Basic Information:

  VIRBase ID:  

HHID00019085

  Virus:  

Hepacivirus C (HCV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-758-3p:  MIMAT0003879          TLR3:  NM_003265     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-758-3p	TLR3
miRBase Accession/Entrez ID	MIMAT0003879	7098
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD283//IIAE2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-758-3p	rs1165305945 chr14:101026084    C/T rs1432780238 chr14:101026090    A/G rs992122694 chr14:101026080    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TLR3	chr4:187001863(+) A-I      intronic chr4:187003336(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TLR3	chr4:186990367-186990368(+) m6A 5'UTR       24981863 chr4:186997778-186997779(+) m6A CDS       24981863 chr4:187003525-187003526(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003579-187003580(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003649-187003650(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003659-187003660(+) m6A 5'UTR//CDS//exon       24981863 chr4:187003978-187003979(+) m6A CDS//exon       24981863 chr4:187004022-187004023(+) m6A CDS//exon       24284625//24981863 chr4:187004037-187004038(+) m6A CDS//exon       24284625//24981863 chr4:187004177-187004178(+) m6A CDS//exon       24209618//24981863 chr4:187004260-187004261(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004635-187004636(+) m6A CDS//exon       24981863 chr4:187004686-187004687(+) m6A CDS//exon       24981863 chr4:187004746-187004747(+) m6A CDS//exon       24981863 chr4:187004829-187004830(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004906-187004907(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004932-187004933(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187004948-187004949(+) m6A CDS//exon       24284625//24209618//24981863 chr4:187005082-187005083(+) m6A CDS//exon       24284625//24981863 chr4:187005090-187005091(+) m6A CDS//exon       24284625//24981863 chr4:187005095-187005096(+) m6A CDS//exon       24284625//24981863 chr4:187005155-187005156(+) m6A CDS//exon       24284625//24981863 chr4:187005181-187005182(+) m6A CDS//exon       24284625//25456834//24981863 chr4:187005214-187005215(+) m6A CDS//exon       25456834//24981863 chr4:187005236-187005237(+) m6A CDS//exon       25456834//24981863 chr4:187005310-187005311(+) m6A CDS//exon       24981863 chr4:187005888-187005889(+) m6A CDS//exon       24981863 chr4:187005893-187005894(+) m6A CDS//exon       24981863 chr4:187005944-187005945(+) m6A CDS//exon       24981863 chr4:187006013-187006014(+) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-758-3p	Exosome Plasma     23663360 Exosome Endothelial cells     - Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     -
	TLR3	Exosome Blood     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-758-3p	8-Aminoadenosine 96851 Drug resistant 1,9-Pyrazoloanthrone 8515 Drug resistant Berberine iodide 72350 Drug sensitive 1,3,5-Triacryloylhexahydro-1,3,5-triazine 70397 Drug resistant 3-[[4-[[2-(Methoxycarbonylamino)-3H-benzimidazol-5-yl]oxy]phenyl]carbamoylamino]benzoic acid;hydrochloride 57399799 Drug sensitive 2-Azaadenine 5480214 Drug resistant 2-(1,3-Benzodioxol-5-yl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 5466137 Drug sensitive 2-Methylolivacinium acetate 5458752 Drug sensitive Xestin A 5352066 Drug resistant 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive 6-Bromosangivamycin 470030 Drug resistant Musennin 441933 Drug sensitive Isobrucein A 441802 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive Elliptinium acetate 42722 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 2-N-Methyl-6-thiaellipticinum iodide 367888 Drug sensitive 1,1-Dioxido-1,5-benzothiazepin-4-yl methyl ether 358940 Drug resistant Haloprogin 3561 Drug resistant Maxima isoflavone D 343081 Drug sensitive Ellipticine 3213 Drug sensitive 8-Trichloromethyldihydroberberine 320713 Drug sensitive 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium acetate 3086131 Drug sensitive 4,6-Diamino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile 300567 Drug resistant Sarcoviolin 24202820 Drug sensitive Kinetin riboside 20345 Drug resistant (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant (1S,3R,5R,9R,10R)-5-Ethenyl-2,3,9,10-tetrahydroxy-5,11,11-trimethyl-16-oxatetracyclo[7.5.2.01,10.02,7]hexadec-6-en-8-one 139587002 Drug resistant Formycin b 135449281 Drug resistant 3-Bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5H)-furanone 11413833 Drug resistant Unii-9JU14BJ5QG 109374088 Drug sensitive 1,6:2,3-dianhydro-4-o-benzyl-.beta.-d-mannopyranose - Drug resistant inosine, 6-thio-, 2',3',5'-tripentanoate - Drug resistant 1-[(2-cyclohexymethoxy)methyl]-5-ethyl-6-iodouracil - Drug resistant E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive 2-(4-hydroxy-benzylidene)-2-(2-pyridyl)acetonitrile - Drug sensitive 2-methylellpticinium - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive protein: pahiv4 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-758-3p	10-Hydroxycamptothecin 97226 Drug interaction    RC00006643 Cholesterol 5997 Drug interaction    RC00006640 Diethylstilbestrol 448537 Drug interaction    RC00006644 Etoposide 36462 Drug interaction    RC00006642 5-Fluorouracil 3385 Drug interaction    RC00006639 Doxorubicin 31703 Drug interaction    RC00006641 Verapamil 2520 Drug interaction    RC00006638

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-758-3p
Interactor2: TLR3

Evidence Support:

Strong-Evidence	Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence	miRanda//PicTar
Support Database	ViRBase

References:

PMID	25008898	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	QSG-7701 cells	Interactor2 expression	Downregulation
Description	In conclusion, our results highlight the upregulation of miR-758 expression by HCV as a novel mechanism contributing to downregulation of TLR3 and TLR7 in patients with HCV infection.