Detail Information

Basic Information:


  VIRBase ID:  

HHID00019193

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           PDGFRB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p PDGFRB
miRBase
Accession/Entrez ID		 MIMAT0000245 5159
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CD140B//IBGC4//IMF1//JTK12//KOGS//PDGFR//PDGFR-1//PDGFR1//PENTT

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PDGFRB
chr5:149531673(-) A-I      intronic
chr5:149531664(-) A-I      intronic
chr5:149531663(-) A-I      intronic
chr5:149525352(-) A-I      intronic
chr5:149525377(-) A-I      intronic
chr5:149531547(-) A-I      intronic
chr5:149531649(-) A-I      intronic
chr5:149531266(-) A-I      intronic
chr5:149531268(-) A-I      intronic
chr5:149531563(-) A-I      intronic
chr5:149526260(-) A-I      intronic
chr5:149525378(-) A-I      intronic
chr5:149526224(-) A-I      intronic
chr5:149531595(-) A-I      intronic
chr5:149531599(-) A-I      intronic
chr5:149525460(-) A-I      intronic
chr5:149525381(-) A-I      intronic
chr5:149525427(-) A-I      intronic
chr5:149531567(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PDGFRB
chr5:149531599(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PDGFRB
chr5:149493522-149493523(-) m6A 3'UTR//exon       24284625
chr5:149493780-149493781(-) m6A 3'UTR//intron       24284625
chr5:149493910-149493911(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149493930-149493931(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149493939-149493940(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149493948-149493949(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149494019-149494020(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149494069-149494070(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149494077-149494078(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149494087-149494088(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863
chr5:149494158-149494159(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535
chr5:149494196-149494197(-) m6A 3'UTR//intron       24284625//24209618//25456834//27773535
chr5:149494204-149494205(-) m6A 3'UTR//intron       24284625//24209618//25456834//27773535
chr5:149494267-149494268(-) m6A 3'UTR//intron       24284625//24209618//25456834//27773535
chr5:149494362-149494363(-) m6A 3'UTR//exon       24284625//24209618//24981863
chr5:149494438-149494439(-) m6A 3'UTR//exon       24284625//24209618//24981863
chr5:149494679-149494680(-) m6A 3'UTR       24284625
chr5:149495070-149495071(-) m6A 3'UTR       24284625//24981863
chr5:149495142-149495143(-) m6A 3'UTR       24284625//24981863
chr5:149495171-149495172(-) m6A 3'UTR       24284625
chr5:149495385-149495386(-) m6A 3'UTR//CDS       24284625
chr5:149495439-149495440(-) m6A 3'UTR//CDS       24284625
chr5:149497230-149497231(-) m6A 3'UTR//CDS       24284625
chr5:149514356-149514357(-) m6A CDS       24981863
chr5:149514369-149514370(-) m6A CDS       24981863
chr5:149514389-149514390(-) m6A CDS       24981863
chr5:149535025-149535026(-) m6A 5'UTR//exon       -
chr5:149535067-149535068(-) m6A 5'UTR//exon       -
chr5:149535247-149535248(-) m6A 5'UTR//exon       -
chr5:149535255-149535256(-) m6A 5'UTR//exon       -
chr5:149535374-149535375(-) m6A 5'UTR//exon       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
PDGFRB
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: PDGFRB

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence miRNA array
Prediction-Evidence miRanda//PicTar//RNAHybrid//Targetscan
Support Database VIRmiRNA

References:


PMID 23418453 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Huh7.5 cells Interactor2 expression None
Description Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.

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