Basic Information:

  VIRBase ID:  

HHID00018921

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          ZDHHC21:  NM_001354129     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	ZDHHC21
miRBase Accession/Entrez ID	MIMAT0026482	340481
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DHHC-21//DHHC21//DNZ1//HSPC097

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZDHHC21	chr9:14689039(-) A-I      intronic chr9:14689845(-) A-I      intronic chr9:14689851(-) A-I      intronic chr9:14689036(-) A-I      intronic chr9:14681342(-) A-I      intronic chr9:14688548(-) A-I      intronic chr9:14689022(-) A-I      intronic chr9:14643040(-) A-I      intronic chr9:14689031(-) A-I      intronic chr9:14643133(-) A-I      intronic chr9:14689847(-) A-I      intronic chr9:14689002(-) A-I      intronic chr9:14689800(-) A-I      intronic chr9:14687665(-) A-I      intronic chr9:14689854(-) A-I      intronic chr9:14689043(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZDHHC21	chr9:14612633-14612634(-) m6A 3'UTR       24981863 chr9:14612690-14612691(-) m6A 3'UTR       24981863 chr9:14612702-14612703(-) m6A 3'UTR       24981863 chr9:14612710-14612711(-) m6A 3'UTR       24981863 chr9:14615863-14615864(-) m6A 3'UTR       27773535 chr9:14615883-14615884(-) m6A 3'UTR       27773535 chr9:14615953-14615954(-) m6A 3'UTR       27773535 chr9:14617029-14617030(-) m6A 3'UTR       24981863 chr9:14617040-14617041(-) m6A 3'UTR       24981863 chr9:14617125-14617126(-) m6A 3'UTR       24981863 chr9:14617298-14617299(-) m6A 3'UTR       27773535 chr9:14617312-14617313(-) m6A 3'UTR       27773535 chr9:14618326-14618327(-) m6A 3'UTR       27773535 chr9:14618429-14618430(-) m6A 3'UTR       27773535 chr9:14618894-14618895(-) m6A 3'UTR       24981863//22608085 chr9:14618962-14618963(-) m6A 3'UTR       24981863//22608085 chr9:14690374-14690375(-) m6A 5'UTR//exon       25456834//24981863//27371828//27773536 chr9:14693393-14693394(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	ZDHHC21	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: ZDHHC21

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).