Detail Information

Basic Information:


  VIRBase ID:  

HHID00019188

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           KRAS:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p KRAS
miRBase
Accession/Entrez ID		 MIMAT0000245 3845
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 'C-K-RAS//C-K-RAS//c-Ki-ras//c-Ki-ras2//CFC2//K-Ras//K-Ras 2//K-RAS2A//K-RAS2B//K-RAS4A//K-RAS4B//KI-RAS//KRAS1//KRAS2//NS//NS3//OES//RALD//RASK2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KRAS
chr12:25364397(-) A-I      intronic
chr12:25384258(-) A-I      intronic
chr12:25384200(-) A-I      intronic
chr12:25372046(-) A-I      intronic
chr12:25384290(-) A-I      intronic
chr12:25374360(-) A-I      intronic
chr12:25384190(-) A-I      intronic
chr12:25374361(-) A-I      intronic
chr12:25384240(-) A-I      intronic
chr12:25374327(-) A-I      intronic
chr12:25372011(-) A-I      intronic
chr12:25374275(-) A-I      intronic
chr12:25384234(-) A-I      intronic
chr12:25372052(-) A-I      intronic
chr12:25372051(-) A-I      intronic
chr12:25372048(-) A-I      intronic
chr12:25372037(-) A-I      intronic
chr12:25372042(-) A-I      intronic
chr12:25372043(-) A-I      intronic
chr12:25383424(-) A-I      intronic
chr12:25383462(-) A-I      intronic
chr12:25374331(-) A-I      intronic
chr12:25383413(-) A-I      intronic
chr12:25383360(-) A-I      intronic
chr12:25382978(-) A-I      intronic
chr12:25382867(-) A-I      intronic
chr12:25382827(-) A-I      intronic
chr12:25381858(-) A-I      intronic
chr12:25374975(-) A-I      intronic
chr12:25384132(-) A-I      intronic
chr12:25401045(-) A-I      intronic
chr12:25401203(-) A-I      intronic
chr12:25365438(-) A-I      intronic
chr12:25374971(-) A-I      intronic
chr12:25383515(-) A-I      intronic
chr12:25370746(-) A-I      intronic
chr12:25381830(-) A-I      intronic
chr12:25372001(-) A-I      intronic
chr12:25374258(-) A-I      intronic
chr12:25383499(-) A-I      intronic
chr12:25374264(-) A-I      intronic
chr12:25381750(-) A-I      intronic
chr12:25382964(-) A-I      intronic
chr12:25382915(-) A-I      intronic
chr12:25374961(-) A-I      intronic
chr12:25370728(-) A-I      intronic
chr12:25383418(-) A-I      intronic
chr12:25382779(-) A-I      intronic
chr12:25383510(-) A-I      intronic
chr12:25402183(-) A-I      intronic
chr12:25369459(-) A-I      intronic
chr12:25399380(-) A-I      intronic
chr12:25374252(-) A-I      intronic
chr12:25370742(-) A-I      intronic
chr12:25365781(-) A-I      intronic
chr12:25381735(-) A-I      intronic
chr12:25371969(-) A-I      intronic
chr12:25370776(-) A-I      intronic
chr12:25374400(-) A-I      intronic
chr12:25374342(-) A-I      intronic
chr12:25383306(-) A-I      intronic
chr12:25374234(-) A-I      intronic
chr12:25383493(-) A-I      intronic
chr12:25383365(-) A-I      intronic
chr12:25369311(-) A-I      intronic
chr12:25374263(-) A-I      intronic
chr12:25384160(-) A-I      intronic
chr12:25365830(-) A-I      intronic
chr12:25369468(-) A-I      intronic
chr12:25365829(-) A-I      intronic
chr12:25374304(-) A-I      intronic
chr12:25364479(-) A-I      intronic
chr12:25374395(-) A-I      intronic
chr12:25365845(-) A-I      intronic
chr12:25365441(-) A-I      intronic
chr12:25365803(-) A-I      intronic
chr12:25365735(-) A-I      intronic
chr12:25382886(-) A-I      intronic
chr12:25384213(-) A-I      intronic
chr12:25382928(-) A-I      intronic
chr12:25384174(-) A-I      intronic
chr12:25374256(-) A-I      intronic
chr12:25374423(-) A-I      intronic
chr12:25383480(-) A-I      intronic
chr12:25384289(-) A-I      intronic
chr12:25365741(-) A-I      intronic
chr12:25381825(-) A-I      intronic
chr12:25373896(-) A-I      intronic
chr12:25374290(-) A-I      intronic
chr12:25365415(-) A-I      intronic
chr12:25365746(-) A-I      intronic
chr12:25370828(-) A-I      intronic
chr12:25382935(-) A-I      intronic
chr12:25383479(-) A-I      intronic
chr12:25374935(-) A-I      intronic
chr12:25374371(-) A-I      intronic
chr12:25369347(-) A-I      intronic
chr12:25384184(-) A-I      intronic
chr12:25374340(-) A-I      intronic
chr12:25374895(-) A-I      intronic
chr12:25401160(-) A-I      intronic
chr12:25384248(-) A-I      intronic
chr12:25381776(-) A-I      intronic
