Basic Information:

  VIRBase ID:  

HHID00018371

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          GDAP2:  NM_017686     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	GDAP2
miRBase Accession/Entrez ID	MIMAT0026482	54834
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MACROD3//SCAR27

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GDAP2	chr1:118410066(-) A-I      3'UTR chr1:118409393(-) A-I      3'UTR chr1:118410093(-) A-I      3'UTR chr1:118410094(-) A-I      3'UTR chr1:118410106(-) A-I      3'UTR chr1:118454482(-) A-I      intronic chr1:118442782(-) A-I      intronic chr1:118409363(-) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GDAP2	chr1:118411860-118411861(-) m6A 3'UTR       27773535 chr1:118411885-118411886(-) m6A 3'UTR       27773535 chr1:118412587-118412588(-) m6A 3'UTR       22608085 chr1:118412601-118412602(-) m6A 3'UTR       22608085 chr1:118412628-118412629(-) m6A 3'UTR       27773535//22608085 chr1:118412635-118412636(-) m6A 3'UTR       27773535//22608085 chr1:118412655-118412656(-) m6A 3'UTR       27773535//22608085 chr1:118412792-118412793(-) m6A 3'UTR       24981863//27773535 chr1:118412862-118412863(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr1:118412871-118412872(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr1:118412894-118412895(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr1:118413002-118413003(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr1:118419944-118419945(-) m6A 3'UTR//intron       27773535 chr1:118472189-118472190(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	GDAP2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: GDAP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).