Basic Information:

  VIRBase ID:  

HHID00018548

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          C2orf49:  NM_024093     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	C2orf49
miRBase Accession/Entrez ID	MIMAT0026482	79074
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	asw

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C2orf49	chr2:105962346(+) A-I      3'UTR chr2:105962332(+) A-I      3'UTR chr2:105962313(+) A-I      3'UTR chr2:105962341(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C2orf49	chr2:105956043-105956044(+) m6A CDS       27773535 chr2:105956057-105956058(+) m6A CDS       27773535 chr2:105956073-105956074(+) m6A CDS       27773535 chr2:105956079-105956080(+) m6A CDS       27773535 chr2:105956176-105956177(+) m6A CDS       24981863//27773535//22608085 chr2:105956198-105956199(+) m6A CDS       24981863//27773535//22608085 chr2:105959334-105959335(+) m6A CDS       24981863//27773535//22608085 chr2:105959389-105959390(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:105959519-105959520(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr2:105959532-105959533(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr2:105959553-105959554(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr2:105959558-105959559(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:105959626-105959627(+) m6A CDS       24284625//24209618//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	C2orf49	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: C2orf49

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).