chr12:25374372(-) A-I      intronic
chr12:25364422(-) A-I      intronic
chr12:25401321(-) A-I      intronic
chr12:25383557(-) A-I      intronic
chr12:25383559(-) A-I      intronic
chr12:25374295(-) A-I      intronic
chr12:25372145(-) A-I      intronic
chr12:25401161(-) A-I      intronic
chr12:25382940(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KRAS
chr12:25365741(-) A-I intron -    21960545   //22327324
chr12:25365781(-) A-I intron -    21960545   //22327324
chr12:25365415(-) A-I intron -    21960545
chr12:25365416(-) A-I intron -    21960545
chr12:25365829(-) A-I intron -    21960545
chr12:25365830(-) A-I intron -    21960545
chr12:25365833(-) A-I intron -    21960545
chr12:25369307(-) A-I intron -    21960545
chr12:25369341(-) A-I intron -    21960545
chr12:25369347(-) A-I intron -    21960545
chr12:25370623(-) A-I intron -    21960545
chr12:25370728(-) A-I intron -    21960545
chr12:25370746(-) A-I intron -    21960545
chr12:25370776(-) A-I intron -    21960545
chr12:25370828(-) A-I intron -    21960545
chr12:25382901(-) A-I intron -    21960545
chr12:25383306(-) A-I intron -    21960545
chr12:25383424(-) A-I intron -    21960545
chr12:25383557(-) A-I intron -    21960545
chr12:25360448(-) G-T exon 3'UTR    22484847
chr12:25360449(-) G-T exon 3'UTR    22484847
chr12:25365741(-) A-G intron -    22484847
chr12:25365781(-) A-G intron -    22484847
chr12:25365958(-) T-C intron -    22484847
chr12:25374244(-) T-C intron -    22484847
chr12:25382928(-) A-G intron -    22484847
chr12:25382935(-) A-G intron -    22484847
chr12:25383480(-) A-G intron -    22484847
chr12:25369303(-) T-C intron -    22484847
chr12:25370828(-) A-G intron -    22484847
chr12:25372145(-) A-G intron -    22484847
chr12:25374395(-) A-G intron -    22484847
chr12:25374400(-) A-G intron -    22484847
chr12:25374423(-) A-G intron -    22484847
chr12:25374895(-) A-G intron -    22484847
chr12:25382780(-) T-C intron -    22484847
chr12:25383365(-) A-G intron -    22484847
chr12:25383479(-) A-G intron -    22484847
chr12:25383493(-) A-G intron -    22484847
chr12:25383510(-) A-G intron -    22484847
chr12:25384160(-) A-G intron -    22484847
chr12:25384184(-) A-G intron -    22484847
chr12:25401160(-) A-G intron -    22484847
chr12:25401161(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KRAS
chr12:25362748-25362749(-) m6A 3'UTR//CDS       24981863//27773535
chr12:25362800-25362801(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr12:25368415-25368416(-) m6A CDS//intron       27773535//27371828
chr12:25378550-25378551(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378555-25378556(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378567-25378568(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378602-25378603(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378613-25378614(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378620-25378621(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378627-25378628(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378683-25378684(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378703-25378704(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25380237-25380238(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380251-25380252(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380309-25380310(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25387487-25387488(-) m6A 3'UTR//intron       27773535
chr12:25387524-25387525(-) m6A 3'UTR//intron       27773535
chr12:25398303-25398304(-) m6A CDS       24209618//27371828
chr12:25403761-25403762(-) m6A 5'UTR       24209618//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
KRAS
Chromatin K562 cells     -
Exosome Serum     -
Mitochondrion HDF cells     16178658
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: KRAS

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence miRNA array
Prediction-Evidence miRanda//PicTar//RNAHybrid//Targetscan
Support Database VIRmiRNA

References:


PMID 23418453 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Huh7.5 cells Interactor2 expression None
Description Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.

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