Detail Information

Basic Information:


  VIRBase ID:  

HHID00019209

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           ARHGEF6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p ARHGEF6
miRBase
Accession/Entrez ID		 MIMAT0000245 9459
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - alpha-PIX//alphaPIX//Cool-2//COOL2//MRX46//PIXA

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ARHGEF6
chrX:135806516(-) A-I      intronic
chrX:135806412(-) A-I      intronic
chrX:135806403(-) A-I      intronic
chrX:135806390(-) A-I      intronic
chrX:135806377(-) A-I      intronic
chrX:135806371(-) A-I      intronic
chrX:135806363(-) A-I      intronic
chrX:135806347(-) A-I      intronic
chrX:135806341(-) A-I      intronic
chrX:135806331(-) A-I      intronic
chrX:135806324(-) A-I      intronic
chrX:135806008(-) A-I      intronic
chrX:135805949(-) A-I      intronic
chrX:135805820(-) A-I      intronic
chrX:135795896(-) A-I      intronic
chrX:135787388(-) A-I      intronic
chrX:135787387(-) A-I      intronic
chrX:135787348(-) A-I      intronic
chrX:135778606(-) A-I      intronic
chrX:135778554(-) A-I      intronic
chrX:135778537(-) A-I      intronic
chrX:135776323(-) A-I      intronic
chrX:135806825(-) A-I      intronic
chrX:135806819(-) A-I      intronic
chrX:135806457(-) A-I      intronic
chrX:135806415(-) A-I      intronic
chrX:135805984(-) A-I      intronic
chrX:135805975(-) A-I      intronic
chrX:135805962(-) A-I      intronic
chrX:135805960(-) A-I      intronic
chrX:135841554(-) A-I      intronic
chrX:135840385(-) A-I      intronic
chrX:135840338(-) A-I      intronic
chrX:135840334(-) A-I      intronic
chrX:135840302(-) A-I      intronic
chrX:135839381(-) A-I      intronic
chrX:135839267(-) A-I      intronic
chrX:135809920(-) A-I      intronic
chrX:135809909(-) A-I      intronic
chrX:135809894(-) A-I      intronic
chrX:135806832(-) A-I      intronic
chrX:135806827(-) A-I      intronic
chrX:135806820(-) A-I      intronic
chrX:135748679(-) A-I      3'UTR
chrX:135748659(-) A-I      3'UTR
chrX:135748671(-) A-I      3'UTR
chrX:135748599(-) A-I      3'UTR
chrX:135748607(-) A-I      3'UTR
chrX:135748612(-) A-I      3'UTR
chrX:135748617(-) A-I      3'UTR
chrX:135748661(-) A-I      3'UTR
chrX:135748639(-) A-I      3'UTR
chrX:135748643(-) A-I      3'UTR
chrX:135840382(-) A-I      intronic
chrX:135776376(-) A-I      intronic
chrX:135767680(-) A-I      intronic
chrX:135839407(-) A-I      intronic
chrX:135806921(-) A-I      intronic
chrX:135805900(-) A-I      intronic
chrX:135839397(-) A-I      intronic
chrX:135791961(-) A-I      intronic
chrX:135839436(-) A-I      intronic
chrX:135839259(-) A-I      intronic
chrX:135806788(-) A-I      intronic
chrX:135841533(-) A-I      intronic
chrX:135792003(-) A-I      intronic
chrX:135806509(-) A-I      intronic
chrX:135806872(-) A-I      intronic
chrX:135839291(-) A-I      intronic
chrX:135839554(-) A-I      intronic
chrX:135839356(-) A-I      intronic
chrX:135840444(-) A-I      intronic
chrX:135806734(-) A-I      intronic
chrX:135776411(-) A-I      intronic
chrX:135839467(-) A-I      intronic
chrX:135806822(-) A-I      intronic
chrX:135806752(-) A-I      intronic
chrX:135811806(-) A-I      intronic
chrX:135785784(-) A-I      intronic
chrX:135806421(-) A-I      intronic
chrX:135840415(-) A-I      intronic
chrX:135787261(-) A-I      intronic
chrX:135806826(-) A-I      intronic
chrX:135806418(-) A-I      intronic
chrX:135840374(-) A-I      intronic
chrX:135806848(-) A-I      intronic
chrX:135839525(-) A-I      intronic
chrX:135841706(-) A-I      intronic
chrX:135806015(-) A-I      intronic
chrX:135840482(-) A-I      intronic
chrX:135805997(-) A-I      intronic
chrX:135844238(-) A-I      intronic
chrX:135844926(-) A-I      intronic
chrX:135811734(-) A-I      intronic
chrX:135809944(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ARHGEF6
chrX:135767680(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ARHGEF6
chrX:135747892-135747893(-) Y 3'UTR       26075521
chrX:135750204-135750205(-) m6A CDS       27371828
chrX:135750240-135750241(-) m6A CDS       27371828
chrX:135750275-135750276(-) m6A CDS       27371828
chrX:135750292-135750293(-) m6A CDS       28052920//27371828
chrX:135751649-135751650(-) m6A CDS       28052920//27371828
chrX:135754194-135754195(-) m6A CDS       27371828
chrX:135754212-135754213(-) m6A CDS       27371828
chrX:135754228-135754229(-) m6A CDS       27371828
chrX:135849325-135849326(-) m6A 5'UTR//intron       27773536
chrX:135850586-135850587(-) m6A 5'UTR//intron       -
chrX:135850598-135850599(-) m6A 5'UTR//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ARHGEF6
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: ARHGEF6

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence miRNA array
Prediction-Evidence miRanda//PicTar//RNAHybrid//Targetscan
Support Database VIRmiRNA

References:


PMID 23418453 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Huh7.5 cells Interactor2 expression None
Description Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.

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