Detail Information

Basic Information:


  VIRBase ID:  

HHID00019087

  Virus:  

Hepacivirus C (HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30c-2-3p:           IFNB1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30c-2-3p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0004550 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30c-2-3p
rs1262929323 chr6:71376964    A/G
rs1413659455 chr6:71376968    T/C
rs1421032991 chr6:71376975    C/A
rs1421032991 chr6:71376975    C/G
rs1488181071 chr6:71376967    G/T
rs747913643 chr6:71376976    C/A
rs760276048 chr6:71376974    G/C
rs775896072 chr6:71376969    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30c-2-3p
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Plasma     23663360
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30c-2-3p
Gemcitabine 60750 Drug interaction    RC00006870
Eloxatine 5310940 Drug interaction    RC00006871
5-Fluorouracil 3385 Drug interaction    RC00006869
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30c-2-3p
Cisplatin 5702198       27506865

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30c-2-3p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence TaqMan qRT-PCR
Support Database VIRmiRNA

References:


PMID 21070682 Target region None
Source VIRmiRNA Interactor1 expression None
Tissue or cell line PBMCs Interactor2 expression None
Description Our analysis revealed that the levels of expression of all miRNAs investigated in patients with CHC were different to those in healthy individuals. When levels of the miRNAs were measured 12 hours after the first IFN injection, increases in expression levels of IFN-induced miRNAs were observed in 25-50% of patients, depending on the type of miRNA examined.

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