Basic Information:

  VIRBase ID:  

HHID00019053

  Virus:  

Dengue virus (Dengue virus 2,DEN-2)

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30e-3p:  MIMAT0000693          IFITM1:  NM_003641     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30e-3p	IFITM1
miRBase Accession/Entrez ID	MIMAT0000693	8519
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	9-27//CD225//DSPA2a//IFI17//LEU13

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30e-3p	rs1184629069 chr1:40754434    C/T rs1217267713 chr1:40754424    A/C rs1485494658 chr1:40754429    T/G rs538913221 chr1:40754422    G/A rs756374506 chr1:40754425    T/C rs767610978 chr1:40754421    C/A rs767610978 chr1:40754421    C/T rs976303699 chr1:40754432    A/G rs367890071 chr1:40754418    A/G rs373732123 chr1:40754417    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFITM1	chr11:315267(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFITM1	chr11:313992-313993(+) m6A 5'UTR//intron       25456834//24981863 chr11:314008-314009(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314036-314037(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314088-314089(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314120-314121(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314134-314135(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314184-314185(+) m6A CDS       24284625//25456834//24981863 chr11:314260-314261(+) m6A CDS       - chr11:314928-314929(+) m6A CDS//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30e-3p	Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells     - Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	IFITM1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30e-3p
Interactor2: IFITM1

Evidence Support:

Strong-Evidence	RT-PCR
Support Database	ViRBase

References:

PMID	25122182	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	HeLa cells//U937 cells	Interactor2 expression	Upregulation
Description	We found that DENV infection could induce miR-30e* expression in DENV-permissive cells, and such an overexpression of miR-30e* upregulated IFN-beta and the downstream IFN-stimulated genes(ISGs) such as OAS1, MxA and IFITM1, and suppressed DENV replication.