Basic Information:

  VIRBase ID:  

HHID00018379

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          PAK1IP1:  NM_017906     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	PAK1IP1
miRBase Accession/Entrez ID	MIMAT0026482	55003
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	bA421M1.5//hPIP1//MAK11//PIP1//WDR84

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAK1IP1	chr6:10701484(+) A-I      intronic chr6:10700525(+) A-I      intronic chr6:10701409(+) A-I      intronic chr6:10700392(+) A-I      intronic chr6:10701451(+) A-I      intronic chr6:10700409(+) A-I      intronic chr6:10701384(+) A-I      intronic chr6:10701427(+) A-I      intronic chr6:10698030(+) A-I      intronic chr6:10700526(+) A-I      intronic chr6:10704532(+) A-I      intronic chr6:10705286(+) A-I      intronic chr6:10698068(+) A-I      intronic chr6:10703120(+) A-I      intronic chr6:10702398(+) A-I      intronic chr6:10701532(+) A-I      intronic chr6:10705289(+) A-I      intronic chr6:10699326(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PAK1IP1	chr6:10705003(+) A-G exon CDS    21725310 chr6:10701350(+) A-G intron -    22484847 chr6:10703120(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAK1IP1	chr6:10697562-10697563(+) m6A CDS       24284625//24981863//22575960 chr6:10703685-10703686(+) m6A CDS       24981863 chr6:10704805-10704806(+) m6A CDS       24981863 chr6:10709216-10709217(+) m6A CDS       27773535 chr6:10709255-10709256(+) m6A CDS       24981863//27773535 chr6:10709267-10709268(+) m6A CDS       24981863//27773535 chr6:10709480-10709481(+) m6A CDS       24981863//27773535//22608085 chr6:10709543-10709544(+) m6A CDS       24209618//24981863//27773535//22608085 chr6:10709673-10709674(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr6:10709707-10709708(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr6:10709813-10709814(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	PAK1IP1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: PAK1IP1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).