Detail Information

Basic Information:


  VIRBase ID:  

HHID00019203

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           VAV2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p VAV2
miRBase
Accession/Entrez ID		 MIMAT0000245 7410
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - VAV-2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VAV2
chr9:136765061(-) A-I      intronic
chr9:136806467(-) A-I      intronic
chr9:136806899(-) A-I      intronic
chr9:136806902(-) A-I      intronic
chr9:136806952(-) A-I      intronic
chr9:136806972(-) A-I      intronic
chr9:136812610(-) A-I      intronic
chr9:136812654(-) A-I      intronic
chr9:136812734(-) A-I      intronic
chr9:136812984(-) A-I      intronic
chr9:136812996(-) A-I      intronic
chr9:136813008(-) A-I      intronic
chr9:136813089(-) A-I      intronic
chr9:136813107(-) A-I      intronic
chr9:136813126(-) A-I      intronic
chr9:136813131(-) A-I      intronic
chr9:136813140(-) A-I      intronic
chr9:136813150(-) A-I      intronic
chr9:136829225(-) A-I      intronic
chr9:136764434(-) A-I      intronic
chr9:136764686(-) A-I      intronic
chr9:136764706(-) A-I      intronic
chr9:136765043(-) A-I      intronic
chr9:136849867(-) A-I      intronic
chr9:136765096(-) A-I      intronic
chr9:136829237(-) A-I      intronic
chr9:136766197(-) A-I      intronic
chr9:136806362(-) A-I      intronic
chr9:136829361(-) A-I      intronic
chr9:136766060(-) A-I      intronic
chr9:136766086(-) A-I      intronic
chr9:136766091(-) A-I      intronic
chr9:136766100(-) A-I      intronic
chr9:136829368(-) A-I      intronic
chr9:136685543(-) A-I      intronic
chr9:136685557(-) A-I      intronic
chr9:136849156(-) A-I      intronic
chr9:136849226(-) A-I      intronic
chr9:136806364(-) A-I      intronic
chr9:136849892(-) A-I      intronic
chr9:136849258(-) A-I      intronic
chr9:136849270(-) A-I      intronic
chr9:136806446(-) A-I      intronic
chr9:136829356(-) A-I      intronic
chr9:136849940(-) A-I      intronic
chr9:136849947(-) A-I      intronic
chr9:136849967(-) A-I      intronic
chr9:136849984(-) A-I      intronic
chr9:136850439(-) A-I      intronic
chr9:136850571(-) A-I      intronic
chr9:136850572(-) A-I      intronic
chr9:136849272(-) A-I      intronic
chr9:136694798(-) A-I      intronic
chr9:136850579(-) A-I      intronic
chr9:136850581(-) A-I      intronic
chr9:136850631(-) A-I      intronic
chr9:136850677(-) A-I      intronic
chr9:136850685(-) A-I      intronic
chr9:136696476(-) A-I      intronic
chr9:136704675(-) A-I      intronic
chr9:136704736(-) A-I      intronic
chr9:136681755(-) A-I      intronic
chr9:136681768(-) A-I      intronic
chr9:136683243(-) A-I      intronic
chr9:136683297(-) A-I      intronic
chr9:136683319(-) A-I      intronic
chr9:136683376(-) A-I      intronic
chr9:136684023(-) A-I      intronic
chr9:136684083(-) A-I      intronic
chr9:136684094(-) A-I      intronic
chr9:136684113(-) A-I      intronic
chr9:136684139(-) A-I      intronic
chr9:136684373(-) A-I      intronic
chr9:136684385(-) A-I      intronic
chr9:136684399(-) A-I      intronic
chr9:136684459(-) A-I      intronic
chr9:136684463(-) A-I      intronic
chr9:136684502(-) A-I      intronic
chr9:136704746(-) A-I      intronic
chr9:136684507(-) A-I      intronic
chr9:136685550(-) A-I      intronic
chr9:136685584(-) A-I      intronic
chr9:136685590(-) A-I      intronic
chr9:136694786(-) A-I      intronic
chr9:136813106(-) A-I      intronic
chr9:136696385(-) A-I      intronic
chr9:136696496(-) A-I      intronic
chr9:136697783(-) A-I      intronic
chr9:136704635(-) A-I      intronic
chr9:136704658(-) A-I      intronic
chr9:136704748(-) A-I      intronic
chr9:136704749(-) A-I      intronic
chr9:136734041(-) A-I      intronic
chr9:136734257(-) A-I      intronic
chr9:136734610(-) A-I      intronic
chr9:136763467(-) A-I      intronic
chr9:136763494(-) A-I      intronic
chr9:136763519(-) A-I      intronic
chr9:136763538(-) A-I      intronic
chr9:136763592(-) A-I      intronic
chr9:136763607(-) A-I      intronic
chr9:136763996(-) A-I      intronic
chr9:136764082(-) A-I      intronic
chr9:136764148(-) A-I      intronic
chr9:136764177(-) A-I      intronic
chr9:136764210(-) A-I      intronic
chr9:136764216(-) A-I      intronic
chr9:136829358(-) A-I      intronic
chr9:136766104(-) A-I      intronic
chr9:136766124(-) A-I      intronic
chr9:136734216(-) A-I      intronic
chr9:136696475(-) A-I      intronic
chr9:136765299(-) A-I      intronic
chr9:136813017(-) A-I      intronic
chr9:136849973(-) A-I      intronic
chr9:136684508(-) A-I      intronic
chr9:136734301(-) A-I      intronic
chr9:136849268(-) A-I      intronic
chr9:136765315(-) A-I      intronic
chr9:136849231(-) A-I      intronic
chr9:136683257(-) A-I      intronic
chr9:136849996(-) A-I      intronic
chr9:136806325(-) A-I      intronic
chr9:136684071(-) A-I      intronic
chr9:136766059(-) A-I      intronic
chr9:136850568(-) A-I      intronic
chr9:136763545(-) A-I      intronic
