Basic Information:

  VIRBase ID:  

HHID00018557

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          PLEKHF2:  NM_024613     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	PLEKHF2
miRBase Accession/Entrez ID	MIMAT0026482	79666
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EAPF//PHAFIN2//ZFYVE18

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLEKHF2	chr8:96157024(+) A-I      intronic chr8:96156821(+) A-I      intronic chr8:96157726(+) A-I      intronic chr8:96154717(+) A-I      intronic chr8:96157732(+) A-I      intronic chr8:96157120(+) A-I      intronic chr8:96157721(+) A-I      intronic chr8:96167873(+) A-I      3'UTR chr8:96157012(+) A-I      intronic chr8:96154718(+) A-I      intronic chr8:96156974(+) A-I      intronic chr8:96151667(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PLEKHF2	chr8:96156975(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLEKHF2	chr8:96146137-96146138(+) m6A 5'UTR       24981863 chr8:96146212-96146213(+) m6A 5'UTR       24209618//24981863//22608085 chr8:96146319-96146320(+) m6A 5'UTR//intron       22608085 chr8:96166291-96166292(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr8:96166330-96166331(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr8:96166499-96166500(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr8:96166555-96166556(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr8:96166581-96166582(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr8:96166689-96166690(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:96166703-96166704(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:96166915-96166916(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:96166945-96166946(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:96167024-96167025(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:96167137-96167138(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PLEKHF2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: PLEKHF2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).