Basic Information:

  VIRBase ID:  

HHID00018308

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:  MIMAT0026482          DYNC1LI1:  NM_016141     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-190a-3p	DYNC1LI1
miRBase Accession/Entrez ID	MIMAT0026482	51143
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DLC-A//DNCLI1//LIC1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-190a-3p	rs1367478528 chr15:62824008    C/T rs146591219 chr15:62824027    C/T rs1311298147 chr15:62824010    A/G rs771043955 chr15:62824015    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DYNC1LI1	chr3:32604075(-) A-I      intronic chr3:32604922(-) A-I      intronic chr3:32604966(-) A-I      intronic chr3:32604988(-) A-I      intronic chr3:32605625(-) A-I      intronic chr3:32605753(-) A-I      intronic chr3:32607230(-) A-I      intronic chr3:32607295(-) A-I      intronic chr3:32607584(-) A-I      intronic chr3:32607750(-) A-I      intronic chr3:32608081(-) A-I      intronic chr3:32609372(-) A-I      intronic chr3:32609384(-) A-I      intronic chr3:32598252(-) A-I      intronic chr3:32598247(-) A-I      intronic chr3:32598238(-) A-I      intronic chr3:32598201(-) A-I      intronic chr3:32598198(-) A-I      intronic chr3:32598194(-) A-I      intronic chr3:32598190(-) A-I      intronic chr3:32594718(-) A-I      intronic chr3:32594715(-) A-I      intronic chr3:32594705(-) A-I      intronic chr3:32594695(-) A-I      intronic chr3:32594689(-) A-I      intronic chr3:32594687(-) A-I      intronic chr3:32594660(-) A-I      intronic chr3:32582130(-) A-I      intronic chr3:32582127(-) A-I      intronic chr3:32598203(-) A-I      intronic chr3:32574956(-) A-I      intronic chr3:32575441(-) A-I      intronic chr3:32575466(-) A-I      intronic chr3:32575474(-) A-I      intronic chr3:32575513(-) A-I      intronic chr3:32575649(-) A-I      intronic chr3:32575659(-) A-I      intronic chr3:32580162(-) A-I      intronic chr3:32582006(-) A-I      intronic chr3:32582009(-) A-I      intronic chr3:32582134(-) A-I      intronic chr3:32582137(-) A-I      intronic chr3:32585055(-) A-I      intronic chr3:32585063(-) A-I      intronic chr3:32585103(-) A-I      intronic chr3:32585171(-) A-I      intronic chr3:32585193(-) A-I      intronic chr3:32585298(-) A-I      intronic chr3:32585365(-) A-I      intronic chr3:32585374(-) A-I      intronic chr3:32585385(-) A-I      intronic chr3:32592401(-) A-I      intronic chr3:32594300(-) A-I      intronic chr3:32594309(-) A-I      intronic chr3:32594362(-) A-I      intronic chr3:32596429(-) A-I      intronic chr3:32598172(-) A-I      intronic chr3:32598213(-) A-I      intronic chr3:32598237(-) A-I      intronic chr3:32598895(-) A-I      intronic chr3:32598902(-) A-I      intronic chr3:32599665(-) A-I      intronic chr3:32599668(-) A-I      intronic chr3:32599719(-) A-I      intronic chr3:32600140(-) A-I      intronic chr3:32600172(-) A-I      intronic chr3:32600175(-) A-I      intronic chr3:32600299(-) A-I      intronic chr3:32600857(-) A-I      intronic chr3:32600865(-) A-I      intronic chr3:32600900(-) A-I      intronic chr3:32600911(-) A-I      intronic chr3:32600912(-) A-I      intronic chr3:32600935(-) A-I      intronic chr3:32600973(-) A-I      intronic chr3:32601004(-) A-I      intronic chr3:32601012(-) A-I      intronic chr3:32603747(-) A-I      intronic chr3:32575261(-) A-I      intronic chr3:32594605(-) A-I      intronic chr3:32603061(-) A-I      intronic chr3:32608147(-) A-I      intronic chr3:32585552(-) A-I      intronic chr3:32581640(-) A-I      intronic chr3:32583760(-) A-I      intronic