Basic Information:

  VIRBase ID:  

HHID00019091

  Virus:  

Hepacivirus C (HCV)

  Host:  

Rattus norvegicus

  Confidence Score:  

0.9526

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      rno-miR-122-5p:  MIMAT0000827          Slc7a1:  NM_013111     

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Interactor Information:

	Interactor1	Interactor2
Symbol	rno-miR-122-5p	Slc7a1
miRBase Accession/Entrez ID	MIMAT0000827	25648
Organism	Rattus norvegicus	Rattus norvegicus
Category	miRNA	mRNA
Alias	-	Atrc1//Cat-1//CAT1//EcoR

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	rno-miR-122-5p	Axon Sympathetic neurons     20584895

Interaction Network (The top 100 interactions):

Interactor1: rno-miR-122-5p
Interactor2: Slc7a1

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Northern blot//Western blot
Support Database	ViRBase

References:

PMID	17381319	Target region	3'NCR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Huh7 cells	Interactor2 expression	Downregulation
Description	CAT-1 activity is absent in the quiescent liver, but it is increased in primary or transformed hepatocytes.Incontrast, interaction of miR-122 with the 3'-noncoding region(3'NCR) of the cellularmRNA encoding the cationic amino acid transporter CAT-1 resulted in the down-regulation of CAT-1 protein abundance.