Detail Information

Basic Information:


  VIRBase ID:  

HHID00019050

  Virus:  

Dengue virus (Dengue virus 2,DEN-2)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30e-3p:           IFNB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30e-3p IFNB1
miRBase
Accession/Entrez ID		 MIMAT0000693 3456
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - IFB//IFF//IFN-beta//IFNB

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30e-3p
rs1184629069 chr1:40754434    C/T
rs1217267713 chr1:40754424    A/C
rs1485494658 chr1:40754429    T/G
rs538913221 chr1:40754422    G/A
rs756374506 chr1:40754425    T/C
rs767610978 chr1:40754421    C/A
rs767610978 chr1:40754421    C/T
rs976303699 chr1:40754432    A/G
rs367890071 chr1:40754418    A/G
rs373732123 chr1:40754417    C/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IFNB1
chr9:21077198-21077199(-) m6A 3'UTR       27773535
chr9:21077273-21077274(-) m6A 3'UTR       27773535
chr9:21077278-21077279(-) m6A 3'UTR       27773535
chr9:21077308-21077309(-) m6A CDS       27773535
chr9:21077328-21077329(-) m6A CDS       27773535
chr9:21077347-21077348(-) m6A CDS       27773535
chr9:21077375-21077376(-) m6A CDS       27773535
chr9:21077592-21077593(-) m6A CDS       27773535
chr9:21077611-21077612(-) m6A CDS       27773535
chr9:21077695-21077696(-) m6A CDS       27773535
chr9:21077704-21077705(-) m6A CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30e-3p
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells     -
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30e-3p
Interactor2: IFNB1

Evidence Support:


Strong-Evidence ELISA//RT-PCR
Support Database ViRBase

References:


PMID 25122182 Target region None
Source ViRBase Interactor1 expression Upregulation
Tissue or cell line HeLa cells//U937 cells Interactor2 expression Downregulation
Description Our results showed that miR-30e* significantly induced mRNA and protein expression of IFN-beta in U937, HeLa and PBMC cells (Figure 4, A and B).

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