Basic Information:

  VIRBase ID:  

HHID00018496

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          CYP4F11:  NM_001128932     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	CYP4F11
miRBase Accession/Entrez ID	MIMAT0026482	57834
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CYPIVF11

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CYP4F11	chr19:16024127-16024128(-) m6A 3'UTR       24981863 chr19:16024147-16024148(-) m6A 3'UTR       24981863 chr19:16024197-16024198(-) m6A 3'UTR       24981863 chr19:16024215-16024216(-) m6A 3'UTR       24981863 chr19:16024221-16024222(-) m6A 3'UTR       24981863 chr19:16024251-16024252(-) m6A 3'UTR       24981863 chr19:16024305-16024306(-) m6A 3'UTR       24981863 chr19:16024377-16024378(-) m6A 3'UTR       24981863 chr19:16024384-16024385(-) m6A 3'UTR       24981863 chr19:16024440-16024441(-) m6A 3'UTR       24981863 chr19:16024496-16024497(-) m6A 3'UTR       24981863 chr19:16024501-16024502(-) m6A 3'UTR       24981863 chr19:16024551-16024552(-) m6A 3'UTR//CDS       24981863 chr19:16024583-16024584(-) m6A 3'UTR//CDS       24981863 chr19:16024613-16024614(-) m6A 3'UTR//CDS       24981863 chr19:16024625-16024626(-) m6A 3'UTR//CDS       24981863 chr19:16045106-16045107(-) m6A CDS       - chr19:16045559-16045560(-) m6A 5'UTR//intron       24981863 chr19:16045631-16045632(-) m6A 5'UTR//intron       24981863 chr19:16045666-16045667(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CYP4F11	Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: CYP4F11

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).