Basic Information:

  VIRBase ID:  

HHID00018806

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          TMTC3:  NM_001366583     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	TMTC3
miRBase Accession/Entrez ID	MIMAT0026482	160418
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LIS8//SMILE

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMTC3	chr12:88557908(+) A-I      intronic chr12:88557899(+) A-I      intronic chr12:88556882(+) A-I      intronic chr12:88556709(+) A-I      intronic chr12:88556895(+) A-I      intronic chr12:88557711(+) A-I      intronic chr12:88556711(+) A-I      intronic chr12:88557812(+) A-I      intronic chr12:88557916(+) A-I      intronic chr12:88556779(+) A-I      intronic chr12:88556757(+) A-I      intronic chr12:88556749(+) A-I      intronic chr12:88557734(+) A-I      intronic chr12:88585561(+) A-I      intronic chr12:88557814(+) A-I      intronic chr12:88552842(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMTC3	chr12:88557814(+) A-G intron -    22484847 chr12:88556749(+) A-G intron -    22484847 chr12:88556757(+) A-G intron -    22484847 chr12:88556779(+) A-G intron -    22484847 chr12:88557734(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMTC3	chr12:88536086-88536087(+) m6A 5'UTR       25456834//24981863 chr12:88536116-88536117(+) m6A 5'UTR       25456834//24981863 chr12:88536155-88536156(+) m6A 5'UTR       25456834//24981863 chr12:88536177-88536178(+) m6A 5'UTR//intron       25456834//24981863 chr12:88586407-88586408(+) m6A CDS       24981863//26404942 chr12:88586451-88586452(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586500-88586501(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586509-88586510(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586529-88586530(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586548-88586549(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586566-88586567(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88588624-88588625(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88588630-88588631(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88588731-88588732(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr12:88588823-88588824(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:88588911-88588912(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:88589002-88589003(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:88589037-88589038(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589069-88589070(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589242-88589243(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589261-88589262(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589296-88589297(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589324-88589325(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589336-88589337(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589346-88589347(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589389-88589390(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589459-88589460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:88589577-88589578(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr12:88589765-88589766(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TMTC3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: TMTC3

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).