Detail Information

Basic Information:


  VIRBase ID:  

HHID00019086

  Virus:  

Hepacivirus C (HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-758-3p:           TLR7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-758-3p TLR7
miRBase
Accession/Entrez ID		 MIMAT0003879 51284
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IMD74//TLR7-like

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-758-3p
rs1165305945 chr14:101026084    C/T
rs1432780238 chr14:101026090    A/G
rs992122694 chr14:101026080    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TLR7
chrX:12894099(+) A-I      intronic
chrX:12892292(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TLR7
chrX:12895719-12895720(+) m6A exon//intron       -
chrX:12903645-12903646(+) m6A CDS       -
chrX:12903656-12903657(+) m6A CDS       -
chrX:12903695-12903696(+) m6A CDS       -
chrX:12903723-12903724(+) m6A CDS       -
chrX:12903760-12903761(+) m6A CDS       -
chrX:12903775-12903776(+) m6A CDS       -
chrX:12903784-12903785(+) m6A CDS       -
chrX:12903823-12903824(+) m6A CDS       -
chrX:12903832-12903833(+) m6A CDS       -
chrX:12903862-12903863(+) m6A CDS       -
chrX:12903887-12903888(+) m6A CDS       -
chrX:12903892-12903893(+) m6A CDS       -
chrX:12903952-12903953(+) m6A CDS       -
chrX:12903983-12903984(+) m6A CDS       -
chrX:12904001-12904002(+) m6A CDS       -
chrX:12904036-12904037(+) m6A CDS       -
chrX:12904136-12904137(+) m6A CDS       -
chrX:12904171-12904172(+) m6A CDS       -
chrX:12904231-12904232(+) m6A CDS       -
chrX:12904313-12904314(+) m6A CDS       -
chrX:12904561-12904562(+) m6A CDS       -
chrX:12904571-12904572(+) m6A CDS       -
chrX:12904580-12904581(+) m6A CDS       -
chrX:12904597-12904598(+) m6A CDS       -
chrX:12904682-12904683(+) m6A CDS       -
chrX:12904880-12904881(+) m6A CDS       -
chrX:12904892-12904893(+) m6A CDS       -
chrX:12904974-12904975(+) m6A CDS       -
chrX:12904994-12904995(+) m6A CDS       -
chrX:12905009-12905010(+) m6A CDS       -
chrX:12905062-12905063(+) m6A CDS       -
chrX:12905115-12905116(+) m6A CDS       -
chrX:12905220-12905221(+) m6A CDS       -
chrX:12905269-12905270(+) m6A CDS       -
chrX:12905327-12905328(+) m6A CDS       -
chrX:12905395-12905396(+) m6A CDS       -
chrX:12905407-12905408(+) m6A CDS       -
chrX:12905426-12905427(+) m6A CDS       -
chrX:12905469-12905470(+) m6A CDS       -
chrX:12905493-12905494(+) m6A CDS       -
chrX:12905593-12905594(+) m6A CDS       -
chrX:12905708-12905709(+) m6A CDS       -
chrX:12905725-12905726(+) m6A CDS       -
chrX:12905733-12905734(+) m6A CDS       -
chrX:12905740-12905741(+) m6A CDS       -
chrX:12905919-12905920(+) m6A CDS       -
chrX:12906289-12906290(+) m6A CDS       -
chrX:12906328-12906329(+) m6A CDS       -
chrX:12906371-12906372(+) m6A CDS       -
chrX:12906379-12906380(+) m6A CDS       -
chrX:12906392-12906393(+) m6A CDS       -
chrX:12906421-12906422(+) m6A CDS       -
chrX:12906451-12906452(+) m6A CDS       -
chrX:12906483-12906484(+) m6A CDS       -
chrX:12906502-12906503(+) m6A CDS       -
chrX:12906516-12906517(+) m6A CDS       -
chrX:12907879-12907880(+) m6A 3'UTR       -
chrX:12907958-12907959(+) m6A 3'UTR       -
chrX:12907971-12907972(+) m6A 3'UTR       -
chrX:12908075-12908076(+) m6A 3'UTR       -
chrX:12908089-12908090(+) m6A 3'UTR       -
chrX:12908119-12908120(+) m6A 3'UTR       -
chrX:12908141-12908142(+) m6A 3'UTR       -
chrX:12908153-12908154(+) m6A 3'UTR       -
chrX:12908159-12908160(+) m6A 3'UTR       -
chrX:12908218-12908219(+) m6A 3'UTR       -
chrX:12908283-12908284(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-758-3p
Exosome Plasma     23663360
Exosome Endothelial cells     -
Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
TLR7
Exosome Blood     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-758-3p
8-Aminoadenosine 96851 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Berberine iodide 72350 Drug sensitive
1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant
3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive
2-Azaadenine 5480214 Drug resistant
2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive
2-Methylolivacinium acetate 5458752 Drug sensitive
Xestin A 5352066 Drug resistant
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
6-Bromosangivamycin 470030 Drug resistant
Musennin 441933 Drug sensitive
Isobrucein A 441802 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Elliptinium acetate 42722 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive
1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant
Haloprogin 3561 Drug resistant
Maxima isoflavone D 343081 Drug sensitive
Ellipticine 3213 Drug sensitive
8-Trichloromethyldihydroberberine 320713 Drug sensitive
2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive
4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant
Sarcoviolin 24202820 Drug sensitive
Kinetin riboside 20345 Drug resistant
(R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant
(1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant
Formycin b 135449281 Drug resistant
3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant
Unii-9JU14BJ5QG 109374088 Drug sensitive
1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant
inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant
1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive
2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive
2-methylellpticinium - Drug sensitive
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
protein: pahiv4 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-758-3p
10-Hydroxycamptothecin 97226 Drug interaction    RC00006643
Cholesterol 5997 Drug interaction    RC00006640
Diethylstilbestrol 448537 Drug interaction    RC00006644
Etoposide 36462 Drug interaction    RC00006642
5-Fluorouracil 3385 Drug interaction    RC00006639
Doxorubicin 31703 Drug interaction    RC00006641
Verapamil 2520 Drug interaction    RC00006638

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-758-3p
Interactor2: TLR7

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence miRanda//PicTar
Support Database ViRBase

References:


PMID 25008898 Target region 3'UTR
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line QSG-7701 cells Interactor2 expression Downregulation
Description In conclusion, our results highlight the upregulation of miR-758 expression by HCV as a novel mechanism contributing to downregulation of TLR3 and TLR7 in patients with HCV infection.

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