Basic Information:

  VIRBase ID:  

HHID00019187

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          ITGB3:  NM_000212     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	ITGB3
miRBase Accession/Entrez ID	MIMAT0000245	3690
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BDPLT16//BDPLT2//CD61//GP3A//GPIIIa//GT

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITGB3	chr17:45386543(+) A-I      intronic chr17:45386555(+) A-I      intronic chr17:45386570(+) A-I      intronic chr17:45386602(+) A-I      intronic chr17:45386489(+) A-I      intronic chr17:45387076(+) A-I      intronic chr17:45387079(+) A-I      intronic chr17:45387080(+) A-I      intronic chr17:45387084(+) A-I      intronic chr17:45385373(+) A-I      intronic chr17:45385370(+) A-I      intronic chr17:45386604(+) A-I      intronic chr17:45332605(+) A-I      intronic chr17:45385356(+) A-I      intronic chr17:45332554(+) A-I      intronic chr17:45334824(+) A-I      intronic chr17:45387102(+) A-I      intronic chr17:45387103(+) A-I      intronic chr17:45387108(+) A-I      intronic chr17:45387109(+) A-I      intronic chr17:45387110(+) A-I      intronic chr17:45387111(+) A-I      intronic chr17:45387114(+) A-I      intronic chr17:45336056(+) A-I      intronic chr17:45385312(+) A-I      intronic chr17:45385333(+) A-I      intronic chr17:45385336(+) A-I      intronic chr17:45385346(+) A-I      intronic chr17:45386539(+) A-I      intronic chr17:45385385(+) A-I      intronic chr17:45385381(+) A-I      intronic chr17:45385379(+) A-I      intronic chr17:45385374(+) A-I      intronic chr17:45385411(+) A-I      intronic chr17:45385417(+) A-I      intronic chr17:45387073(+) A-I      intronic chr17:45387074(+) A-I      intronic chr17:45387157(+) A-I      intronic chr17:45387241(+) A-I      intronic chr17:45387242(+) A-I      intronic chr17:45385453(+) A-I      intronic chr17:45385457(+) A-I      intronic chr17:45386481(+) A-I      intronic chr17:45386513(+) A-I      intronic chr17:45386526(+) A-I      intronic chr17:45386547(+) A-I      intronic chr17:45386553(+) A-I      intronic chr17:45387005(+) A-I      intronic chr17:45387031(+) A-I      intronic chr17:45387045(+) A-I      intronic chr17:45387245(+) A-I      intronic chr17:45387050(+) A-I      intronic chr17:45385276(+) A-I      intronic chr17:45387246(+) A-I      intronic chr17:45332579(+) A-I      intronic chr17:45332592(+) A-I      intronic chr17:45332927(+) A-I      intronic chr17:45333558(+) A-I      intronic chr17:45333603(+) A-I      intronic chr17:45333661(+) A-I      intronic chr17:45336043(+) A-I      intronic chr17:45336047(+) A-I      intronic chr17:45336048(+) A-I      intronic chr17:45336083(+) A-I      intronic chr17:45337106(+) A-I      intronic chr17:45337107(+) A-I      intronic chr17:45366756(+) A-I      intronic chr17:45366761(+) A-I      intronic chr17:45374911(+) A-I      intronic chr17:45364995(+) A-I      intronic chr17:45385277(+) A-I      intronic chr17:45385299(+) A-I      intronic chr17:45385382(+) A-I      intronic chr17:45333554(+) A-I      intronic chr17:45374962(+) A-I      intronic chr17:45387004(+) A-I      intronic chr17:45336071(+) A-I      intronic chr17:45335992(+) A-I      intronic chr17:45333594(+) A-I      intronic chr17:45375056(+) A-I      intronic chr17:45387089(+) A-I      intronic chr17:45386514(+) A-I      intronic chr17:45333582(+) A-I      intronic chr17:45333576(+) A-I      intronic chr17:45333060(+) A-I      intronic chr17:45335994(+) A-I      