chr3:32607327(-) A-I      intronic chr3:32583768(-) A-I      intronic chr3:32603585(-) A-I      intronic chr3:32603643(-) A-I      intronic chr3:32575160(-) A-I      intronic chr3:32603074(-) A-I      intronic chr3:32598205(-) A-I      intronic chr3:32596580(-) A-I      intronic chr3:32605576(-) A-I      intronic chr3:32585439(-) A-I      intronic chr3:32582061(-) A-I      intronic chr3:32605770(-) A-I      intronic chr3:32574857(-) A-I      intronic chr3:32603889(-) A-I      intronic chr3:32607199(-) A-I      intronic chr3:32598134(-) A-I      intronic chr3:32598070(-) A-I      intronic chr3:32575155(-) A-I      intronic chr3:32608118(-) A-I      intronic chr3:32585064(-) A-I      intronic chr3:32574868(-) A-I      intronic chr3:32602382(-) A-I      intronic chr3:32607136(-) A-I      intronic chr3:32603621(-) A-I      intronic chr3:32581557(-) A-I      intronic chr3:32602931(-) A-I      intronic chr3:32596526(-) A-I      intronic chr3:32603940(-) A-I      intronic chr3:32603929(-) A-I      intronic chr3:32607240(-) A-I      intronic chr3:32594371(-) A-I      intronic chr3:32609184(-) A-I      intronic chr3:32609169(-) A-I      intronic chr3:32585113(-) A-I      intronic chr3:32581532(-) A-I      intronic chr3:32573692(-) A-I      intronic chr3:32585313(-) A-I      intronic chr3:32600847(-) A-I      intronic chr3:32596565(-) A-I      intronic chr3:32603894(-) A-I      intronic chr3:32575564(-) A-I      intronic chr3:32585511(-) A-I      intronic chr3:32607656(-) A-I      intronic chr3:32607598(-) A-I      intronic chr3:32598836(-) A-I      intronic chr3:32573713(-) A-I      intronic chr3:32603510(-) A-I      intronic chr3:32607359(-) A-I      intronic chr3:32582126(-) A-I      intronic chr3:32607571(-) A-I      intronic chr3:32575451(-) A-I      intronic chr3:32586148(-) A-I      intronic chr3:32605737(-) A-I      intronic chr3:32598275(-) A-I      intronic chr3:32573895(-) A-I      intronic chr3:32585434(-) A-I      intronic chr3:32585312(-) A-I      intronic chr3:32609455(-) A-I      intronic chr3:32607620(-) A-I      intronic chr3:32581403(-) A-I      intronic chr3:32575411(-) A-I      intronic chr3:32600830(-) A-I      intronic chr3:32574935(-) A-I      intronic chr3:32575166(-) A-I      intronic chr3:32585514(-) A-I      intronic chr3:32605694(-) A-I      intronic chr3:32598253(-) A-I      intronic chr3:32603897(-) A-I      intronic chr3:32605613(-) A-I      intronic chr3:32604029(-) A-I      intronic chr3:32575186(-) A-I      intronic chr3:32585522(-) A-I      intronic chr3:32600958(-) A-I      intronic chr3:32605754(-) A-I      intronic chr3:32585170(-) A-I      intronic chr3:32600835(-) A-I      intronic chr3:32609416(-) A-I      intronic chr3:32600635(-) A-I      intronic chr3:32603714(-) A-I      intronic chr3:32604889(-) A-I      intronic chr3:32608148(-) A-I      intronic chr3:32585012(-) A-I      intronic chr3:32602346(-) A-I      intronic chr3:32608217(-) A-I      intronic chr3:32575477(-) A-I      intronic chr3:32583782(-) A-I      intronic chr3:32582045(-) A-I      intronic chr3:32599614(-) A-I      intronic chr3:32600909(-) A-I      intronic chr3:32579936(-) A-I      intronic chr3:32608065(-) A-I      intronic chr3:32575147(-) A-I      intronic chr3:32574930(-) A-I      intronic chr3:32575272(-) A-I      intronic chr3:32574912(-) A-I      intronic chr3:32575440(-) A-I      intronic chr3:32594265(-) A-I      intronic chr3:32574907(-) A-I      intronic chr3:32607198(-) A-I      intronic chr3:32585512(-) A-I      intronic chr3:32585391(-) A-I      intronic chr3:32605723(-) A-I      intronic chr3:32574847(-) A-I      