Detail Information

Basic Information:


  VIRBase ID:  

HHID00018296

  Virus:  

Zaire ebolavirus (ZEBOV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-190a-3p:           TPRKB:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-190a-3p TPRKB
miRBase
Accession/Entrez ID		 MIMAT0026482 51002
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CGI-121//CGI121//GAMOS5

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-190a-3p
rs1367478528 chr15:62824008    C/T
rs146591219 chr15:62824027    C/T
rs1311298147 chr15:62824010    A/G
rs771043955 chr15:62824015    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TPRKB
chr2:73959596(-) A-I      intronic
chr2:73961030(-) A-I      intronic
chr2:73961219(-) A-I      intronic
chr2:73960464(-) A-I      intronic
chr2:73959594(-) A-I      intronic
chr2:73961017(-) A-I      intronic
chr2:73959582(-) A-I      intronic
chr2:73959688(-) A-I      intronic
chr2:73959687(-) A-I      intronic
chr2:73961112(-) A-I      intronic
chr2:73960559(-) A-I      intronic
chr2:73961485(-) A-I      intronic
chr2:73961363(-) A-I      intronic
chr2:73959668(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TPRKB
chr2:73959714(-) A-I intron -    15258596
chr2:73959749(-) A-I intron -    15258596
chr2:73959753(-) A-I intron -    15258596
chr2:73959797(-) A-I intron -    15258596
chr2:73961485(-) A-I intron -    22327324
chr2:73959588(-) A-G intron -    22484847
chr2:73959670(-) A-G intron -    22484847
chr2:73959714(-) A-G intron -    22484847
chr2:73961485(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TPRKB
chr2:73958073-73958074(-) m6A exon//intron       27773535
chr2:73958174-73958175(-) m6A exon//intron       27773535//27371828
chr2:73958233-73958234(-) m6A exon//intron       27773535//27371828
chr2:73958248-73958249(-) m6A exon//intron       27773535//27371828
chr2:73959037-73959038(-) m6A exon//intron       27371828
chr2:73961613-73961614(-) m6A CDS//exon//intron       24981863//27773535
chr2:73961673-73961674(-) m6A CDS//exon//intron       24981863//27773535
chr2:73964524-73964525(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-190a-3p
Exosome Plasma     23663360
Exosome Plasma     24683445
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
TPRKB
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-190a-3p
Interactor2: TPRKB

Evidence Support:


Weak-Evidence RNA-Seq
Prediction-Evidence Targetscan
Support Database ViRBase

References:


PMID 31570108 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line ARPE-19 human RPE cells Interactor2 expression None
Description Table 1 List of miRNAs that were differentially expressed between EBOV- and mock-infected human RPE cells at 24 h post-infection.Putative target genes in EBOV-infected human RPE cells were predicted from the 15 highly differentially expressed miRNAs using algorithms: 2629 targets by Diana microT; 1799 targets by miRDB; and 14315 targets by TargetScan (Additional file 5).

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