Basic Information:

  VIRBase ID:  

HHID00018360

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          NDFIP2:  NM_001161407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	NDFIP2
miRBase Accession/Entrez ID	MIMAT0026482	54602
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	N4WBP5A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NDFIP2	chr13:80111372(+) A-I      intronic chr13:80111294(+) A-I      intronic chr13:80111382(+) A-I      intronic chr13:80104472(+) A-I      intronic chr13:80111274(+) A-I      intronic chr13:80102152(+) A-I      intronic chr13:80110975(+) A-I      intronic chr13:80112812(+) A-I      intronic chr13:80111446(+) A-I      intronic chr13:80111032(+) A-I      intronic chr13:80111301(+) A-I      intronic chr13:80111430(+) A-I      intronic chr13:80102141(+) A-I      intronic chr13:80102219(+) A-I      intronic chr13:80111042(+) A-I      intronic chr13:80113268(+) A-I      intronic chr13:80120131(+) A-I      intronic chr13:80058337(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NDFIP2	chr13:80055425-80055426(+) m6A CDS       24981863 chr13:80055495-80055496(+) m6A CDS       24981863 chr13:80055582-80055583(+) m6A CDS       24981863//22575960 chr13:80055641-80055642(+) m6A CDS       24981863//22575960 chr13:80093163-80093164(+) m6A exon//intron       - chr13:80126709-80126710(+) m6A 3'UTR       27773535 chr13:80126729-80126730(+) m6A 3'UTR       27773535 chr13:80128649-80128650(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NDFIP2	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: NDFIP2

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).