intronic chr17:45375197(+) A-I      intronic chr17:45337010(+) A-I      intronic chr17:45333650(+) A-I      intronic chr17:45333078(+) A-I      intronic chr17:45387206(+) A-I      intronic chr17:45333048(+) A-I      intronic chr17:45333568(+) A-I      intronic chr17:45385949(+) A-I      intronic chr17:45386624(+) A-I      intronic chr17:45332953(+) A-I      intronic chr17:45371012(+) A-I      intronic chr17:45332836(+) A-I      intronic chr17:45385412(+) A-I      intronic chr17:45381522(+) A-I      intronic chr17:45332617(+) A-I      intronic chr17:45332968(+) A-I      intronic chr17:45365076(+) A-I      intronic chr17:45336006(+) A-I      intronic chr17:45385969(+) A-I      intronic chr17:45375228(+) A-I      intronic chr17:45387170(+) A-I      intronic chr17:45387150(+) A-I      intronic chr17:45374766(+) A-I      intronic chr17:45333047(+) A-I      intronic chr17:45386608(+) A-I      intronic chr17:45385893(+) A-I      intronic chr17:45333073(+) A-I      intronic chr17:45336018(+) A-I      intronic chr17:45386679(+) A-I      intronic chr17:45387207(+) A-I      intronic chr17:45332619(+) A-I      intronic chr17:45375218(+) A-I      intronic chr17:45333577(+) A-I      intronic chr17:45385291(+) A-I      intronic chr17:45375183(+) A-I      intronic chr17:45365075(+) A-I      intronic chr17:45332971(+) A-I      intronic chr17:45375187(+) A-I      intronic chr17:45386654(+) A-I      intronic chr17:45332607(+) A-I      intronic chr17:45386666(+) A-I      intronic chr17:45333606(+) A-I      intronic chr17:45387140(+) A-I      intronic chr17:45332943(+) A-I      intronic chr17:45337101(+) A-I      intronic chr17:45376416(+) A-I      intronic chr17:45333622(+) A-I      intronic chr17:45332997(+) A-I      intronic chr17:45332988(+) A-I      intronic chr17:45336011(+) A-I      intronic chr17:45386518(+) A-I      intronic chr17:45387181(+) A-I      intronic chr17:45386638(+) A-I      intronic chr17:45332528(+) A-I      intronic chr17:45385435(+) A-I      intronic chr17:45387146(+) A-I      intronic chr17:45332857(+) A-I      intronic chr17:45385323(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITGB3	chr17:45386638(+) A-I intron -    21960545 chr17:45386666(+) A-I intron -    21960545 chr17:45387089(+) A-I intron -    21960545 chr17:45387206(+) A-I intron -    21960545 chr17:45336018(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITGB3	chr17:45369589-45369590(+) m6A CDS       24209618//24981863 chr17:45369647-45369648(+) m6A CDS       24209618//24981863 chr17:45369681-45369682(+) m6A CDS       24209618//24981863 chr17:45369751-45369752(+) m6A CDS       24209618//24981863 chr17:45376697-45376698(+) m6A CDS       - chr17:45376720-45376721(+) m6A CDS       - chr17:45384927-45384928(+) m6A CDS       - chr17:45384998-45384999(+) m6A CDS       - chr17:45387646-45387647(+) m6A 3'UTR       24981863 chr17:45389034-45389035(+) m6A 3'UTR       24981863 chr17:45389043-45389044(+) m6A 3'UTR       24981863 chr17:45389063-45389064(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ITGB3	Cytosol HeLa-S3 cells     - Exosome Plasma     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: ITGB3

Evidence Support:

Strong-Evidence	qRT-PCR
Weak-Evidence	miRNA array
Prediction-Evidence	miRanda//PicTar//RNAHybrid//Targetscan
Support Database	VIRmiRNA

References:

PMID	23418453	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	Huh7.5 cells	Interactor2 expression	None
Description	Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.