Basic Information:

  VIRBase ID:  

HHID00018738

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          VPS37A:  NM_152415     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	VPS37A
miRBase Accession/Entrez ID	MIMAT0026482	137492
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCRP1//PQBP2//SPG53

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VPS37A	chr8:17112825(+) A-I      intronic chr8:17112830(+) A-I      intronic chr8:17112831(+) A-I      intronic chr8:17120394(+) A-I      intronic chr8:17109737(+) A-I      intronic chr8:17109721(+) A-I      intronic chr8:17104982(+) A-I      intronic chr8:17124356(+) A-I      intronic chr8:17124361(+) A-I      intronic chr8:17124399(+) A-I      intronic chr8:17148584(+) A-I      intronic chr8:17148774(+) A-I      intronic chr8:17148783(+) A-I      intronic chr8:17109725(+) A-I      intronic chr8:17112806(+) A-I      intronic chr8:17121224(+) A-I      intronic chr8:17109730(+) A-I      intronic chr8:17148784(+) A-I      intronic chr8:17112780(+) A-I      intronic chr8:17109749(+) A-I      intronic chr8:17109746(+) A-I      intronic chr8:17155353(+) A-I      3'UTR chr8:17155389(+) A-I      3'UTR chr8:17153744(+) A-I      3'UTR chr8:17155364(+) A-I      3'UTR chr8:17155363(+) A-I      3'UTR chr8:17155354(+) A-I      3'UTR chr8:17155380(+) A-I      3'UTR chr8:17155405(+) A-I      3'UTR chr8:17155384(+) A-I      3'UTR chr8:17153808(+) A-I      3'UTR chr8:17155385(+) A-I      3'UTR chr8:17153751(+) A-I      3'UTR chr8:17155392(+) A-I      3'UTR chr8:17155361(+) A-I      3'UTR chr8:17155391(+) A-I      3'UTR chr8:17153809(+) A-I      3'UTR chr8:17109787(+) A-I      intronic chr8:17105913(+) A-I      intronic chr8:17124462(+) A-I      intronic chr8:17148587(+) A-I      intronic chr8:17109800(+) A-I      intronic chr8:17124519(+) A-I      intronic chr8:17120449(+) A-I      intronic chr8:17121439(+) A-I      intronic chr8:17124511(+) A-I      intronic chr8:17120316(+) A-I      intronic chr8:17121319(+) A-I      intronic chr8:17114314(+) A-I      intronic chr8:17124382(+) A-I      intronic chr8:17148597(+) A-I      intronic chr8:17124302(+) A-I      intronic chr8:17128860(+) A-I      intronic chr8:17112955(+) A-I      intronic chr8:17114262(+) A-I      intronic chr8:17112804(+) A-I      intronic chr8:17109705(+) A-I      intronic chr8:17112869(+) A-I      intronic chr8:17112922(+) A-I      intronic chr8:17112905(+) A-I      intronic chr8:17121357(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	VPS37A	chr8:17109705(+) A-G intron -    22484847 chr8:17109800(+) A-G intron -    22484847 chr8:17112804(+) A-G intron -    22484847 chr8:17112814(+) A-G intron -    22484847 chr8:17112869(+) A-G intron -    22484847 chr8:17112870(+) A-G intron -    22484847 chr8:17112905(+) A-G intron -    22484847 chr8:17112931(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VPS37A	chr8:17104229-17104230(+) m6A 5'UTR       24981863//27371828 chr8:17104293-17104294(+) m6A 5'UTR       24981863//27371828//27773536 chr8:17104523-17104524(+) m6A 5'UTR       24284625 chr8:17104588-17104589(+) m6A 5'UTR       - chr8:17104608-17104609(+) m6A 5'UTR       - chr8:17104681-17104682(+) m6A 5'UTR       25456834 chr8:17104742-17104743(+) m6A 5'UTR       - chr8:17132324-17132325(+) m6A CDS       24981863 chr8:17142063-17142064(+) m6A 3'UTR//CDS       27773535 chr8:17142122-17142123(+) m6A 3'UTR//CDS       27773535 chr8:17157367-17157368(+) m6A exon//intron       25456834//22608085 chr8:17157384-17157385(+) m6A exon//intron       25456834//22608085 chr8:17157453-17157454(+) m6A exon//intron       25456834//24981863//22608085 chr8:17157480-17157481(+) m6A exon//intron       25456834//24981863//22608085 chr8:17157517-17157518(+) m6A exon//intron       25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	VPS37A	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: VPS37A

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).