(-) m6A exon//intron       24981863
chr1:108247197-108247198(-) m6A CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
VAV3
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: VAV3

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence miRNA array
Prediction-Evidence miRanda//PicTar//RNAHybrid//Targetscan
Support Database VIRmiRNA

References:


PMID 23418453 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Huh7.5 cells Interactor2 expression None
Description Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.

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