Detail Information

Basic Information:


  VIRBase ID:  

HHID00019179

  Virus:  

Hepacivirus C (Hepatitis C virus genotype 2,HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           ACTN1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p ACTN1
miRBase
Accession/Entrez ID		 MIMAT0000245 87
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BDPLT15

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ACTN1
chr14:69421105(-) A-I      intronic
chr14:69421121(-) A-I      intronic
chr14:69421113(-) A-I      intronic
chr14:69421112(-) A-I      intronic
chr14:69416778(-) A-I      intronic
chr14:69400442(-) A-I      intronic
chr14:69400469(-) A-I      intronic
chr14:69416828(-) A-I      intronic
chr14:69416899(-) A-I      intronic
chr14:69416959(-) A-I      intronic
chr14:69400434(-) A-I      intronic
chr14:69400572(-) A-I      intronic
chr14:69401836(-) A-I      intronic
chr14:69417459(-) A-I      intronic
chr14:69417529(-) A-I      intronic
chr14:69379188(-) A-I      intronic
chr14:69384603(-) A-I      intronic
chr14:69350426(-) A-I      intronic
chr14:69379156(-) A-I      intronic
chr14:69381473(-) A-I      intronic
chr14:69384591(-) A-I      intronic
chr14:69400454(-) A-I      intronic
chr14:69400455(-) A-I      intronic
chr14:69417528(-) A-I      intronic
chr14:69343626(-) A-I      intronic
chr14:69350435(-) A-I      intronic
chr14:69421277(-) A-I      intronic
chr14:69415232(-) A-I      intronic
chr14:69400562(-) A-I      intronic
chr14:69417417(-) A-I      intronic
chr14:69364770(-) A-I      intronic
chr14:69350271(-) A-I      intronic
chr14:69402027(-) A-I      intronic
chr14:69379380(-) A-I      intronic
chr14:69415248(-) A-I      intronic
chr14:69363838(-) A-I      intronic
chr14:69400481(-) A-I      intronic
chr14:69355526(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ACTN1
chr14:69353342(-) C-G intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACTN1
chr14:69341320-69341321(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr14:69341362-69341363(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr14:69341370-69341371(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr14:69341621-69341622(-) m6A CDS//exon       24284625//24981863//26404942//22575960
chr14:69341732-69341733(-) m6A CDS//exon       24284625//26404942//27773535
chr14:69341768-69341769(-) m6A CDS//intron       24284625//27773535
chr14:69343802-69343803(-) m6A CDS//exon       26404942//27773535//22575960
chr14:69343838-69343839(-) m6A CDS//exon       26404942//27773535//22575960
chr14:69343860-69343861(-) m6A CDS//exon       26404942//27773535//22575960
chr14:69343919-69343920(-) m6A CDS//exon       26404942//27773535//27773536//22575960
chr14:69345356-69345357(-) m6A exon//intron       27773535
chr14:69345419-69345420(-) m6A exon//intron       27773535
chr14:69346760-69346761(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828
chr14:69346779-69346780(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828
chr14:69347642-69347643(-) Cm CDS//exon       -
chr14:69347662-69347663(-) m6A CDS//exon//intron       24284625//26404942//27773535//22575960
chr14:69347672-69347673(-) m6A CDS//exon//intron       24284625//26404942//27773535//22575960
chr14:69347812-69347813(-) m6A exon//intron       22575960
chr14:69349185-69349186(-) m6A CDS//exon//intron       24981863//22575960
chr14:69349283-69349284(-) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//27371828//22575960
chr14:69349593-69349594(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828//22575960
chr14:69349666-69349667(-) m6A CDS//exon//intron       24284625//24981863//26404942//27773535//27371828//22575960
chr14:69349769-69349770(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828
chr14:69350009-69350010(-) m6A exon//intron       24284625//24981863//27773535//27371828
chr14:69350918-69350919(-) m6A CDS//exon       26404942//22575960
chr14:69350927-69350928(-) m6A CDS//exon       26404942//22575960
chr14:69351003-69351004(-) m6A CDS//exon       26404942//27371828//22575960
chr14:69351013-69351014(-) m6A CDS//exon       26404942//27371828//22575960
chr14:69351021-69351022(-) m6A CDS//exon       26404942//27371828//22575960
chr14:69351534-69351535(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960
chr14:69351591-69351592(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//27773536//22575960
chr14:69352180-69352181(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//27773536//22575960