chr9:136684005(-) A-I      intronic
chr9:136849678(-) A-I      intronic
chr9:136764422(-) A-I      intronic
chr9:136696506(-) A-I      intronic
chr9:136849673(-) A-I      intronic
chr9:136763604(-) A-I      intronic
chr9:136813009(-) A-I      intronic
chr9:136850605(-) A-I      intronic
chr9:136765307(-) A-I      intronic
chr9:136734251(-) A-I      intronic
chr9:136764637(-) A-I      intronic
chr9:136765177(-) A-I      intronic
chr9:136806304(-) A-I      intronic
chr9:136849492(-) A-I      intronic
chr9:136806863(-) A-I      intronic
chr9:136849190(-) A-I      intronic
chr9:136849613(-) A-I      intronic
chr9:136806285(-) A-I      intronic
chr9:136812605(-) A-I      intronic
chr9:136849127(-) A-I      intronic
chr9:136812659(-) A-I      intronic
chr9:136849491(-) A-I      intronic
chr9:136849232(-) A-I      intronic
chr9:136849864(-) A-I      intronic
chr9:136850024(-) A-I      intronic
chr9:136849918(-) A-I      intronic
chr9:136734258(-) A-I      intronic
chr9:136734271(-) A-I      intronic
chr9:136849970(-) A-I      intronic
chr9:136764740(-) A-I      intronic
chr9:136764453(-) A-I      intronic
chr9:136813060(-) A-I      intronic
chr9:136749228(-) A-I      intronic
chr9:136696458(-) A-I      intronic
chr9:136849238(-) A-I      intronic
chr9:136850597(-) A-I      intronic
chr9:136764702(-) A-I      intronic
chr9:136765275(-) A-I      intronic
chr9:136813050(-) A-I      intronic
chr9:136770902(-) A-I      intronic
chr9:136850480(-) A-I      intronic
chr9:136789589(-) A-I      intronic
chr9:136764636(-) A-I      intronic
chr9:136813116(-) A-I      intronic
chr9:136806358(-) A-I      intronic
chr9:136849191(-) A-I      intronic
chr9:136765021(-) A-I      intronic
chr9:136812974(-) A-I      intronic
chr9:136734382(-) A-I      intronic
chr9:136734556(-) A-I      intronic
chr9:136849857(-) A-I      intronic
chr9:136813180(-) A-I      intronic
chr9:136697908(-) A-I      intronic
chr9:136813159(-) A-I      intronic
chr9:136849265(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED VAV2
chr9:136849231(-) A-G intron -    22484847
chr9:136849232(-) A-G intron -    22484847
chr9:136850568(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VAV2
chr9:136627878-136627879(-) m6A 3'UTR       25456834
chr9:136628531-136628532(-) m6A 3'UTR       27773536
chr9:136628577-136628578(-) m6A 3'UTR       27371828//27773536
chr9:136628680-136628681(-) m6A 3'UTR       25456834//27371828//27773536
chr9:136628699-136628700(-) m6A 3'UTR       24284625//25456834//27371828//27773536
chr9:136628747-136628748(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536
chr9:136628779-136628780(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22608085
chr9:136628791-136628792(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22608085
chr9:136628822-136628823(-) m6A 3'UTR       24284625//25456834//24981863//27371828//27773536//22608085
chr9:136628960-136628961(-) m6A 3'UTR       24981863//27773535
chr9:136629024-136629025(-) m6A 3'UTR       24981863//27773535
chr9:136629030-136629031(-) m6A 3'UTR       24981863//27773535
chr9:136629163-136629164(-) m6A 3'UTR       24981863
chr9:136629168-136629169(-) m6A 3'UTR       24981863
chr9:136633574-136633575(-) m6A CDS       24981863
chr9:136633597-136633598(-) m6A CDS       -
chr9:136635567-136635568(-) m6A CDS       27773535
chr9:136637126-136637127(-) m6A CDS       27773535
chr9:136640111-136640112(-) m6A CDS       -
chr9:136649472-136649473(-) m6A CDS       27773535
chr9:136649522-136649523(-) m6A CDS       27773535
chr9:136649534-136649535(-) m6A CDS       27773535
chr9:136650943-136650944(-) m6A CDS       27773535
chr9:136656948-136656949(-) m6A CDS       27773535
chr9:136656956-136656957(-) m6A CDS       27773535
chr9:136662883-136662884(-) m6A CDS       -
chr9:136672407-136672408(-) m6A CDS       27773535//27371828//22575960
chr9:136674171-136674172(-) m6A CDS       24981863//27773535//27371828//22575960
chr9:136674202-136674203(-) m6A CDS       24209618//24981863//27773535//27371828//22575960
chr9:136674228-136674229(-) m6A CDS       24209618//24981863//27773535//27371828//22575960
chr9:136677266-136677267(-) m6A CDS       24209618//24981863//27773535//27371828//22575960
chr9:136677317-136677318(-) m6A CDS       24209618//27773535//22575960
chr9:136699442-136699443(-) m6A CDS       27773535//22575960
chr9:136857224-136857225(-) m6A CDS//exon       27773536
chr9:136857524-136857525(-) m6A 5'UTR       25456834//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
VAV2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: VAV2

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence miRNA array
Prediction-Evidence miRanda//PicTar//RNAHybrid//Targetscan
Support Database VIRmiRNA

References:


PMID 23418453 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Huh7.5 cells Interactor2 expression None
Description Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.

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