Detail Information

Basic Information:


  VIRBase ID:  

HHID00018733

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:           CLVS2:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-3p CLVS2
miRBase
Accession/Entrez ID		 MIMAT0026482 134829
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bA160A10.4//C6orf212//C6orf213//RLBP1L2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-3p
rs1367478528 chr15:62824008    C/T
rs146591219 chr15:62824027    C/T
rs1311298147 chr15:62824010    A/G
rs771043955 chr15:62824015    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CLVS2
chr6:123378762(+) A-I      intronic
chr6:123382270(+) A-I      intronic
chr6:123382303(+) A-I      intronic
chr6:123382214(+) A-I      intronic
chr6:123378578(+) A-I      intronic
chr6:123374495(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CLVS2
chr6:123318461-123318462(+) m6A 5'UTR//intron       22608085
chr6:123318470-123318471(+) m6A 5'UTR//intron       22608085
chr6:123318542-123318543(+) m6A 5'UTR//intron       22608085
chr6:123318560-123318561(+) m6A 5'UTR//intron       22608085
chr6:123318609-123318610(+) m6A 5'UTR//intron       22608085
chr6:123318777-123318778(+) m6A 5'UTR//intron       22608085
chr6:123318858-123318859(+) m6A 5'UTR//intron       25456834//22608085
chr6:123318875-123318876(+) m6A 5'UTR//intron       25456834//22608085
chr6:123318919-123318920(+) m6A 5'UTR//intron       25456834//22575960//22608085
chr6:123318955-123318956(+) m6A CDS//intron       25456834//22575960//22608085
chr6:123318989-123318990(+) m6A CDS//intron       25456834//22575960//22608085
chr6:123318995-123318996(+) m6A CDS//intron       25456834//22575960//22608085
chr6:123319010-123319011(+) m6A CDS//intron       25456834//22575960//22608085
chr6:123319049-123319050(+) m6A CDS//intron       25456834//22575960//22608085
chr6:123319166-123319167(+) m6A CDS//intron       25456834//22608085
chr6:123319172-123319173(+) m6A CDS//intron       25456834//22608085
chr6:123384877-123384878(+) m6A CDS       22608085
chr6:123384901-123384902(+) m6A CDS       22608085
chr6:123384967-123384968(+) m6A 3'UTR       22575960//22608085
chr6:123384997-123384998(+) m6A 3'UTR       22575960//22608085
chr6:123385060-123385061(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
CLVS2
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-3p
Interactor2: CLVS2

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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