chr14:69352256-69352257(-) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr14:69352264-69352265(-) m6A CDS//exon       24284625//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr14:69352345-69352346(-) m6A exon//intron       24284625//25456834//27773535//27371828//27773536//22575960
chr14:69354593-69354594(-) m6A exon//intron       24209618//24981863//27773535//27371828
chr14:69354618-69354619(-) m6A exon//intron       24209618//24981863//27773535//27371828
chr14:69354647-69354648(-) m6A exon//intron       24209618//24981863//27773535//27371828
chr14:69354661-69354662(-) m6A exon//intron       24209618//24981863//27773535//27371828
chr14:69354720-69354721(-) m6A exon//intron       24209618//24981863//27773535//27371828
chr14:69354831-69354832(-) m6A exon//intron       24209618//24981863//27371828
chr14:69354921-69354922(-) m6A exon//intron       24209618//25456834//27371828
chr14:69356861-69356862(-) m6A CDS       24284625//24209618//26404942//22575960
chr14:69356911-69356912(-) m6A CDS       24284625//24209618//26404942//27371828//22575960
chr14:69356936-69356937(-) Gm CDS       -
chr14:69358828-69358829(-) m6A CDS       24284625//27371828//22575960
chr14:69358902-69358903(-) m6A CDS       24284625//26404942//27371828//22575960
chr14:69358911-69358912(-) m6A CDS       24284625//26404942//27371828//22575960
chr14:69358944-69358945(-) m6A CDS       24284625//26404942//27773535//27371828//22575960
chr14:69358959-69358960(-) m6A CDS       24284625//26404942//27773535//27371828//22575960
chr14:69360393-69360394(-) m6A CDS       26404942//27773535//27371828//22575960
chr14:69360406-69360407(-) Cm CDS       -
chr14:69360457-69360458(-) m6A CDS//exon       27773535//27371828//22575960
chr14:69369267-69369268(-) m6A CDS//exon       27371828
chr14:69371397-69371398(-) m6A CDS//exon       26404942//27371828
chr14:69376683-69376684(-) m6A CDS//exon       26404942//27371828//22575960
chr14:69376714-69376715(-) m6A CDS//exon       26404942//27371828//22575960
chr14:69376756-69376757(-) m6A CDS//exon       26404942//27773535//27371828//22575960
chr14:69378886-69378887(-) m6A CDS//exon       26404942//27773535//27371828//22575960
chr14:69378914-69378915(-) m6A CDS//exon       26404942//27773535//27371828//22575960
chr14:69387744-69387745(-) m6A CDS//exon       26404942//27773535//27371828//22575960
chr14:69392321-69392322(-) m6A 5'UTR//CDS       24284625//26404942//27773535//27371828//22575960
chr14:69392333-69392334(-) m6A 5'UTR//CDS       24284625//26404942//27773535//27371828//22575960
chr14:69392346-69392347(-) m6A 5'UTR//CDS       24284625//26404942//27773535//27371828//22575960
chr14:69414106-69414107(-) m6A 5'UTR//intron       24284625//26404942//27773535//27371828
chr14:69414129-69414130(-) m6A 5'UTR//intron       24284625//27773535//27371828
chr14:69414158-69414159(-) m6A 5'UTR//intron       24284625//27773535//27371828
chr14:69445183-69445184(-) m6A 5'UTR//intron       -
chr14:69445319-69445320(-) m6A 5'UTR//intron       -
chr14:69445696-69445697(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960
chr14:69445708-69445709(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960
chr14:69445714-69445715(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960
chr14:69445720-69445721(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960
chr14:69445748-69445749(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960
chr14:69445768-69445769(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22575960
chr14:69445794-69445795(-) m6A 5'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960
chr14:69445909-69445910(-) m6A 5'UTR       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
ACTN1
Chromatin K562 cells     -
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: ACTN1

Evidence Support:


Strong-Evidence qRT-PCR
Weak-Evidence miRNA array
Prediction-Evidence miRanda//PicTar//RNAHybrid//Targetscan
Support Database VIRmiRNA

References:


PMID 23418453 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line Huh7.5 cells Interactor2 expression None
Description Seven miRNAs (miR-30b, miR-30c, miR-130a, miR-192, miR-301, miR-324-5p, and miR-565) were down-regulated in HCV-infected Huh7.5 cells (p<0.05) and subsequently up-regulated following interferon-alpha treatment (p<0.01). The miR-30(a-d) cluster and miR-130a/301 and their putative mRNA targets were predicted to be associated with cellular pathways that involve Hepatitis C virus entry, propagation and host response to viral infection.

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