Detail Information

Basic Information:


  VIRBase ID:  

HHID00018516

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:           PERP:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-3p PERP
miRBase
Accession/Entrez ID		 MIMAT0026482 64065
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - dJ496H19.1//EKVP7//KCP1//KRTCAP1//OLMS2//PIGPC1//THW

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-3p
rs1367478528 chr15:62824008    C/T
rs146591219 chr15:62824027    C/T
rs1311298147 chr15:62824010    A/G
rs771043955 chr15:62824015    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PERP
chr6:138424485(-) A-I      intronic
chr6:138424424(-) A-I      intronic
chr6:138424493(-) A-I      intronic
chr6:138424462(-) A-I      intronic
chr6:138424492(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PERP
chr6:138411123-138411124(-) m6A 3'UTR       27773535
chr6:138412128-138412129(-) m6A 3'UTR       26404942
chr6:138412153-138412154(-) m6A 3'UTR       26404942
chr6:138412290-138412291(-) m6A 3'UTR       26404942
chr6:138412381-138412382(-) m6A 3'UTR       26404942
chr6:138412398-138412399(-) m6A 3'UTR       26404942
chr6:138412408-138412409(-) m6A 3'UTR       26404942
chr6:138412692-138412693(-) m6A 3'UTR       26404942
chr6:138412739-138412740(-) m6A 3'UTR       26404942//22608085
chr6:138413066-138413067(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr6:138413097-138413098(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr6:138413120-138413121(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr6:138413135-138413136(-) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr6:138413354-138413355(-) m6A CDS       24284625//26404942//27773535//22575960
chr6:138417542-138417543(-) m6A CDS       24284625//27773535//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PERP
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-3p
Interactor2: PERP

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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