Basic Information:

  VIRBase ID:  

HHID00019088

  Virus:  

Hepacivirus C (HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-3p:  MIMAT0004551          IFNB1:  NM_002176     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-3p	IFNB1
miRBase Accession/Entrez ID	MIMAT0004551	3456
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-3p	rs1315913671 chr8:134804890    C/G rs1444509052 chr8:134804884    A/G rs1447612668 chr8:134804889    T/C rs185802410 chr8:134804886    A/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNB1	chr9:21077198-21077199(-) m6A 3'UTR       27773535 chr9:21077273-21077274(-) m6A 3'UTR       27773535 chr9:21077278-21077279(-) m6A 3'UTR       27773535 chr9:21077308-21077309(-) m6A CDS       27773535 chr9:21077328-21077329(-) m6A CDS       27773535 chr9:21077347-21077348(-) m6A CDS       27773535 chr9:21077375-21077376(-) m6A CDS       27773535 chr9:21077592-21077593(-) m6A CDS       27773535 chr9:21077611-21077612(-) m6A CDS       27773535 chr9:21077695-21077696(-) m6A CDS       27773535 chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-3p
Interactor2: IFNB1

Evidence Support:

Strong-Evidence	TaqMan qRT-PCR
Support Database	VIRmiRNA

References:

PMID	21070682	Target region	None
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	PBMCs	Interactor2 expression	None
Description	Our analysis revealed that the levels of expression of all miRNAs investigated in patients with CHC were different to those in healthy individuals. When levels of the miRNAs were measured 12 hours after the first IFN injection, increases in expression levels of IFN-induced miRNAs were observed in 25-50% of patients, depending on the type of miRNA examined.