Detail Information

Basic Information:


  VIRBase ID:  

HHID00018438

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:           PMEPA1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-3p PMEPA1
miRBase
Accession/Entrez ID		 MIMAT0026482 56937
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - STAG1//TMEPAI

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-3p
rs1367478528 chr15:62824008    C/T
rs146591219 chr15:62824027    C/T
rs1311298147 chr15:62824010    A/G
rs771043955 chr15:62824015    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PMEPA1
chr20:56240944(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PMEPA1
chr20:56223803-56223804(-) m6A 3'UTR       26404942
chr20:56223861-56223862(-) m6A 3'UTR       26404942
chr20:56224038-56224039(-) m6A 3'UTR       -
chr20:56226245-56226246(-) m6A 3'UTR       -
chr20:56227061-56227062(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22608085
chr20:56227120-56227121(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22608085
chr20:56227129-56227130(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22608085
chr20:56227197-56227198(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr20:56227404-56227405(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr20:56227409-56227410(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr20:56227436-56227437(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr20:56227441-56227442(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr20:56227460-56227461(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr20:56250930-56250931(-) Cm intron       -
chr20:56280082-56280083(-) Am intron       -
chr20:56284787-56284788(-) m6A 5'UTR//intron       24209618//27773536
chr20:56285526-56285527(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536
chr20:56285541-56285542(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828
chr20:56285552-56285553(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828
chr20:56286436-56286437(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr20:56286502-56286503(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr20:56286541-56286542(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863
chr20:56286560-56286561(-) m6A 5'UTR//exon       24209618//25456834//24981863
chr20:56286587-56286588(-) m6A 5'UTR//exon       24209618//25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
PMEPA1
Cytosol HeLa-S3 cells     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-3p
Interactor2: PMEPA1

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence DIANA-microT//miRDB//Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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