intronic chr3:32600809(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DYNC1LI1	chr3:32574869(-) A-G intron -    22484847 chr3:32574930(-) A-G intron -    22484847 chr3:32575155(-) A-G intron -    22484847 chr3:32575160(-) A-G intron -    22484847 chr3:32581640(-) A-G intron -    22484847 chr3:32581989(-) A-G intron -    22484847 chr3:32582045(-) A-G intron -    22484847 chr3:32582061(-) A-G intron -    22484847 chr3:32585436(-) A-G intron -    22484847 chr3:32585511(-) A-G intron -    22484847 chr3:32585512(-) A-G intron -    22484847 chr3:32585514(-) A-G intron -    22484847 chr3:32585522(-) A-G intron -    22484847 chr3:32585552(-) A-G intron -    22484847 chr3:32594336(-) A-G intron -    22484847 chr3:32594371(-) A-G intron -    22484847 chr3:32596565(-) A-G intron -    22484847 chr3:32598836(-) A-G intron -    22484847 chr3:32599614(-) A-G intron -    22484847 chr3:32600809(-) A-G intron -    22484847 chr3:32600830(-) A-G intron -    22484847 chr3:32600847(-) A-G intron -    22484847 chr3:32600871(-) A-G intron -    22484847 chr3:32600914(-) A-G intron -    22484847 chr3:32603074(-) A-G intron -    22484847 chr3:32603714(-) A-G intron -    22484847 chr3:32604028(-) A-G intron -    22484847 chr3:32604029(-) A-G intron -    22484847 chr3:32605613(-) A-G intron -    22484847 chr3:32605694(-) A-G intron -    22484847 chr3:32605723(-) A-G intron -    22484847 chr3:32605770(-) A-G intron -    22484847 chr3:32607198(-) A-G intron -    22484847 chr3:32607199(-) A-G intron -    22484847 chr3:32607327(-) A-G intron -    22484847 chr3:32607359(-) A-G intron -    22484847 chr3:32607571(-) A-G intron -    22484847 chr3:32607572(-) A-G intron -    22484847 chr3:32607620(-) A-G intron -    22484847 chr3:32607656(-) A-G intron -    22484847 chr3:32608118(-) A-G intron -    22484847 chr3:32608130(-) A-G intron -    22484847 chr3:32608147(-) A-G intron -    22484847 chr3:32608148(-) A-G intron -    22484847 chr3:32609416(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DYNC1LI1	chr3:32567924-32567925(-) Y 3'UTR//exon       26075521 chr3:32568183-32568184(-) m6A 3'UTR//exon       24981863 chr3:32572589-32572590(-) m6A exon//intron       27773535 chr3:32572701-32572702(-) m6A exon//intron       27773535 chr3:32572795-32572796(-) m6A exon//intron       27773535 chr3:32572837-32572838(-) m6A exon//intron       27773535 chr3:32572917-32572918(-) m6A exon//intron       27773535 chr3:32572982-32572983(-) m6A exon//intron       27773535 chr3:32572994-32572995(-) m6A exon//intron       27773535 chr3:32582613-32582614(-) m6A CDS//exon       24981863 chr3:32582658-32582659(-) m6A CDS//exon       24981863 chr3:32582688-32582689(-) m6A CDS//exon       24981863 chr3:32586374-32586375(-) m6A CDS//exon//intron       24981863 chr3:32586383-32586384(-) m6A CDS//exon//intron       24981863 chr3:32587348-32587349(-) m6A CDS//exon//intron       24981863//27773535 chr3:32587436-32587437(-) m6A CDS//exon//intron       24981863//27773535 chr3:32612122-32612123(-) m6A CDS//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-190a-3p	Exosome Plasma     23663360 Exosome Plasma     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	DYNC1LI1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-190a-3p
Interactor2: DYNC1LI1

Evidence Support:

Weak-Evidence	RNA-Seq
Prediction-Evidence	DIANA-microT//miRDB//Targetscan
Support Database	ViRBase

References:

PMID	31570108	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	ARPE-19 human RPE cells	Interactor2 expression	None
Description	Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).