Basic Information:

  VIRBase ID:  

HHID00018543

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          TMEM106C:  NM_024056     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	TMEM106C
miRBase Accession/Entrez ID	MIMAT0026482	79022
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMEM106C	chr12:48359487(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMEM106C	chr12:48357699-48357700(+) m6A 5'UTR//intron       24981863 chr12:48357929-48357930(+) m6A exon//intron       - chr12:48357992-48357993(+) m6A 5'UTR//exon//intron       - chr12:48358104-48358105(+) Gm 5'UTR//CDS//exon//intron       - chr12:48358116-48358117(+) m1A 5'UTR//CDS//exon//intron       26863196 chr12:48358187-48358188(+) m6A 5'UTR//CDS//exon//intron       - chr12:48362086-48362087(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942 chr12:48362142-48362143(+) m6A 3'UTR//exon       24284625//24981863//27773535 chr12:48362167-48362168(+) m6A 3'UTR//exon       24284625//24981863 chr12:48362201-48362202(+) m6A 3'UTR//exon       24284625//24981863 chr12:48362338-48362339(+) m6A 3'UTR       27773535 chr12:48362425-48362426(+) m6A 3'UTR       26404942//27773535 chr12:48362448-48362449(+) m6A 3'UTR       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TMEM106C	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: TMEM106C

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).